TISIDB

Summary
Symbol	CRLF1
Name	cytokine receptor-like factor 1
Aliases	CLF-1; CISS; CISS1; cold-induced sweating syndrome; zcytor5; cytokine type 1 receptor CRLP-1; cytokine-like ......
Chromosomal Location	19p12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Secreted
Domain	PF09067 Erythropoietin receptor PF00041 Fibronectin type III domain
Function	Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development.

> Gene Ontology [ TOP ]
Biological Process	GO:0001655 urogenital system development GO:0001657 ureteric bud development GO:0001822 kidney development GO:0001823 mesonephros development GO:0007259 JAK-STAT cascade GO:0007260 tyrosine phosphorylation of STAT protein GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0042503 tyrosine phosphorylation of Stat3 protein GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO:0042516 regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0043523 regulation of neuron apoptotic process GO:0043524 negative regulation of neuron apoptotic process GO:0046425 regulation of JAK-STAT cascade GO:0046427 positive regulation of JAK-STAT cascade GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0051402 neuron apoptotic process GO:0070997 neuron death GO:0072001 renal system development GO:0072073 kidney epithelium development GO:0072163 mesonephric epithelium development GO:0072164 mesonephric tubule development GO:0097049 motor neuron apoptotic process GO:0097696 STAT cascade GO:1901214 regulation of neuron death GO:1901215 negative regulation of neuron death GO:1904892 regulation of STAT cascade GO:1904894 positive regulation of STAT cascade GO:2000671 regulation of motor neuron apoptotic process GO:2000672 negative regulation of motor neuron apoptotic process
Molecular Function	GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0005127 ciliary neurotrophic factor receptor binding GO:0019955 cytokine binding GO:0046982 protein heterodimerization activity
Cellular Component	GO:0097058 CRLF-CLCF1 complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-6788467: IL-6-type cytokine receptor ligand interactions R-HSA-168256: Immune System R-HSA-6783589: Interleukin-6 family signaling R-HSA-449147: Signaling by Interleukins

Summary
Symbol	CRLF1
Name	cytokine receptor-like factor 1
Aliases	CLF-1; CISS; CISS1; cold-induced sweating syndrome; zcytor5; cytokine type 1 receptor CRLP-1; cytokine-like ......
Chromosomal Location	19p12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between CRLF1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	CRLF1
Name	cytokine receptor-like factor 1
Aliases	CLF-1; CISS; CISS1; cold-induced sweating syndrome; zcytor5; cytokine type 1 receptor CRLP-1; cytokine-like ......
Chromosomal Location	19p12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of CRLF1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	CRLF1
Name	cytokine receptor-like factor 1
Aliases	CLF-1; CISS; CISS1; cold-induced sweating syndrome; zcytor5; cytokine type 1 receptor CRLP-1; cytokine-like ......
Chromosomal Location	19p12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of CRLF1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-1.557	0.00168
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-3.172	1.44e-05
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.389	0.619
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.267	0.463
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.478	0.715
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.003	0.999
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.76	0.236
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.403	0.669
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-1.047	0.31
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.628	0.624
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.564	0.339
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-1.014	0.000903

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of CRLF1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	5.9	-5.9	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	7.1	-7.1	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	0	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	0	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	12.5	-12.5	0.52
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	14.3	-14.3	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	1

Summary
Symbol	CRLF1
Name	cytokine receptor-like factor 1
Aliases	CLF-1; CISS; CISS1; cold-induced sweating syndrome; zcytor5; cytokine type 1 receptor CRLP-1; cytokine-like ......
Chromosomal Location	19p12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CRLF1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	CRLF1
Name	cytokine receptor-like factor 1
Aliases	CLF-1; CISS; CISS1; cold-induced sweating syndrome; zcytor5; cytokine type 1 receptor CRLP-1; cytokine-like ......
Chromosomal Location	19p12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CRLF1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CRLF1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	CRLF1
Name	cytokine receptor-like factor 1
Aliases	CLF-1; CISS; CISS1; cold-induced sweating syndrome; zcytor5; cytokine type 1 receptor CRLP-1; cytokine-like ......
Chromosomal Location	19p12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CRLF1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	CRLF1
Name	cytokine receptor-like factor 1
Aliases	CLF-1; CISS; CISS1; cold-induced sweating syndrome; zcytor5; cytokine type 1 receptor CRLP-1; cytokine-like ......
Chromosomal Location	19p12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of CRLF1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	CRLF1
Name	cytokine receptor-like factor 1
Aliases	CLF-1; CISS; CISS1; cold-induced sweating syndrome; zcytor5; cytokine type 1 receptor CRLP-1; cytokine-like ......
Chromosomal Location	19p12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between CRLF1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	CRLF1
Name	cytokine receptor-like factor 1
Aliases	CLF-1; CISS; CISS1; cold-induced sweating syndrome; zcytor5; cytokine type 1 receptor CRLP-1; cytokine-like ......
Chromosomal Location	19p12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting CRLF1 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse CRLF1