Browse CNIH2

Summary
SymbolCNIH2
Namecornichon family AMPA receptor auxiliary protein 2
Aliases MGC50896; CNIH-2; cornichon homolog 2 (Drosophila); cornichon homolog 2; Cornichon-like protein; Protein cor ......
Chromosomal Location11q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Endoplasmic reticulum membrane Multi-pass membrane protein Cell junction, synapse, postsynaptic cell membrane Multi-pass membrane protein Cell projection, dendrite Cell projection, dendritic spine Cell junction, synapse, postsynaptic cell membrane, postsynaptic density Note=Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells).
Domain PF03311 Cornichon protein
Function

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors.

> Gene Ontology
 
Biological Process GO:0006888 ER to Golgi vesicle-mediated transport
GO:0006900 membrane budding
GO:0006901 vesicle coating
GO:0006903 vesicle targeting
GO:0007018 microtubule-based movement
GO:0007215 glutamate receptor signaling pathway
GO:0007270 neuron-neuron synaptic transmission
GO:0008088 axo-dendritic transport
GO:0008089 anterograde axonal transport
GO:0010469 regulation of receptor activity
GO:0010970 transport along microtubule
GO:0016050 vesicle organization
GO:0022898 regulation of transmembrane transporter activity
GO:0030705 cytoskeleton-dependent intracellular transport
GO:0031503 protein complex localization
GO:0032386 regulation of intracellular transport
GO:0032387 negative regulation of intracellular transport
GO:0032409 regulation of transporter activity
GO:0032412 regulation of ion transmembrane transporter activity
GO:0032886 regulation of microtubule-based process
GO:0034762 regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0035249 synaptic transmission, glutamatergic
GO:0035418 protein localization to synapse
GO:0042391 regulation of membrane potential
GO:0047496 vesicle transport along microtubule
GO:0048193 Golgi vesicle transport
GO:0048199 vesicle targeting, to, from or within Golgi
GO:0048207 vesicle targeting, rough ER to cis-Golgi
GO:0048208 COPII vesicle coating
GO:0048489 synaptic vesicle transport
GO:0048490 anterograde synaptic vesicle transport
GO:0051051 negative regulation of transport
GO:0051271 negative regulation of cellular component movement
GO:0051640 organelle localization
GO:0051648 vesicle localization
GO:0051650 establishment of vesicle localization
GO:0051656 establishment of organelle localization
GO:0051668 localization within membrane
GO:0060627 regulation of vesicle-mediated transport
GO:0060632 regulation of microtubule-based movement
GO:0072384 organelle transport along microtubule
GO:0090114 COPII-coated vesicle budding
GO:0097120 receptor localization to synapse
GO:0097479 synaptic vesicle localization
GO:0097480 establishment of synaptic vesicle localization
GO:0098930 axonal transport
GO:0099514 synaptic vesicle cytoskeletal transport
GO:0099517 synaptic vesicle transport along microtubule
GO:0099518 vesicle cytoskeletal trafficking
GO:0099601 regulation of neurotransmitter receptor activity
GO:1900449 regulation of glutamate receptor signaling pathway
GO:1901608 regulation of vesicle transport along microtubule
GO:1901609 negative regulation of vesicle transport along microtubule
GO:1902473 regulation of protein localization to synapse
GO:1902513 regulation of organelle transport along microtubule
GO:1902683 regulation of receptor localization to synapse
GO:1902684 negative regulation of receptor localization to synapse
GO:1902803 regulation of synaptic vesicle transport
GO:1902804 negative regulation of synaptic vesicle transport
GO:1903742 regulation of anterograde synaptic vesicle transport
GO:1903743 negative regulation of anterograde synaptic vesicle transport
GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
Molecular Function -
Cellular Component GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0008328 ionotropic glutamate receptor complex
GO:0012507 ER to Golgi transport vesicle membrane
GO:0014069 postsynaptic density
GO:0030133 transport vesicle
GO:0030134 ER to Golgi transport vesicle
GO:0030135 coated vesicle
GO:0030425 dendrite
GO:0030658 transport vesicle membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0030662 coated vesicle membrane
GO:0032281 AMPA glutamate receptor complex
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0034702 ion channel complex
GO:0043197 dendritic spine
GO:0043198 dendritic shaft
GO:0043235 receptor complex
GO:0044309 neuron spine
