Browse CDC7

Summary
SymbolCDC7
Namecell division cycle 7
Aliases huCdc7; HsCdc7; CDC7L1; CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1; CDC7 cell division cycl ......
Chromosomal Location1p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus.
Domain PF00069 Protein kinase domain
Function

Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.

> Gene Ontology
 
Biological Process GO:0000082 G1/S transition of mitotic cell cycle
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000724 double-strand break repair via homologous recombination
GO:0000725 recombinational repair
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0006270 DNA replication initiation
GO:0006275 regulation of DNA replication
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0006909 phagocytosis
GO:0007346 regulation of mitotic cell cycle
GO:0008360 regulation of cell shape
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0010571 positive regulation of nuclear cell cycle DNA replication
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0018105 peptidyl-serine phosphorylation
GO:0018209 peptidyl-serine modification
GO:0022604 regulation of cell morphogenesis
GO:0033260 nuclear DNA replication
GO:0033262 regulation of nuclear cell cycle DNA replication
GO:0044770 cell cycle phase transition
GO:0044772 mitotic cell cycle phase transition
GO:0044786 cell cycle DNA replication
GO:0044839 cell cycle G2/M phase transition
GO:0044843 cell cycle G1/S phase transition
GO:0045740 positive regulation of DNA replication
GO:0045787 positive regulation of cell cycle
GO:0045931 positive regulation of mitotic cell cycle
GO:0051052 regulation of DNA metabolic process
GO:0051054 positive regulation of DNA metabolic process
GO:0090068 positive regulation of cell cycle process
GO:0090329 regulation of DNA-dependent DNA replication
GO:1901987 regulation of cell cycle phase transition
GO:1901989 positive regulation of cell cycle phase transition
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1901992 positive regulation of mitotic cell cycle phase transition
GO:1902749 regulation of cell cycle G2/M phase transition
GO:1902751 positive regulation of cell cycle G2/M phase transition
GO:2000105 positive regulation of DNA-dependent DNA replication
Molecular Function GO:0004674 protein serine/threonine kinase activity
Cellular Component GO:0045171 intercellular bridge
> KEGG and Reactome Pathway
 
KEGG hsa04110 Cell cycle
Reactome R-HSA-176187: Activation of ATR in response to replication stress
R-HSA-68962: Activation of the pre-replicative complex
R-HSA-1640170: Cell Cycle
R-HSA-69620: Cell Cycle Checkpoints
R-HSA-69278: Cell Cycle, Mitotic
R-HSA-69306: DNA Replication
R-HSA-69002: DNA Replication Pre-Initiation
R-HSA-69206: G1/S Transition
R-HSA-69481: G2/M Checkpoints
R-HSA-68874: M/G1 Transition
R-HSA-453279: Mitotic G1-G1/S phases
Summary
SymbolCDC7
Namecell division cycle 7
Aliases huCdc7; HsCdc7; CDC7L1; CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1; CDC7 cell division cycl ......
Chromosomal Location1p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CDC7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolCDC7
Namecell division cycle 7
Aliases huCdc7; HsCdc7; CDC7L1; CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1; CDC7 cell division cycl ......
Chromosomal Location1p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CDC7 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.61 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 STARS Score: 5.29; FDR: 0.001 Resistant to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolCDC7
Namecell division cycle 7
Aliases huCdc7; HsCdc7; CDC7L1; CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1; CDC7 cell division cycl ......
Chromosomal Location1p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CDC7 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1450.572
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0850.947
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3160.725
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1010.81
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.3350.779
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.1940.895
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.2520.47
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.3030.817
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0580.964
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.240.715
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6650.464
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.3090.00478
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolCDC7
Namecell division cycle 7
Aliases huCdc7; HsCdc7; CDC7L1; CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1; CDC7 cell division cycl ......
Chromosomal Location1p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CDC7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCDC7
Namecell division cycle 7
Aliases huCdc7; HsCdc7; CDC7L1; CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1; CDC7 cell division cycl ......
Chromosomal Location1p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CDC7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CDC7.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCDC7
Namecell division cycle 7
Aliases huCdc7; HsCdc7; CDC7L1; CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1; CDC7 cell division cycl ......
Chromosomal Location1p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CDC7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCDC7
Namecell division cycle 7
Aliases huCdc7; HsCdc7; CDC7L1; CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1; CDC7 cell division cycl ......
Chromosomal Location1p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CDC7 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCDC7
Namecell division cycle 7
Aliases huCdc7; HsCdc7; CDC7L1; CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1; CDC7 cell division cycl ......
Chromosomal Location1p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CDC7 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCDC7
Namecell division cycle 7
Aliases huCdc7; HsCdc7; CDC7L1; CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1; CDC7 cell division cycl ......
Chromosomal Location1p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CDC7 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.