Browse CRYAB

Summary
SymbolCRYAB
Namecrystallin, alpha B
Aliases HSPB5; CRYA2; CMD1II; CTPP2; CTRCT16; HEL-S-101; MFM2; epididymis secretory protein Li 101; heat shock prote ......
Chromosomal Location11q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Nucleus Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles (PubMed:19464326). Localizes at the Z-bands and the intercalated disk in cardiomyocytes (PubMed:28493373).
Domain PF00525 Alpha crystallin A chain
PF00011 Hsp20/alpha crystallin family
Function

May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.

> Gene Ontology
 
Biological Process GO:0000226 microtubule cytoskeleton organization
GO:0000302 response to reactive oxygen species
GO:0001558 regulation of cell growth
GO:0001654 eye development
GO:0001666 response to hypoxia
GO:0002088 lens development in camera-type eye
GO:0003012 muscle system process
GO:0006457 protein folding
GO:0006936 muscle contraction
GO:0006979 response to oxidative stress
GO:0007021 tubulin complex assembly
GO:0007423 sensory organ development
GO:0007517 muscle organ development
GO:0007568 aging
GO:0009266 response to temperature stimulus
GO:0009314 response to radiation
GO:0009408 response to heat
GO:0010035 response to inorganic substance
GO:0010212 response to ionizing radiation
GO:0010332 response to gamma radiation
GO:0010466 negative regulation of peptidase activity
GO:0010951 negative regulation of endopeptidase activity
GO:0016049 cell growth
GO:0030308 negative regulation of cell growth
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031109 microtubule polymerization or depolymerization
GO:0032355 response to estradiol
GO:0032386 regulation of intracellular transport
GO:0032387 negative regulation of intracellular transport
GO:0034605 cellular response to heat
GO:0036293 response to decreased oxygen levels
GO:0042542 response to hydrogen peroxide
GO:0043010 camera-type eye development
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045861 negative regulation of proteolysis
GO:0045926 negative regulation of growth
GO:0051051 negative regulation of transport
GO:0051259 protein oligomerization
GO:0051260 protein homooligomerization
GO:0051346 negative regulation of hydrolase activity
GO:0051403 stress-activated MAPK cascade
GO:0052547 regulation of peptidase activity
GO:0052548 regulation of endopeptidase activity
GO:0060561 apoptotic process involved in morphogenesis
GO:0070482 response to oxygen levels
GO:0071214 cellular response to abiotic stimulus
GO:0071478 cellular response to radiation
GO:0071479 cellular response to ionizing radiation
GO:0071480 cellular response to gamma radiation
GO:0072593 reactive oxygen species metabolic process
GO:1900034 regulation of cellular response to heat
GO:1902742 apoptotic process involved in development
GO:2000116 regulation of cysteine-type endopeptidase activity
GO:2000117 negative regulation of cysteine-type endopeptidase activity
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000378 negative regulation of reactive oxygen species metabolic process
Molecular Function GO:0005212 structural constituent of eye lens
GO:0008017 microtubule binding
GO:0015631 tubulin binding
GO:0051082 unfolded protein binding
Cellular Component GO:0014069 postsynaptic density
GO:0015629 actin cytoskeleton
GO:0030016 myofibril
GO:0030017 sarcomere
GO:0030018 Z disc
GO:0030424 axon
GO:0030425 dendrite
GO:0031430 M band
GO:0031672 A band
GO:0031674 I band
GO:0032432 actin filament bundle
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0043204 perikaryon
GO:0043209 myelin sheath
GO:0043292 contractile fiber
GO:0044297 cell body
GO:0044309 neuron spine
GO:0044449 contractile fiber part
GO:0060076 excitatory synapse
GO:0097060 synaptic membrane
GO:0097512 cardiac myofibril
GO:0098794 postsynapse
GO:0099572 postsynaptic specialization
> KEGG and Reactome Pathway
 
KEGG hsa04141 Protein processing in endoplasmic reticulum
Reactome -
Summary
SymbolCRYAB
Namecrystallin, alpha B
Aliases HSPB5; CRYA2; CMD1II; CTPP2; CTRCT16; HEL-S-101; MFM2; epididymis secretory protein Li 101; heat shock prote ......
Chromosomal Location11q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CRYAB and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolCRYAB
Namecrystallin, alpha B
Aliases HSPB5; CRYA2; CMD1II; CTPP2; CTRCT16; HEL-S-101; MFM2; epididymis secretory protein Li 101; heat shock prote ......
Chromosomal Location11q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CRYAB in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCRYAB
Namecrystallin, alpha B
Aliases HSPB5; CRYA2; CMD1II; CTPP2; CTRCT16; HEL-S-101; MFM2; epididymis secretory protein Li 101; heat shock prote ......
Chromosomal Location11q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CRYAB in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14122.1560.00609
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)652.4790.49
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)871.920.474
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.6190.392
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2350.914
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.1030.687
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.4790.506
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.3840.844
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.5290.799
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.3450.918
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.5370.915
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.6380.00161
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CRYAB in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCRYAB
Namecrystallin, alpha B
Aliases HSPB5; CRYA2; CMD1II; CTPP2; CTRCT16; HEL-S-101; MFM2; epididymis secretory protein Li 101; heat shock prote ......
Chromosomal Location11q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CRYAB. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCRYAB
Namecrystallin, alpha B
Aliases HSPB5; CRYA2; CMD1II; CTPP2; CTRCT16; HEL-S-101; MFM2; epididymis secretory protein Li 101; heat shock prote ......
Chromosomal Location11q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CRYAB. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CRYAB.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCRYAB
Namecrystallin, alpha B
Aliases HSPB5; CRYA2; CMD1II; CTPP2; CTRCT16; HEL-S-101; MFM2; epididymis secretory protein Li 101; heat shock prote ......
Chromosomal Location11q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CRYAB. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCRYAB
Namecrystallin, alpha B
Aliases HSPB5; CRYA2; CMD1II; CTPP2; CTRCT16; HEL-S-101; MFM2; epididymis secretory protein Li 101; heat shock prote ......
Chromosomal Location11q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CRYAB expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCRYAB
Namecrystallin, alpha B
Aliases HSPB5; CRYA2; CMD1II; CTPP2; CTRCT16; HEL-S-101; MFM2; epididymis secretory protein Li 101; heat shock prote ......
Chromosomal Location11q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CRYAB and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCRYAB
Namecrystallin, alpha B
Aliases HSPB5; CRYA2; CMD1II; CTPP2; CTRCT16; HEL-S-101; MFM2; epididymis secretory protein Li 101; heat shock prote ......
Chromosomal Location11q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CRYAB collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.