TISIDB

Summary
Symbol	CNTNAP2
Name	contactin associated protein-like 2
Aliases	Caspr2; KIAA0868; AUTS15; CDFE; PTHSL1; cell recognition molecule Caspr2; homolog of Drosophila neurexin IV; ......
Chromosomal Location	7q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Membrane Single-pass type I membrane protein Cell projection, axon Cell junction, paranodal septate junction Note=Expressed in the juxtaparadonal region.
Domain	PF00754 F5/8 type C domain PF02210 Laminin G domain
Function	Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction.

> Gene Ontology [ TOP ]
Biological Process	GO:0007611 learning or memory GO:0007612 learning GO:0007638 mechanosensory behavior GO:0008037 cell recognition GO:0008038 neuron recognition GO:0009612 response to mechanical stimulus GO:0010996 response to auditory stimulus GO:0019226 transmission of nerve impulse GO:0021536 diencephalon development GO:0021537 telencephalon development GO:0021543 pallium development GO:0021544 subpallium development GO:0021700 developmental maturation GO:0021756 striatum development GO:0021761 limbic system development GO:0021794 thalamus development GO:0021987 cerebral cortex development GO:0030534 adult behavior GO:0030900 forebrain development GO:0031223 auditory behavior GO:0035176 social behavior GO:0035637 multicellular organismal signaling GO:0042297 vocal learning GO:0042551 neuron maturation GO:0044708 single-organism behavior GO:0045161 neuronal ion channel clustering GO:0045163 clustering of voltage-gated potassium channels GO:0048469 cell maturation GO:0050890 cognition GO:0051703 intraspecies interaction between organisms GO:0051705 multi-organism behavior GO:0071109 superior temporal gyrus development GO:0071205 protein localization to juxtaparanode region of axon GO:0071625 vocalization behavior GO:0098596 imitative learning GO:0098597 observational learning GO:0098598 learned vocalization behavior or vocal learning GO:0099612 protein localization to axon
Molecular Function	-
Cellular Component	GO:0005769 early endosome GO:0008076 voltage-gated potassium channel complex GO:0030424 axon GO:0030425 dendrite GO:0030673 axolemma GO:0031252 cell leading edge GO:0031253 cell projection membrane GO:0031256 leading edge membrane GO:0032589 neuron projection membrane GO:0033267 axon part GO:0034702 ion channel complex GO:0034703 cation channel complex GO:0034705 potassium channel complex GO:0043025 neuronal cell body GO:0043204 perikaryon GO:0044224 juxtaparanode region of axon GO:0044297 cell body GO:0044304 main axon GO:1902495 transmembrane transporter complex GO:1990351 transporter complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04514 Cell adhesion molecules (CAMs)
Reactome	-

Summary
Symbol	CNTNAP2
Name	contactin associated protein-like 2
Aliases	Caspr2; KIAA0868; AUTS15; CDFE; PTHSL1; cell recognition molecule Caspr2; homolog of Drosophila neurexin IV; ......
Chromosomal Location	7q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between CNTNAP2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	CNTNAP2
Name	contactin associated protein-like 2
Aliases	Caspr2; KIAA0868; AUTS15; CDFE; PTHSL1; cell recognition molecule Caspr2; homolog of Drosophila neurexin IV; ......
Chromosomal Location	7q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of CNTNAP2 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	CNTNAP2
Name	contactin associated protein-like 2
Aliases	Caspr2; KIAA0868; AUTS15; CDFE; PTHSL1; cell recognition molecule Caspr2; homolog of Drosophila neurexin IV; ......
Chromosomal Location	7q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of CNTNAP2 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0	1
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0	1
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0	1
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.394	0.472
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-1.063	0.41
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.444	0.758
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.748	0.324
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.673	0.605
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.701	0.587
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.912	0.113
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.866	0.0104
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.502	0.156

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of CNTNAP2 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	7.1	5.9	1.2	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	10	0	10	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	7.1	-7.1	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	29.6	9.6	20	0.0237
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	29.6	11.9	17.7	0.065
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	33.3	11.8	21.5	0.148
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	25	0	25	0.473
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	38.5	18.2	20.3	0.386
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	0	11.1	0.36
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	25	0	25	0.364
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	18.4	7.4	11	0.285
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	13.6	7.7	5.9	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	25	7.1	17.9	0.336
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	7.7	-7.7	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	8.3	-8.3	1

Summary
Symbol	CNTNAP2
Name	contactin associated protein-like 2
Aliases	Caspr2; KIAA0868; AUTS15; CDFE; PTHSL1; cell recognition molecule Caspr2; homolog of Drosophila neurexin IV; ......
Chromosomal Location	7q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CNTNAP2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	CNTNAP2
Name	contactin associated protein-like 2
Aliases	Caspr2; KIAA0868; AUTS15; CDFE; PTHSL1; cell recognition molecule Caspr2; homolog of Drosophila neurexin IV; ......
Chromosomal Location	7q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CNTNAP2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CNTNAP2. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	CNTNAP2
Name	contactin associated protein-like 2
Aliases	Caspr2; KIAA0868; AUTS15; CDFE; PTHSL1; cell recognition molecule Caspr2; homolog of Drosophila neurexin IV; ......
Chromosomal Location	7q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CNTNAP2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	CNTNAP2
Name	contactin associated protein-like 2
Aliases	Caspr2; KIAA0868; AUTS15; CDFE; PTHSL1; cell recognition molecule Caspr2; homolog of Drosophila neurexin IV; ......
Chromosomal Location	7q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of CNTNAP2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	CNTNAP2
Name	contactin associated protein-like 2
Aliases	Caspr2; KIAA0868; AUTS15; CDFE; PTHSL1; cell recognition molecule Caspr2; homolog of Drosophila neurexin IV; ......
Chromosomal Location	7q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between CNTNAP2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	CNTNAP2
Name	contactin associated protein-like 2
Aliases	Caspr2; KIAA0868; AUTS15; CDFE; PTHSL1; cell recognition molecule Caspr2; homolog of Drosophila neurexin IV; ......
Chromosomal Location	7q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting CNTNAP2 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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