| Summary | |
|---|---|
| Symbol | CDK3 |
| Name | cyclin-dependent kinase 3 |
| Aliases | cell division protein kinase 3 |
| Chromosomal Location | 17q25.1 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
| Subcellular Location | - |
| Domain |
PF00069 Protein kinase domain |
| Function |
Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner. |
| Biological Process |
GO:0000082 G1/S transition of mitotic cell cycle GO:0007067 mitotic nuclear division GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044843 cell cycle G1/S phase transition GO:0045023 G0 to G1 transition |
| Molecular Function |
GO:0004674 protein serine/threonine kinase activity GO:0004693 cyclin-dependent protein serine/threonine kinase activity GO:0097472 cyclin-dependent protein kinase activity |
| Cellular Component | - |
| KEGG | - |
| Reactome | - |
| Summary | |
|---|---|
| Symbol | CDK3 |
| Name | cyclin-dependent kinase 3 |
| Aliases | cell division protein kinase 3 |
| Chromosomal Location | 17q25.1 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content | Literatures that report relations between CDK3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
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There is no record. |
| Summary | |
|---|---|
| Symbol | CDK3 |
| Name | cyclin-dependent kinase 3 |
| Aliases | cell division protein kinase 3 |
| Chromosomal Location | 17q25.1 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
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> High-throughput Screening
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Statistical results of CDK3 in screening data sets for detecting immune reponses.
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| Summary | |
|---|---|
| Symbol | CDK3 |
| Name | cyclin-dependent kinase 3 |
| Aliases | cell division protein kinase 3 |
| Chromosomal Location | 17q25.1 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
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Points in the above scatter plot represent the expression difference of CDK3 in various data sets.
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There is no record. |
| Summary | |
|---|---|
| Symbol | CDK3 |
| Name | cyclin-dependent kinase 3 |
| Aliases | cell division protein kinase 3 |
| Chromosomal Location | 17q25.1 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CDK3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
| Summary | |
|---|---|
| Symbol | CDK3 |
| Name | cyclin-dependent kinase 3 |
| Aliases | cell division protein kinase 3 |
| Chromosomal Location | 17q25.1 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CDK3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CDK3. > Immunoinhibitor > Immunostimulator > MHC molecule |
| Summary | |
|---|---|
| Symbol | CDK3 |
| Name | cyclin-dependent kinase 3 |
| Aliases | cell division protein kinase 3 |
| Chromosomal Location | 17q25.1 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CDK3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
| Summary | |
|---|---|
| Symbol | CDK3 |
| Name | cyclin-dependent kinase 3 |
| Aliases | cell division protein kinase 3 |
| Chromosomal Location | 17q25.1 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Distribution of CDK3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
| Summary | |
|---|---|
| Symbol | CDK3 |
| Name | cyclin-dependent kinase 3 |
| Aliases | cell division protein kinase 3 |
| Chromosomal Location | 17q25.1 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Associations between CDK3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |