TISIDB

Summary
Symbol	CGA
Name	glycoprotein hormones, alpha polypeptide
Aliases	GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ......
Chromosomal Location	6q14.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Secreted.
Domain	PF00236 Glycoprotein hormone
Function	-

> Gene Ontology [ TOP ]
Biological Process	GO:0010817 regulation of hormone levels GO:0016485 protein processing GO:0016486 peptide hormone processing GO:0030335 positive regulation of cell migration GO:0040017 positive regulation of locomotion GO:0042445 hormone metabolic process GO:0051272 positive regulation of cellular component movement GO:0051604 protein maturation GO:2000147 positive regulation of cell motility
Molecular Function	GO:0005179 hormone activity
Cellular Component	GO:0005796 Golgi lumen

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04080 Neuroactive ligand-receptor interaction hsa04912 GnRH signaling pathway hsa04913 Ovarian steroidogenesis hsa04917 Prolactin signaling pathway hsa04918 Thyroid hormone synthesis
Reactome	R-HSA-209776: Amine-derived hormones R-HSA-193048: Androgen biosynthesis R-HSA-446203: Asparagine N-linked glycosylation R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-418555: G alpha (s) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-209822: Glycoprotein hormones R-HSA-375281: Hormone ligand-binding receptors R-HSA-1430728: Metabolism R-HSA-71291: Metabolism of amino acids and derivatives R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-392499: Metabolism of proteins R-HSA-196071: Metabolism of steroid hormones R-HSA-193993: Mineralocorticoid biosynthesis R-HSA-975576: N-glycan antennae elongation in the medial/trans-Golgi R-HSA-209952: Peptide hormone biosynthesis R-HSA-2980736: Peptide hormone metabolism R-HSA-597592: Post-translational protein modification R-HSA-975578: Reactions specific to the complex N-glycan synthesis pathway R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR R-HSA-209943: Steroid hormones R-HSA-8866910: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-209968: Thyroxine biosynthesis R-HSA-8864260: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-948021: Transport to the Golgi and subsequent modification

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04080 Neuroactive ligand-receptor interaction
hsa04912 GnRH signaling pathway
hsa04913 Ovarian steroidogenesis
hsa04917 Prolactin signaling pathway
hsa04918 Thyroid hormone synthesis

Reactome

R-HSA-209776: Amine-derived hormones
R-HSA-193048: Androgen biosynthesis
R-HSA-446203: Asparagine N-linked glycosylation
R-HSA-373076: Class A/1 (Rhodopsin-like receptors)
R-HSA-418555: G alpha (s) signalling events
R-HSA-388396: GPCR downstream signaling
R-HSA-500792: GPCR ligand binding
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-209822: Glycoprotein hormones
R-HSA-375281: Hormone ligand-binding receptors
R-HSA-1430728: Metabolism
R-HSA-71291: Metabolism of amino acids and derivatives
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-392499: Metabolism of proteins
R-HSA-196071: Metabolism of steroid hormones
R-HSA-193993: Mineralocorticoid biosynthesis
R-HSA-975576: N-glycan antennae elongation in the medial/trans-Golgi
R-HSA-209952: Peptide hormone biosynthesis
R-HSA-2980736: Peptide hormone metabolism
R-HSA-597592: Post-translational protein modification
R-HSA-975578: Reactions specific to the complex N-glycan synthesis pathway
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
R-HSA-209943: Steroid hormones
R-HSA-8866910: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
R-HSA-209968: Thyroxine biosynthesis
R-HSA-8864260: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
R-HSA-948021: Transport to the Golgi and subsequent modification

Summary
Symbol	CGA
Name	glycoprotein hormones, alpha polypeptide
Aliases	GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ......
Chromosomal Location	6q14.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between CGA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

[ TOP ]

Literatures describing the relation between CGA and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
27435394	Ovarian Carcinoma	Promote immunity	FSHR is expressed in gynecologic malignancies of different histologic types but not in nonovarian healthy tissues. T cells redirected against FSHR+ tumor cells with full-length FSH represent a promising therapeutic alternative against a broad range of ovarian malignancies, with negligible toxicity even in the presence of cognate targets in tumor-free ovaries.

Summary
Symbol	CGA
Name	glycoprotein hormones, alpha polypeptide
Aliases	GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ......
Chromosomal Location	6q14.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of CGA in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	CGA
Name	glycoprotein hormones, alpha polypeptide
Aliases	GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ......
Chromosomal Location	6q14.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of CGA in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0	1
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0	1
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0	1
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-1.509	0.124
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-1.901	0.184
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-1.036	0.604
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0	1
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0	1
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0	1
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0	1
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0	1
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.055	0.864

> Mutation difference between responders and non-responders [ TOP ]
There is no record.

Summary
Symbol	CGA
Name	glycoprotein hormones, alpha polypeptide
Aliases	GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ......
Chromosomal Location	6q14.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CGA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	CGA
Name	glycoprotein hormones, alpha polypeptide
Aliases	GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ......
Chromosomal Location	6q14.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CGA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CGA. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	CGA
Name	glycoprotein hormones, alpha polypeptide
Aliases	GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ......
Chromosomal Location	6q14.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CGA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	CGA
Name	glycoprotein hormones, alpha polypeptide
Aliases	GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ......
Chromosomal Location	6q14.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of CGA expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	CGA
Name	glycoprotein hormones, alpha polypeptide
Aliases	GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ......
Chromosomal Location	6q14.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between CGA and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	CGA
Name	glycoprotein hormones, alpha polypeptide
Aliases	GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ......
Chromosomal Location	6q14.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting CGA collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse CGA