Browse CDK5R1

Summary
SymbolCDK5R1
Namecyclin-dependent kinase 5, regulatory subunit 1 (p35)
Aliases p35nck5a; Nck5a; CDK5P35; CDK5R; CDK5 activator 1; TPKII regulatory subunit; cyclin-dependent kinase 5 regul ......
Chromosomal Location17q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cyclin-dependent kinase 5 activator 1, p35: Cell membrane Lipid-anchor Cytoplasmic side Note=In the primary cortical neurons, p35 is present in the peripheries and nerve terminals.; SUBCELLULAR LOCATION: Cyclin-dependent kinase 5 activator 1, p25: Nucleus. Cytoplasm, perinuclear region. Note=The conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, in nuclear and perinuclear regions. In the primary cortical neurons, p25 is primarily concentrated in the cell soma and is largely absent from neurites.
Domain PF03261 Cyclin-dependent kinase 5 activator protein
Function

p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.

> Gene Ontology
 
Biological Process GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000226 microtubule cytoskeleton organization
GO:0001558 regulation of cell growth
GO:0001764 neuron migration
GO:0006612 protein targeting to membrane
GO:0006914 autophagy
GO:0007050 cell cycle arrest
GO:0007158 neuron cell-cell adhesion
GO:0007213 G-protein coupled acetylcholine receptor signaling pathway
GO:0007215 glutamate receptor signaling pathway
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007413 axonal fasciculation
GO:0008037 cell recognition
GO:0008038 neuron recognition
GO:0008347 glial cell migration
GO:0008361 regulation of cell size
GO:0010506 regulation of autophagy
GO:0010721 negative regulation of cell development
GO:0010769 regulation of cell morphogenesis involved in differentiation
GO:0010771 negative regulation of cell morphogenesis involved in differentiation
GO:0010975 regulation of neuron projection development
GO:0010977 negative regulation of neuron projection development
GO:0016049 cell growth
GO:0016236 macroautophagy
GO:0016241 regulation of macroautophagy
GO:0016358 dendrite development
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0018209 peptidyl-serine modification
GO:0018210 peptidyl-threonine modification
GO:0021537 telencephalon development
GO:0021543 pallium development
GO:0021548 pons development
GO:0021549 cerebellum development
GO:0021578 hindbrain maturation
GO:0021586 pons maturation
GO:0021626 central nervous system maturation
GO:0021700 developmental maturation
GO:0021718 superior olivary nucleus development
GO:0021722 superior olivary nucleus maturation
GO:0021761 limbic system development
GO:0021766 hippocampus development
GO:0021795 cerebral cortex cell migration
GO:0021799 cerebral cortex radially oriented cell migration
GO:0021801 cerebral cortex radial glia guided migration
GO:0021819 layer formation in cerebral cortex
GO:0021885 forebrain cell migration
GO:0021987 cerebral cortex development
GO:0022029 telencephalon cell migration
GO:0022030 telencephalon glial cell migration
GO:0022037 metencephalon development
GO:0022604 regulation of cell morphogenesis
GO:0030308 negative regulation of cell growth
GO:0030516 regulation of axon extension
GO:0030517 negative regulation of axon extension
GO:0030900 forebrain development
GO:0030902 hindbrain development
GO:0031345 negative regulation of cell projection organization
GO:0032386 regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0032535 regulation of cellular component size
GO:0032886 regulation of microtubule-based process
GO:0032956 regulation of actin cytoskeleton organization
GO:0032970 regulation of actin filament-based process
GO:0033136 serine phosphorylation of STAT3 protein
GO:0033157 regulation of intracellular protein transport
GO:0033674 positive regulation of kinase activity
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0042063 gliogenesis
GO:0042501 serine phosphorylation of STAT protein
GO:0043523 regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0045665 negative regulation of neuron differentiation
GO:0045786 negative regulation of cell cycle
GO:0045787 positive regulation of cell cycle
GO:0045860 positive regulation of protein kinase activity
GO:0045926 negative regulation of growth
GO:0046425 regulation of JAK-STAT cascade
GO:0048013 ephrin receptor signaling pathway
GO:0048511 rhythmic process
GO:0048588 developmental cell growth
GO:0048638 regulation of developmental growth
GO:0048640 negative regulation of developmental growth
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048675 axon extension
GO:0048813 dendrite morphogenesis
GO:0048814 regulation of dendrite morphogenesis
GO:0048857 neural nucleus development
GO:0050768 negative regulation of neurogenesis
GO:0050770 regulation of axonogenesis
GO:0050771 negative regulation of axonogenesis
GO:0050773 regulation of dendrite development
GO:0051222 positive regulation of protein transport
GO:0051402 neuron apoptotic process
GO:0051493 regulation of cytoskeleton organization
GO:0051961 negative regulation of nervous system development
GO:0060359 response to ammonium ion
GO:0060560 developmental growth involved in morphogenesis
GO:0060996 dendritic spine development
GO:0060997 dendritic spine morphogenesis
GO:0060998 regulation of dendritic spine development
GO:0061001 regulation of dendritic spine morphogenesis
GO:0061387 regulation of extent of cell growth
GO:0061564 axon development
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0070997 neuron death
GO:0071156 regulation of cell cycle arrest
GO:0071158 positive regulation of cell cycle arrest
GO:0071242 cellular response to ammonium ion
GO:0071695 anatomical structure maturation
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0072331 signal transduction by p53 class mediator
GO:0072657 protein localization to membrane
GO:0090066 regulation of anatomical structure size
GO:0090068 positive regulation of cell cycle process
GO:0090150 establishment of protein localization to membrane
GO:0090313 regulation of protein targeting to membrane
GO:0090314 positive regulation of protein targeting to membrane
GO:0090316 positive regulation of intracellular protein transport
