Browse CHMP4A

Summary
SymbolCHMP4A
Namecharged multivesicular body protein 4A
Aliases HSPC134; VPS32A; C14orf123; chromosome 14 open reading frame 123; chromatin modifying protein 4A; CHMP4; SHA ......
Chromosomal Location14q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasmic vesicle membrane. Late endosome membrane Peripheral membrane protein Note=Membrane-associated. Localizes to large vesicle-like structures. Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.
Domain PF03357 Snf7
Function

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).

> Gene Ontology
 
Biological Process GO:0000045 autophagosome assembly
GO:0000070 mitotic sister chromatid segregation
GO:0000819 sister chromatid segregation
GO:0000920 cell separation after cytokinesis
GO:0006612 protein targeting to membrane
GO:0006620 posttranslational protein targeting to membrane
GO:0006900 membrane budding
GO:0006914 autophagy
GO:0006997 nucleus organization
GO:0007009 plasma membrane organization
GO:0007032 endosome organization
GO:0007033 vacuole organization
GO:0007034 vacuolar transport
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0007080 mitotic metaphase plate congression
GO:0010324 membrane invagination
GO:0010506 regulation of autophagy
GO:0010507 negative regulation of autophagy
GO:0010639 negative regulation of organelle organization
GO:0016050 vesicle organization
GO:0016197 endosomal transport
GO:0016236 macroautophagy
GO:0016241 regulation of macroautophagy
GO:0016242 negative regulation of macroautophagy
GO:0019058 viral life cycle
GO:0019068 virion assembly
GO:0036257 multivesicular body organization
GO:0036258 multivesicular body assembly
GO:0039702 viral budding via host ESCRT complex
GO:0044088 regulation of vacuole organization
GO:0044803 multi-organism membrane organization
GO:0045047 protein targeting to ER
GO:0046755 viral budding
GO:0050000 chromosome localization
GO:0051258 protein polymerization
GO:0051259 protein oligomerization
GO:0051260 protein homooligomerization
GO:0051303 establishment of chromosome localization
GO:0051310 metaphase plate congression
GO:0051640 organelle localization
GO:0051656 establishment of organelle localization
GO:0070972 protein localization to endoplasmic reticulum
GO:0070997 neuron death
GO:0072599 establishment of protein localization to endoplasmic reticulum
GO:0072657 protein localization to membrane
GO:0090150 establishment of protein localization to membrane
GO:0097320 membrane tubulation
GO:0098813 nuclear chromosome segregation
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1902115 regulation of organelle assembly
GO:1902116 negative regulation of organelle assembly
GO:1902590 multi-organism organelle organization
GO:1902592 multi-organism membrane budding
GO:1902902 negative regulation of autophagosome assembly
GO:1905037 autophagosome organization
GO:2000785 regulation of autophagosome assembly
Molecular Function GO:0051117 ATPase binding
Cellular Component GO:0000815 ESCRT III complex
GO:0005770 late endosome
GO:0009898 cytoplasmic side of plasma membrane
GO:0010008 endosome membrane
GO:0030117 membrane coat
GO:0030496 midbody
GO:0030659 cytoplasmic vesicle membrane
GO:0031902 late endosome membrane
GO:0036452 ESCRT complex
GO:0044440 endosomal part
GO:0048475 coated membrane
GO:0098552 side of membrane
GO:0098562 cytoplasmic side of membrane
> KEGG and Reactome Pathway
 
KEGG hsa04144 Endocytosis
Reactome R-HSA-162588: Budding and maturation of HIV virion
R-HSA-2262752: Cellular responses to stress
R-HSA-1643685: Disease
R-HSA-917729: Endosomal Sorting Complex Required For Transport (ESCRT)
R-HSA-162906: HIV Infection
R-HSA-162587: HIV Life Cycle
R-HSA-5663205: Infectious disease
R-HSA-162599: Late Phase of HIV Life Cycle
R-HSA-1632852: Macroautophagy
R-HSA-199991: Membrane Trafficking
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolCHMP4A
Namecharged multivesicular body protein 4A
Aliases HSPC134; VPS32A; C14orf123; chromosome 14 open reading frame 123; chromatin modifying protein 4A; CHMP4; SHA ......
Chromosomal Location14q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CHMP4A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolCHMP4A
Namecharged multivesicular body protein 4A
Aliases HSPC134; VPS32A; C14orf123; chromosome 14 open reading frame 123; chromatin modifying protein 4A; CHMP4; SHA ......
Chromosomal Location14q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CHMP4A in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCHMP4A
Namecharged multivesicular body protein 4A
Aliases HSPC134; VPS32A; C14orf123; chromosome 14 open reading frame 123; chromatin modifying protein 4A; CHMP4; SHA ......
Chromosomal Location14q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CHMP4A in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0510.8
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.2470.919
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0910.959
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.5810.0469
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1530.921
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.120.554
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0150.952
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0430.95
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0970.909
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0640.977
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.5150.877
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0110.853
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolCHMP4A
Namecharged multivesicular body protein 4A
Aliases HSPC134; VPS32A; C14orf123; chromosome 14 open reading frame 123; chromatin modifying protein 4A; CHMP4; SHA ......
Chromosomal Location14q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CHMP4A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCHMP4A
Namecharged multivesicular body protein 4A
Aliases HSPC134; VPS32A; C14orf123; chromosome 14 open reading frame 123; chromatin modifying protein 4A; CHMP4; SHA ......
Chromosomal Location14q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CHMP4A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CHMP4A.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCHMP4A
Namecharged multivesicular body protein 4A
Aliases HSPC134; VPS32A; C14orf123; chromosome 14 open reading frame 123; chromatin modifying protein 4A; CHMP4; SHA ......
Chromosomal Location14q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CHMP4A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCHMP4A
Namecharged multivesicular body protein 4A
Aliases HSPC134; VPS32A; C14orf123; chromosome 14 open reading frame 123; chromatin modifying protein 4A; CHMP4; SHA ......
Chromosomal Location14q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CHMP4A expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCHMP4A
Namecharged multivesicular body protein 4A
Aliases HSPC134; VPS32A; C14orf123; chromosome 14 open reading frame 123; chromatin modifying protein 4A; CHMP4; SHA ......
Chromosomal Location14q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CHMP4A and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCHMP4A
Namecharged multivesicular body protein 4A
Aliases HSPC134; VPS32A; C14orf123; chromosome 14 open reading frame 123; chromatin modifying protein 4A; CHMP4; SHA ......
Chromosomal Location14q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CHMP4A collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.