Browse CNTN2

Summary
SymbolCNTN2
Namecontactin 2 (axonal)
Aliases TAG-1; TAX1; TAX; AXT; FAME5; axonal glycoprotein TAG-1; axonin-1 cell adhesion molecule; contactin 2 (trans ......
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane; Lipid-anchor, GPI-anchor. Note=Attached to the neuronal membrane by a GPI-anchor and is also released from neurons.
Domain PF00041 Fibronectin type III domain
PF07679 Immunoglobulin I-set domain
Function

In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion.

> Gene Ontology
 
Biological Process GO:0000226 microtubule cytoskeleton organization
GO:0001764 neuron migration
GO:0001973 adenosine receptor signaling pathway
GO:0006898 receptor-mediated endocytosis
GO:0007272 ensheathment of neurons
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007413 axonal fasciculation
GO:0007611 learning or memory
GO:0007612 learning
GO:0007626 locomotory behavior
GO:0007628 adult walking behavior
GO:0008037 cell recognition
GO:0008038 neuron recognition
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0008344 adult locomotory behavior
GO:0008366 axon ensheathment
GO:0010001 glial cell differentiation
GO:0010721 negative regulation of cell development
GO:0010769 regulation of cell morphogenesis involved in differentiation
GO:0010954 positive regulation of protein processing
GO:0010975 regulation of neuron projection development
GO:0014003 oligodendrocyte development
GO:0014013 regulation of gliogenesis
GO:0016485 protein processing
GO:0021537 telencephalon development
GO:0021700 developmental maturation
GO:0021782 glial cell development
GO:0021826 substrate-independent telencephalic tangential migration
GO:0021830 interneuron migration from the subpallium to the cortex
GO:0021843 substrate-independent telencephalic tangential interneuron migration
GO:0021853 cerebral cortex GABAergic interneuron migration
GO:0021872 forebrain generation of neurons
GO:0021879 forebrain neuron differentiation
GO:0021884 forebrain neuron development
GO:0021885 forebrain cell migration
GO:0021892 cerebral cortex GABAergic interneuron differentiation
GO:0021894 cerebral cortex GABAergic interneuron development
GO:0021895 cerebral cortex neuron differentiation
GO:0021953 central nervous system neuron differentiation
GO:0021954 central nervous system neuron development
GO:0022010 central nervous system myelination
GO:0022029 telencephalon cell migration
GO:0022604 regulation of cell morphogenesis
GO:0030534 adult behavior
GO:0030900 forebrain development
GO:0031133 regulation of axon diameter
GO:0031623 receptor internalization
GO:0032291 axon ensheathment in central nervous system
GO:0032535 regulation of cellular component size
GO:0032536 regulation of cell projection size
GO:0035587 purinergic receptor signaling pathway
GO:0035588 G-protein coupled purinergic receptor signaling pathway
GO:0042063 gliogenesis
GO:0042551 neuron maturation
GO:0042552 myelination
GO:0043112 receptor metabolic process
GO:0044708 single-organism behavior
GO:0045161 neuronal ion channel clustering
GO:0045163 clustering of voltage-gated potassium channels
GO:0045665 negative regulation of neuron differentiation
GO:0045685 regulation of glial cell differentiation
GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway
GO:0045862 positive regulation of proteolysis
GO:0048167 regulation of synaptic plasticity
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048469 cell maturation
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048708 astrocyte differentiation
GO:0048709 oligodendrocyte differentiation
GO:0048710 regulation of astrocyte differentiation
GO:0050768 negative regulation of neurogenesis
GO:0050770 regulation of axonogenesis
GO:0050804 modulation of synaptic transmission
GO:0050808 synapse organization
GO:0050890 cognition
GO:0051604 protein maturation
GO:0051961 negative regulation of nervous system development
GO:0060167 regulation of adenosine receptor signaling pathway
GO:0060168 positive regulation of adenosine receptor signaling pathway
GO:0061564 axon development
GO:0070613 regulation of protein processing
GO:0071205 protein localization to juxtaparanode region of axon
GO:0071206 establishment of protein localization to juxtaparanode region of axon
GO:0090066 regulation of anatomical structure size
GO:0090659 walking behavior
GO:0097090 presynaptic membrane organization
GO:0097154 GABAergic neuron differentiation
GO:0097485 neuron projection guidance
GO:0099612 protein localization to axon
GO:1903317 regulation of protein maturation
GO:1903319 positive regulation of protein maturation
GO:1904936 interneuron migration
Molecular Function GO:0001948 glycoprotein binding
GO:0030246 carbohydrate binding
GO:0043621 protein self-association
Cellular Component GO:0008076 voltage-gated potassium channel complex
GO:0030424 axon
GO:0031225 anchored component of membrane
GO:0033267 axon part
GO:0033268 node of Ranvier
GO:0034702 ion channel complex
GO:0034703 cation channel complex
GO:0034705 potassium channel complex
GO:0043025 neuronal cell body
GO:0043209 myelin sheath
GO:0044224 juxtaparanode region of axon
GO:0044297 cell body
GO:0044304 main axon
GO:1902495 transmembrane transporter complex
GO:1990351 transporter complex
> KEGG and Reactome Pathway
 
