TISIDB

Summary
Symbol	CDH17
Name	cadherin 17, LI cadherin (liver-intestine)
Aliases	HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ......
Chromosomal Location	8q22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cell membrane Single-pass type I membrane protein
Domain	PF00028 Cadherin domain
Function	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.

> Gene Ontology [ TOP ]
Biological Process	GO:0002263 cell activation involved in immune response GO:0002285 lymphocyte activation involved in immune response GO:0002312 B cell activation involved in immune response GO:0002313 mature B cell differentiation involved in immune response GO:0002314 germinal center B cell differentiation GO:0002315 marginal zone B cell differentiation GO:0002335 mature B cell differentiation GO:0002366 leukocyte activation involved in immune response GO:0002521 leukocyte differentiation GO:0006857 oligopeptide transport GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007229 integrin-mediated signaling pathway GO:0015833 peptide transport GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0030098 lymphocyte differentiation GO:0030183 B cell differentiation GO:0031334 positive regulation of protein complex assembly GO:0033622 integrin activation GO:0033623 regulation of integrin activation GO:0033625 positive regulation of integrin activation GO:0033626 positive regulation of integrin activation by cell surface receptor linked signal transduction GO:0034330 cell junction organization GO:0034332 adherens junction organization GO:0035672 oligopeptide transmembrane transport GO:0042113 B cell activation GO:0042886 amide transport GO:0043254 regulation of protein complex assembly GO:0044089 positive regulation of cellular component biogenesis GO:0045216 cell-cell junction organization GO:0048536 spleen development GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules
Molecular Function	GO:0005178 integrin binding GO:0005427 proton-dependent oligopeptide secondary active transmembrane transporter activity GO:0015197 peptide transporter activity GO:0015198 oligopeptide transporter activity GO:0015291 secondary active transmembrane transporter activity GO:0015322 secondary active oligopeptide transmembrane transporter activity GO:0022804 active transmembrane transporter activity GO:0035673 oligopeptide transmembrane transporter activity GO:0042887 amide transmembrane transporter activity GO:0050839 cell adhesion molecule binding GO:1904680 peptide transmembrane transporter activity
Cellular Component	GO:0016323 basolateral plasma membrane

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-418990: Adherens junctions interactions R-HSA-446728: Cell junction organization R-HSA-1500931: Cell-Cell communication R-HSA-421270: Cell-cell junction organization

Summary
Symbol	CDH17
Name	cadherin 17, LI cadherin (liver-intestine)
Aliases	HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ......
Chromosomal Location	8q22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between CDH17 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	CDH17
Name	cadherin 17, LI cadherin (liver-intestine)
Aliases	HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ......
Chromosomal Location	8q22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of CDH17 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	CDH17
Name	cadherin 17, LI cadherin (liver-intestine)
Aliases	HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ......
Chromosomal Location	8q22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of CDH17 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0	1
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0	1
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0	1
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.94	0.0625
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.72	0.539
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-1.216	0.397
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.11	0.872
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.379	0.744
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.439	0.761
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.313	0.585
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.27	0.708
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.825	0.0109

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of CDH17 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	11.1	2.7	8.4	0.12
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	11.1	3.4	7.7	0.176
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	17.6	-12.8	0.307
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	12.5	16.7	-4.2	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	18.2	-18.2	0.199
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	0	11.1	0.36
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	25	0	25	0.364
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	5.3	0	5.3	0.507
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	0	4.5	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	6.2	0	6.2	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	CDH17
Name	cadherin 17, LI cadherin (liver-intestine)
Aliases	HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ......
Chromosomal Location	8q22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CDH17. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	CDH17
Name	cadherin 17, LI cadherin (liver-intestine)
Aliases	HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ......
Chromosomal Location	8q22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CDH17. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CDH17. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	CDH17
Name	cadherin 17, LI cadherin (liver-intestine)
Aliases	HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ......
Chromosomal Location	8q22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CDH17. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	CDH17
Name	cadherin 17, LI cadherin (liver-intestine)
Aliases	HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ......
Chromosomal Location	8q22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of CDH17 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	CDH17
Name	cadherin 17, LI cadherin (liver-intestine)
Aliases	HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ......
Chromosomal Location	8q22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between CDH17 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	CDH17
Name	cadherin 17, LI cadherin (liver-intestine)
Aliases	HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ......
Chromosomal Location	8q22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting CDH17 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse CDH17