TISIDB

Summary
Symbol	CKS1B
Name	CDC28 protein kinase regulatory subunit 1B
Aliases	ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ......
Chromosomal Location	1q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	-
Domain	PF01111 Cyclin-dependent kinase regulatory subunit
Function	Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

> Gene Ontology [ TOP ]
Biological Process	GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0007346 regulation of mitotic cell cycle GO:0033674 positive regulation of kinase activity GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045787 positive regulation of cell cycle GO:0045860 positive regulation of protein kinase activity GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:1904029 regulation of cyclin-dependent protein kinase activity GO:1904031 positive regulation of cyclin-dependent protein kinase activity
Molecular Function	GO:0008047 enzyme activator activity GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity GO:0019207 kinase regulator activity GO:0019209 kinase activator activity GO:0019887 protein kinase regulator activity GO:0030295 protein kinase activator activity GO:0032182 ubiquitin-like protein binding GO:0042393 histone binding GO:0043130 ubiquitin binding GO:0043539 protein serine/threonine kinase activator activity GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity
Cellular Component	GO:0000151 ubiquitin ligase complex GO:0000307 cyclin-dependent protein kinase holoenzyme complex GO:0019005 SCF ubiquitin ligase complex GO:0031461 cullin-RING ubiquitin ligase complex GO:0061695 transferase complex, transferring phosphorus-containing groups GO:1902554 serine/threonine protein kinase complex GO:1902911 protein kinase complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-69656: Cyclin A R-HSA-69231: Cyclin D associated events in G1 R-HSA-69202: Cyclin E associated events during G1/S transition R-HSA-69236: G1 Phase R-HSA-69206: G1/S Transition R-HSA-453279: Mitotic G1-G1/S phases R-HSA-69242: S Phase R-HSA-187577: SCF(Skp2)-mediated degradation of p27/p21

Summary
Symbol	CKS1B
Name	CDC28 protein kinase regulatory subunit 1B
Aliases	ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ......
Chromosomal Location	1q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between CKS1B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between CKS1B and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
25597412	Non-Small Cell Lung Carcinoma	Inhibit immunity (T cell function)	Our discoveries suggest that the miR-197/CKS1B/STAT3-mediated network can drive tumor PD-L1 expression as a biomarker of this cascade, and miR-197 replacement therapy may be a potential treatment strategy for chemoresistant NSCLC.

Summary
Symbol	CKS1B
Name	CDC28 protein kinase regulatory subunit 1B
Aliases	ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ......
Chromosomal Location	1q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of CKS1B in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	logFC: -2.34; FDR: 0.00722	Resistant to T cell-mediated killing
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	CKS1B
Name	CDC28 protein kinase regulatory subunit 1B
Aliases	ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ......
Chromosomal Location	1q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of CKS1B in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.428	0.127
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.479	0.871
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.399	0.862
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.261	0.445
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.541	0.585
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.095	0.939
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.062	0.88
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.417	0.795
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.636	0.713
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.551	0.786
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.531	0.864
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.46	0.00177

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of CKS1B in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	1.4	-1.4	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	1.7	-1.7	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	6.2	-6.2	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	1

Summary
Symbol	CKS1B
Name	CDC28 protein kinase regulatory subunit 1B
Aliases	ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ......
Chromosomal Location	1q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CKS1B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	CKS1B
Name	CDC28 protein kinase regulatory subunit 1B
Aliases	ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ......
Chromosomal Location	1q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CKS1B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CKS1B. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	CKS1B
Name	CDC28 protein kinase regulatory subunit 1B
Aliases	ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ......
Chromosomal Location	1q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CKS1B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	CKS1B
Name	CDC28 protein kinase regulatory subunit 1B
Aliases	ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ......
Chromosomal Location	1q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of CKS1B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	CKS1B
Name	CDC28 protein kinase regulatory subunit 1B
Aliases	ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ......
Chromosomal Location	1q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between CKS1B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	CKS1B
Name	CDC28 protein kinase regulatory subunit 1B
Aliases	ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ......
Chromosomal Location	1q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting CKS1B collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting CKS1B.

ID	Name	Drug Type	Targets	#Targets
DB00472	Fluoxetine	Small Molecule	CKS1B, HTR2C, KCNH2, SLC6A4	4
DB02681	Meta Vanadate	Small Molecule	CKS1B	1

Browse CKS1B