KEGG hsa04514 Cell adhesion molecules (CAMs)
Reactome R-HSA-422475: Axon guidance
R-HSA-1266738: Developmental Biology
R-HSA-373760: L1CAM interactions
R-HSA-375165: NCAM signaling for neurite out-growth
R-HSA-419037: NCAM1 interactions
R-HSA-447038: NrCAM interactions
Summary
SymbolCNTN2
Namecontactin 2 (axonal)
Aliases TAG-1; TAX1; TAX; AXT; FAME5; axonal glycoprotein TAG-1; axonin-1 cell adhesion molecule; contactin 2 (trans ......
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CNTN2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between CNTN2 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
23733874Adult T-Cell Leukemia/LymphomaPromote immunity (infiltration); essential for immunotherapyIn these mice established with cells from a chronic-type patient, treatment by i.p. injection of autologous Tax-CTL resulted in greater infiltration of CD8-positive T cells into each ATL lesion. Thus, although the therapeutic effects were different for different ATL patients, to the best of our knowledge, this is the first report that adoptive therapy with Ag-specific CTL expanded from a cancer patient confers antitumor effects, leading to significant survival benefit for autologous primary cancer cell-bearing mice in vivo.
28011931Adult T-Cell Leukemia/LymphomaPromote immunityHTLV-1 Tax-Specific CTL Epitope-Pulsed Dendritic Cell Therapy Reduces Proviral Load in Infected Rats with Immune Tolerance against Tax. Even in the infected rats with immune unresponsiveness against Tax, Tax-specific CTL epitope-pulsed dendritic cell (DC) therapy reduced the PVL and induced Tax-specific CD8+T cells capable of proliferating and producing IFN-γ.
Summary
SymbolCNTN2
Namecontactin 2 (axonal)
Aliases TAG-1; TAX1; TAX; AXT; FAME5; axonal glycoprotein TAG-1; axonin-1 cell adhesion molecule; contactin 2 (trans ......
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CNTN2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCNTN2
Namecontactin 2 (axonal)
Aliases TAG-1; TAX1; TAX; AXT; FAME5; axonal glycoprotein TAG-1; axonin-1 cell adhesion molecule; contactin 2 (trans ......
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CNTN2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0930.798
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0730.955
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.120.939
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.6950.313
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.4860.693
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11121.1310.452
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.20.625
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.2470.685
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0160.952
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CNTN2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.74.1-0.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.75.1-1.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.55.93.61
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.79.1-1.41
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.33.71.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.17.71.41
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11139.109.10.458
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 6116.7016.71
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCNTN2
Namecontactin 2 (axonal)
Aliases TAG-1; TAX1; TAX; AXT; FAME5; axonal glycoprotein TAG-1; axonin-1 cell adhesion molecule; contactin 2 (trans ......
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CNTN2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCNTN2
Namecontactin 2 (axonal)
Aliases TAG-1; TAX1; TAX; AXT; FAME5; axonal glycoprotein TAG-1; axonin-1 cell adhesion molecule; contactin 2 (trans ......
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CNTN2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CNTN2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCNTN2
Namecontactin 2 (axonal)
Aliases TAG-1; TAX1; TAX; AXT; FAME5; axonal glycoprotein TAG-1; axonin-1 cell adhesion molecule; contactin 2 (trans ......
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CNTN2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCNTN2
Namecontactin 2 (axonal)
Aliases TAG-1; TAX1; TAX; AXT; FAME5; axonal glycoprotein TAG-1; axonin-1 cell adhesion molecule; contactin 2 (trans ......
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CNTN2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCNTN2
Namecontactin 2 (axonal)
Aliases TAG-1; TAX1; TAX; AXT; FAME5; axonal glycoprotein TAG-1; axonin-1 cell adhesion molecule; contactin 2 (trans ......
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CNTN2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCNTN2
Namecontactin 2 (axonal)
Aliases TAG-1; TAX1; TAX; AXT; FAME5; axonal glycoprotein TAG-1; axonin-1 cell adhesion molecule; contactin 2 (trans ......
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CNTN2 collected from DrugBank database.
> Drugs from DrugBank database
 

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