GO:0095500 acetylcholine receptor signaling pathway
GO:0097061 dendritic spine organization
GO:0097485 neuron projection guidance
GO:1901214 regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1903533 regulation of protein targeting
GO:1903829 positive regulation of cellular protein localization
GO:1903831 signal transduction involved in cellular response to ammonium ion
GO:1904029 regulation of cyclin-dependent protein kinase activity
GO:1904892 regulation of STAT cascade
GO:1904951 positive regulation of establishment of protein localization
GO:1905144 response to acetylcholine
GO:1905145 cellular response to acetylcholine
GO:1990138 neuron projection extension
Molecular Function GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0008047 enzyme activator activity
GO:0016534 cyclin-dependent protein kinase 5 activator activity
GO:0019207 kinase regulator activity
GO:0019209 kinase activator activity
GO:0019887 protein kinase regulator activity
GO:0030295 protein kinase activator activity
GO:0043539 protein serine/threonine kinase activator activity
GO:0045296 cadherin binding
GO:0046875 ephrin receptor binding
GO:0050839 cell adhesion molecule binding
GO:0097472 cyclin-dependent protein kinase activity
Cellular Component GO:0014069 postsynaptic density
GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0030427 site of polarized growth
GO:0031594 neuromuscular junction
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0043292 contractile fiber
GO:0044297 cell body
GO:0044309 neuron spine
GO:0060076 excitatory synapse
GO:0098794 postsynapse
GO:0099572 postsynaptic specialization
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-422475: Axon guidance
R-HSA-399956: CRMPs in Sema3A signaling
R-HSA-8862803: Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
R-HSA-1266738: Developmental Biology
R-HSA-1643685: Disease
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-8863678: Neurodegenerative Diseases
R-HSA-5633007: Regulation of TP53 Activity
R-HSA-6804756: Regulation of TP53 Activity through Phosphorylation
R-HSA-373755: Semaphorin interactions
R-HSA-3700989: Transcriptional Regulation by TP53
Summary
SymbolCDK5R1
Namecyclin-dependent kinase 5, regulatory subunit 1 (p35)
Aliases p35nck5a; Nck5a; CDK5P35; CDK5R; CDK5 activator 1; TPKII regulatory subunit; cyclin-dependent kinase 5 regul ......
Chromosomal Location17q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CDK5R1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolCDK5R1
Namecyclin-dependent kinase 5, regulatory subunit 1 (p35)
Aliases p35nck5a; Nck5a; CDK5P35; CDK5R; CDK5 activator 1; TPKII regulatory subunit; cyclin-dependent kinase 5 regul ......
Chromosomal Location17q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CDK5R1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCDK5R1
Namecyclin-dependent kinase 5, regulatory subunit 1 (p35)
Aliases p35nck5a; Nck5a; CDK5P35; CDK5R; CDK5 activator 1; TPKII regulatory subunit; cyclin-dependent kinase 5 regul ......
Chromosomal Location17q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CDK5R1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.7980.0377
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)651.2610.464
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.4610.719
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1650.691
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.5270.635
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2950.834
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.130.765
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0050.998
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.20.901
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.4350.484
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.7610.361
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.030.836
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CDK5R1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCDK5R1
Namecyclin-dependent kinase 5, regulatory subunit 1 (p35)
Aliases p35nck5a; Nck5a; CDK5P35; CDK5R; CDK5 activator 1; TPKII regulatory subunit; cyclin-dependent kinase 5 regul ......
Chromosomal Location17q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CDK5R1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCDK5R1
Namecyclin-dependent kinase 5, regulatory subunit 1 (p35)
Aliases p35nck5a; Nck5a; CDK5P35; CDK5R; CDK5 activator 1; TPKII regulatory subunit; cyclin-dependent kinase 5 regul ......
Chromosomal Location17q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CDK5R1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CDK5R1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCDK5R1
Namecyclin-dependent kinase 5, regulatory subunit 1 (p35)
Aliases p35nck5a; Nck5a; CDK5P35; CDK5R; CDK5 activator 1; TPKII regulatory subunit; cyclin-dependent kinase 5 regul ......
Chromosomal Location17q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CDK5R1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCDK5R1
Namecyclin-dependent kinase 5, regulatory subunit 1 (p35)
Aliases p35nck5a; Nck5a; CDK5P35; CDK5R; CDK5 activator 1; TPKII regulatory subunit; cyclin-dependent kinase 5 regul ......
Chromosomal Location17q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CDK5R1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCDK5R1
Namecyclin-dependent kinase 5, regulatory subunit 1 (p35)
Aliases p35nck5a; Nck5a; CDK5P35; CDK5R; CDK5 activator 1; TPKII regulatory subunit; cyclin-dependent kinase 5 regul ......
Chromosomal Location17q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CDK5R1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCDK5R1
Namecyclin-dependent kinase 5, regulatory subunit 1 (p35)
Aliases p35nck5a; Nck5a; CDK5P35; CDK5R; CDK5 activator 1; TPKII regulatory subunit; cyclin-dependent kinase 5 regul ......
Chromosomal Location17q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CDK5R1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting CDK5R1.
ID Name Drug Type Targets #Targets
DB02052Indirubin-3'-MonoximeSmall MoleculeAHR, CDK1, CDK2, CDK5, CDK5R1, GSK3B6
DB073646-PHENYL[5H]PYRROLO[2,3-B]PYRAZINESmall MoleculeCDK5, CDK5R12