GO:0045211 postsynaptic membrane
GO:0060076 excitatory synapse
GO:0097060 synaptic membrane
GO:0098794 postsynapse
GO:0098802 plasma membrane receptor complex
GO:0098878 neurotransmitter receptor complex
GO:0099572 postsynaptic specialization
GO:1902495 transmembrane transporter complex
GO:1990351 transporter complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-446203: Asparagine N-linked glycosylation
R-HSA-204005: COPII (Coat Protein 2) Mediated Vesicle Transport
R-HSA-5694530: Cargo concentration in the ER
R-HSA-199977: ER to Golgi Anterograde Transport
R-HSA-199991: Membrane Trafficking
R-HSA-392499: Metabolism of proteins
R-HSA-597592: Post-translational protein modification
R-HSA-948021: Transport to the Golgi and subsequent modification
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolCNIH2
Namecornichon family AMPA receptor auxiliary protein 2
Aliases MGC50896; CNIH-2; cornichon homolog 2 (Drosophila); cornichon homolog 2; Cornichon-like protein; Protein cor ......
Chromosomal Location11q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CNIH2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolCNIH2
Namecornichon family AMPA receptor auxiliary protein 2
Aliases MGC50896; CNIH-2; cornichon homolog 2 (Drosophila); cornichon homolog 2; Cornichon-like protein; Protein cor ......
Chromosomal Location11q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CNIH2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCNIH2
Namecornichon family AMPA receptor auxiliary protein 2
Aliases MGC50896; CNIH-2; cornichon homolog 2 (Drosophila); cornichon homolog 2; Cornichon-like protein; Protein cor ......
Chromosomal Location11q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CNIH2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.4630.255
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.7450.276
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2740.706
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.4760.318
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.6640.485
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2550.856
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0970.805
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1490.806
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1470.823
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1630.787
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.2840.715
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.6450.00018
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolCNIH2
Namecornichon family AMPA receptor auxiliary protein 2
Aliases MGC50896; CNIH-2; cornichon homolog 2 (Drosophila); cornichon homolog 2; Cornichon-like protein; Protein cor ......
Chromosomal Location11q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CNIH2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCNIH2
Namecornichon family AMPA receptor auxiliary protein 2
Aliases MGC50896; CNIH-2; cornichon homolog 2 (Drosophila); cornichon homolog 2; Cornichon-like protein; Protein cor ......
Chromosomal Location11q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CNIH2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CNIH2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCNIH2
Namecornichon family AMPA receptor auxiliary protein 2
Aliases MGC50896; CNIH-2; cornichon homolog 2 (Drosophila); cornichon homolog 2; Cornichon-like protein; Protein cor ......
Chromosomal Location11q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CNIH2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCNIH2
Namecornichon family AMPA receptor auxiliary protein 2
Aliases MGC50896; CNIH-2; cornichon homolog 2 (Drosophila); cornichon homolog 2; Cornichon-like protein; Protein cor ......
Chromosomal Location11q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CNIH2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCNIH2
Namecornichon family AMPA receptor auxiliary protein 2
Aliases MGC50896; CNIH-2; cornichon homolog 2 (Drosophila); cornichon homolog 2; Cornichon-like protein; Protein cor ......
Chromosomal Location11q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CNIH2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCNIH2
Namecornichon family AMPA receptor auxiliary protein 2
Aliases MGC50896; CNIH-2; cornichon homolog 2 (Drosophila); cornichon homolog 2; Cornichon-like protein; Protein cor ......
Chromosomal Location11q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CNIH2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.