Browse CORIN

Summary
SymbolCORIN
Namecorin, serine peptidase
Aliases PRSC; ATC2; TMPRSS10; corin, serine protease; PEE5; heart-specific serine proteinase ATC2; pro-ANP-convertas ......
Chromosomal Location4p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Single-pass type II membrane protein Note=May easily detached from the endothelial cell membrane.; SUBCELLULAR LOCATION: Isoform 2: Cell membrane; Single-pass type II membrane protein. Note=Less efficiently targeted to the cell membrane compared to isoform 1.; SUBCELLULAR LOCATION: Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment: Secreted. Note=Soluble form produced following cleavage by ADAM10.; SUBCELLULAR LOCATION: Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment: Secreted. Note=Soluble form produced following autocatalytic cleavage.; SUBCELLULAR LOCATION: Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment: Secreted. Note=Soluble form produced following autocatalytic cleavage.
Domain PF01392 Fz domain
PF00057 Low-density lipoprotein receptor domain class A
PF15494 Scavenger receptor cysteine-rich domain
PF00089 Trypsin
Function

Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide.; FUNCTION: Isoform 2: has weaker endopeptidase activity compared to isoform 1.

> Gene Ontology
 
Biological Process GO:0001990 regulation of systemic arterial blood pressure by hormone
GO:0003013 circulatory system process
GO:0003014 renal system process
GO:0003015 heart process
GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal
GO:0003050 regulation of systemic arterial blood pressure by atrial natriuretic peptide
GO:0003073 regulation of systemic arterial blood pressure
GO:0007565 female pregnancy
GO:0007588 excretion
GO:0008015 blood circulation
GO:0008016 regulation of heart contraction
GO:0008217 regulation of blood pressure
GO:0010817 regulation of hormone levels
GO:0016485 protein processing
GO:0016486 peptide hormone processing
GO:0032844 regulation of homeostatic process
GO:0035637 multicellular organismal signaling
GO:0035812 renal sodium excretion
GO:0035813 regulation of renal sodium excretion
GO:0042445 hormone metabolic process
GO:0044057 regulation of system process
GO:0044062 regulation of excretion
GO:0044706 multi-multicellular organism process
GO:0050886 endocrine process
GO:0051604 protein maturation
GO:0055067 monovalent inorganic cation homeostasis
GO:0055078 sodium ion homeostasis
GO:0060047 heart contraction
GO:0061337 cardiac conduction
GO:0098801 regulation of renal system process
GO:1903522 regulation of blood circulation
GO:1903779 regulation of cardiac conduction
GO:2000021 regulation of ion homeostasis
Molecular Function GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0017171 serine hydrolase activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-5576891: Cardiac conduction
R-HSA-397014: Muscle contraction
R-HSA-5578768: Physiological factors
Summary
SymbolCORIN
Namecorin, serine peptidase
Aliases PRSC; ATC2; TMPRSS10; corin, serine protease; PEE5; heart-specific serine proteinase ATC2; pro-ANP-convertas ......
Chromosomal Location4p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CORIN and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolCORIN
Namecorin, serine peptidase
Aliases PRSC; ATC2; TMPRSS10; corin, serine protease; PEE5; heart-specific serine proteinase ATC2; pro-ANP-convertas ......
Chromosomal Location4p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CORIN in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCORIN
Namecorin, serine peptidase
Aliases PRSC; ATC2; TMPRSS10; corin, serine protease; PEE5; heart-specific serine proteinase ATC2; pro-ANP-convertas ......
Chromosomal Location4p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CORIN in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.5910.0849
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.8230.532
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.30.85
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0260.964
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2680.755
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.3240.726
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0520.94
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.60.506
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.4460.0408
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CORIN in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.82.712.10.0439
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.83.411.40.0746
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.55.93.61
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.49.16.31
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382718.418.5-0.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221322.715.47.30.689
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161412.521.4-8.90.642
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCORIN
Namecorin, serine peptidase
Aliases PRSC; ATC2; TMPRSS10; corin, serine protease; PEE5; heart-specific serine proteinase ATC2; pro-ANP-convertas ......
Chromosomal Location4p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CORIN. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCORIN
Namecorin, serine peptidase
Aliases PRSC; ATC2; TMPRSS10; corin, serine protease; PEE5; heart-specific serine proteinase ATC2; pro-ANP-convertas ......
Chromosomal Location4p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CORIN. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CORIN.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCORIN
Namecorin, serine peptidase
Aliases PRSC; ATC2; TMPRSS10; corin, serine protease; PEE5; heart-specific serine proteinase ATC2; pro-ANP-convertas ......
Chromosomal Location4p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CORIN. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCORIN
Namecorin, serine peptidase
Aliases PRSC; ATC2; TMPRSS10; corin, serine protease; PEE5; heart-specific serine proteinase ATC2; pro-ANP-convertas ......
Chromosomal Location4p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CORIN expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCORIN
Namecorin, serine peptidase
Aliases PRSC; ATC2; TMPRSS10; corin, serine protease; PEE5; heart-specific serine proteinase ATC2; pro-ANP-convertas ......
Chromosomal Location4p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CORIN and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCORIN
Namecorin, serine peptidase
Aliases PRSC; ATC2; TMPRSS10; corin, serine protease; PEE5; heart-specific serine proteinase ATC2; pro-ANP-convertas ......
Chromosomal Location4p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CORIN collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.