TISIDB

Summary
Symbol	COL11A1
Name	collagen, type XI, alpha 1
Aliases	STL2; CO11A1; collagen XI, alpha-1 polypeptide; COLL6; Collagen alpha-1(XI) chain
Chromosomal Location	1p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Secreted, extracellular space, extracellular matrix
Domain	PF01410 Fibrillar collagen C-terminal domain PF01391 Collagen triple helix repeat (20 copies) PF02210 Laminin G domain
Function	May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.

> Gene Ontology [ TOP ]
Biological Process	GO:0001501 skeletal system development GO:0001502 cartilage condensation GO:0001503 ossification GO:0001704 formation of primary germ layer GO:0001706 endoderm formation GO:0002062 chondrocyte differentiation GO:0002063 chondrocyte development GO:0003007 heart morphogenesis GO:0003205 cardiac chamber development GO:0003206 cardiac chamber morphogenesis GO:0003208 cardiac ventricle morphogenesis GO:0003229 ventricular cardiac muscle tissue development GO:0003231 cardiac ventricle development GO:0006029 proteoglycan metabolic process GO:0007369 gastrulation GO:0007423 sensory organ development GO:0007492 endoderm development GO:0007507 heart development GO:0007517 muscle organ development GO:0007601 visual perception GO:0007605 sensory perception of sound GO:0009100 glycoprotein metabolic process GO:0009581 detection of external stimulus GO:0009582 detection of abiotic stimulus GO:0009612 response to mechanical stimulus GO:0014706 striated muscle tissue development GO:0030198 extracellular matrix organization GO:0030199 collagen fibril organization GO:0030574 collagen catabolic process GO:0032963 collagen metabolic process GO:0035987 endodermal cell differentiation GO:0035989 tendon development GO:0042471 ear morphogenesis GO:0042472 inner ear morphogenesis GO:0043062 extracellular structure organization GO:0043583 ear development GO:0044236 multicellular organism metabolic process GO:0044243 multicellular organism catabolic process GO:0044259 multicellular organismal macromolecule metabolic process GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048644 muscle organ morphogenesis GO:0048704 embryonic skeletal system morphogenesis GO:0048705 skeletal system morphogenesis GO:0048706 embryonic skeletal system development GO:0048738 cardiac muscle tissue development GO:0048839 inner ear development GO:0050910 detection of mechanical stimulus involved in sensory perception of sound GO:0050953 sensory perception of light stimulus GO:0050954 sensory perception of mechanical stimulus GO:0050974 detection of mechanical stimulus involved in sensory perception GO:0050982 detection of mechanical stimulus GO:0051216 cartilage development GO:0055008 cardiac muscle tissue morphogenesis GO:0055010 ventricular cardiac muscle tissue morphogenesis GO:0060415 muscle tissue morphogenesis GO:0060537 muscle tissue development GO:0061448 connective tissue development GO:0090596 sensory organ morphogenesis GO:0098743 cell aggregation
Molecular Function	GO:0005201 extracellular matrix structural constituent GO:0030674 protein binding, bridging GO:0050840 extracellular matrix binding GO:0060090 binding, bridging
Cellular Component	GO:0005578 proteinaceous extracellular matrix GO:0005581 collagen trimer GO:0005583 fibrillar collagen trimer GO:0005592 collagen type XI trimer GO:0005788 endoplasmic reticulum lumen GO:0044420 extracellular matrix component GO:0098643 banded collagen fibril GO:0098644 complex of collagen trimers

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04974 Protein digestion and absorption
Reactome	R-HSA-2022090: Assembly of collagen fibrils and other multimeric structures R-HSA-1650814: Collagen biosynthesis and modifying enzymes R-HSA-8948216: Collagen chain trimerization R-HSA-1474290: Collagen formation R-HSA-1474244: Extracellular matrix organization

Summary
Symbol	COL11A1
Name	collagen, type XI, alpha 1
Aliases	STL2; CO11A1; collagen XI, alpha-1 polypeptide; COLL6; Collagen alpha-1(XI) chain
Chromosomal Location	1p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between COL11A1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	COL11A1
Name	collagen, type XI, alpha 1
Aliases	STL2; CO11A1; collagen XI, alpha-1 polypeptide; COLL6; Collagen alpha-1(XI) chain
Chromosomal Location	1p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of COL11A1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	COL11A1
Name	collagen, type XI, alpha 1
Aliases	STL2; CO11A1; collagen XI, alpha-1 polypeptide; COLL6; Collagen alpha-1(XI) chain
Chromosomal Location	1p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of COL11A1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-1.46	0.0583
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.605	0.691
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-2.079	0.074
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-1.322	0.0203
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-1.237	0.527
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-1.427	0.573
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.306	0.751
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-1.383	0.385
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.712	0.701
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.409	0.8
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	2.387	0.228
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.056	0.902

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of COL11A1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	28.6	0	28.6	0.0318
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	40	0	40	0.497
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	14.8	13.7	1.1	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	14.8	16.9	-2.1	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	23.8	17.6	6.2	0.709
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	38.5	27.3	11.2	0.679
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	0	11.1	0.36
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	20	0	20	0.357
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	10.5	3.7	6.8	0.393
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	13.6	0	13.6	0.279
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	6.2	7.1	-0.9	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	COL11A1
Name	collagen, type XI, alpha 1
Aliases	STL2; CO11A1; collagen XI, alpha-1 polypeptide; COLL6; Collagen alpha-1(XI) chain
Chromosomal Location	1p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of COL11A1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	COL11A1
Name	collagen, type XI, alpha 1
Aliases	STL2; CO11A1; collagen XI, alpha-1 polypeptide; COLL6; Collagen alpha-1(XI) chain
Chromosomal Location	1p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of COL11A1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by COL11A1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	COL11A1
Name	collagen, type XI, alpha 1
Aliases	STL2; CO11A1; collagen XI, alpha-1 polypeptide; COLL6; Collagen alpha-1(XI) chain
Chromosomal Location	1p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of COL11A1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	COL11A1
Name	collagen, type XI, alpha 1
Aliases	STL2; CO11A1; collagen XI, alpha-1 polypeptide; COLL6; Collagen alpha-1(XI) chain
Chromosomal Location	1p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of COL11A1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	COL11A1
Name	collagen, type XI, alpha 1
Aliases	STL2; CO11A1; collagen XI, alpha-1 polypeptide; COLL6; Collagen alpha-1(XI) chain
Chromosomal Location	1p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between COL11A1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	COL11A1
Name	collagen, type XI, alpha 1
Aliases	STL2; CO11A1; collagen XI, alpha-1 polypeptide; COLL6; Collagen alpha-1(XI) chain
Chromosomal Location	1p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting COL11A1 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse COL11A1