Browse COL1A2

Summary
SymbolCOL1A2
Namecollagen, type I, alpha 2
Aliases alpha 2(I)-collagen; alpha-2 collagen type I; type I procollagen; collagen I, alpha-2 polypeptide; collagen ......
Chromosomal Location7q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted, extracellular space, extracellular matrix
Domain PF01410 Fibrillar collagen C-terminal domain
PF01391 Collagen triple helix repeat (20 copies)
Function

Type I collagen is a member of group I collagen (fibrillar forming collagen).

> Gene Ontology
 
Biological Process GO:0001101 response to acid chemical
GO:0001501 skeletal system development
GO:0003013 circulatory system process
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007266 Rho protein signal transduction
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0008015 blood circulation
GO:0008217 regulation of blood pressure
GO:0030168 platelet activation
GO:0030198 extracellular matrix organization
GO:0030199 collagen fibril organization
GO:0030574 collagen catabolic process
GO:0032963 collagen metabolic process
GO:0042476 odontogenesis
GO:0043062 extracellular structure organization
GO:0043200 response to amino acid
GO:0043588 skin development
GO:0043589 skin morphogenesis
GO:0044236 multicellular organism metabolic process
GO:0044243 multicellular organism catabolic process
GO:0044259 multicellular organismal macromolecule metabolic process
GO:0050817 coagulation
GO:0050878 regulation of body fluid levels
GO:0050900 leukocyte migration
GO:0051259 protein oligomerization
GO:0051291 protein heterooligomerization
GO:0070206 protein trimerization
GO:0070208 protein heterotrimerization
GO:0071229 cellular response to acid chemical
GO:0071230 cellular response to amino acid stimulus
GO:0071417 cellular response to organonitrogen compound
GO:0071559 response to transforming growth factor beta
GO:0071560 cellular response to transforming growth factor beta stimulus
Molecular Function GO:0005201 extracellular matrix structural constituent
GO:0019838 growth factor binding
GO:0030674 protein binding, bridging
GO:0046332 SMAD binding
GO:0048407 platelet-derived growth factor binding
GO:0060090 binding, bridging
Cellular Component GO:0005578 proteinaceous extracellular matrix
GO:0005581 collagen trimer
GO:0005583 fibrillar collagen trimer
GO:0005584 collagen type I trimer
GO:0005788 endoplasmic reticulum lumen
GO:0044420 extracellular matrix component
GO:0098643 banded collagen fibril
GO:0098644 complex of collagen trimers
> KEGG and Reactome Pathway
 
KEGG hsa04151 PI3K-Akt signaling pathway
hsa04510 Focal adhesion
hsa04512 ECM-receptor interaction
hsa04611 Platelet activation
hsa04974 Protein digestion and absorption
Reactome R-HSA-2022090: Assembly of collagen fibrils and other multimeric structures
R-HSA-2173782: Binding and Uptake of Ligands by Scavenger Receptors
R-HSA-1650814: Collagen biosynthesis and modifying enzymes
R-HSA-8948216: Collagen chain trimerization
R-HSA-1474290: Collagen formation
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-1474244: Extracellular matrix organization
R-HSA-168256: Immune System
R-HSA-6785807: Interleukin-4 and 13 signaling
R-HSA-3000480: Scavenging by Class A Receptors
R-HSA-449147: Signaling by Interleukins
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolCOL1A2
Namecollagen, type I, alpha 2
Aliases alpha 2(I)-collagen; alpha-2 collagen type I; type I procollagen; collagen I, alpha-2 polypeptide; collagen ......
Chromosomal Location7q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between COL1A2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolCOL1A2
Namecollagen, type I, alpha 2
Aliases alpha 2(I)-collagen; alpha-2 collagen type I; type I procollagen; collagen I, alpha-2 polypeptide; collagen ......
Chromosomal Location7q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of COL1A2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCOL1A2
Namecollagen, type I, alpha 2
Aliases alpha 2(I)-collagen; alpha-2 collagen type I; type I procollagen; collagen I, alpha-2 polypeptide; collagen ......
Chromosomal Location7q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of COL1A2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.2310.0765
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.6330.678
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.9180.724
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.9310.113
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.9930.805
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.8490.871
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0910.906
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.6280.81
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.3260.917
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 482.180.449
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 284.4420.264
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.170.446
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of COL1A2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277322.24.118.10.011
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275922.25.117.10.0245
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)2117195.913.10.355
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131123.19.1140.596
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.907.90.26
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolCOL1A2
Namecollagen, type I, alpha 2
Aliases alpha 2(I)-collagen; alpha-2 collagen type I; type I procollagen; collagen I, alpha-2 polypeptide; collagen ......
Chromosomal Location7q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of COL1A2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCOL1A2
Namecollagen, type I, alpha 2
Aliases alpha 2(I)-collagen; alpha-2 collagen type I; type I procollagen; collagen I, alpha-2 polypeptide; collagen ......
Chromosomal Location7q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of COL1A2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by COL1A2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCOL1A2
Namecollagen, type I, alpha 2
Aliases alpha 2(I)-collagen; alpha-2 collagen type I; type I procollagen; collagen I, alpha-2 polypeptide; collagen ......
Chromosomal Location7q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of COL1A2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCOL1A2
Namecollagen, type I, alpha 2
Aliases alpha 2(I)-collagen; alpha-2 collagen type I; type I procollagen; collagen I, alpha-2 polypeptide; collagen ......
Chromosomal Location7q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of COL1A2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCOL1A2
Namecollagen, type I, alpha 2
Aliases alpha 2(I)-collagen; alpha-2 collagen type I; type I procollagen; collagen I, alpha-2 polypeptide; collagen ......
Chromosomal Location7q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between COL1A2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCOL1A2
Namecollagen, type I, alpha 2
Aliases alpha 2(I)-collagen; alpha-2 collagen type I; type I procollagen; collagen I, alpha-2 polypeptide; collagen ......
Chromosomal Location7q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting COL1A2 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting COL1A2.
ID Name Drug Type Targets #Targets
DB00048Collagenase clostridium histolyticumBiotechCOL1A1, COL1A2, COL2A1, COL3A14