Browse CSF1

Summary
SymbolCSF1
Namecolony stimulating factor 1 (macrophage)
Aliases M-CSF; MCSF; MGC31930; CSF-1; lanimostim; Macrophage colony-stimulating factor 1
Chromosomal Location1p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Single-pass type I membrane protein ; SUBCELLULAR LOCATION: Processed macrophage colony-stimulating factor 1: Secreted, extracellular space.
Domain PF05337 Macrophage colony stimulating factor-1 (CSF-1)
Function

Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.

> Gene Ontology
 
Biological Process GO:0001503 ossification
GO:0001763 morphogenesis of a branching structure
GO:0001894 tissue homeostasis
GO:0001952 regulation of cell-matrix adhesion
GO:0001954 positive regulation of cell-matrix adhesion
GO:0001959 regulation of cytokine-mediated signaling pathway
GO:0001961 positive regulation of cytokine-mediated signaling pathway
GO:0002158 osteoclast proliferation
GO:0002274 myeloid leukocyte activation
GO:0002521 leukocyte differentiation
GO:0002573 myeloid leukocyte differentiation
GO:0002685 regulation of leukocyte migration
GO:0002687 positive regulation of leukocyte migration
GO:0002688 regulation of leukocyte chemotaxis
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0002761 regulation of myeloid leukocyte differentiation
GO:0002763 positive regulation of myeloid leukocyte differentiation
GO:0007160 cell-matrix adhesion
GO:0007265 Ras protein signal transduction
GO:0008347 glial cell migration
GO:0010720 positive regulation of cell development
GO:0010742 macrophage derived foam cell differentiation
GO:0010743 regulation of macrophage derived foam cell differentiation
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0010758 regulation of macrophage chemotaxis
GO:0010759 positive regulation of macrophage chemotaxis
GO:0010810 regulation of cell-substrate adhesion
GO:0010811 positive regulation of cell-substrate adhesion
GO:0014013 regulation of gliogenesis
GO:0014015 positive regulation of gliogenesis
GO:0022612 gland morphogenesis
GO:0030099 myeloid cell differentiation
GO:0030224 monocyte differentiation
GO:0030225 macrophage differentiation
GO:0030278 regulation of ossification
GO:0030316 osteoclast differentiation
GO:0030335 positive regulation of cell migration
GO:0030595 leukocyte chemotaxis
GO:0030879 mammary gland development
GO:0031589 cell-substrate adhesion
GO:0032103 positive regulation of response to external stimulus
GO:0032943 mononuclear cell proliferation
GO:0032944 regulation of mononuclear cell proliferation
GO:0032946 positive regulation of mononuclear cell proliferation
GO:0033674 positive regulation of kinase activity
GO:0035239 tube morphogenesis
GO:0035264 multicellular organism growth
GO:0036005 response to macrophage colony-stimulating factor
GO:0036006 cellular response to macrophage colony-stimulating factor stimulus
GO:0038145 macrophage colony-stimulating factor signaling pathway
GO:0040014 regulation of multicellular organism growth
GO:0040017 positive regulation of locomotion
GO:0040018 positive regulation of multicellular organism growth
GO:0042063 gliogenesis
GO:0042117 monocyte activation
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042476 odontogenesis
GO:0042481 regulation of odontogenesis
GO:0042482 positive regulation of odontogenesis
GO:0042487 regulation of odontogenesis of dentin-containing tooth
GO:0042488 positive regulation of odontogenesis of dentin-containing tooth
GO:0045637 regulation of myeloid cell differentiation
GO:0045639 positive regulation of myeloid cell differentiation
GO:0045649 regulation of macrophage differentiation
GO:0045651 positive regulation of macrophage differentiation
GO:0045655 regulation of monocyte differentiation
GO:0045657 positive regulation of monocyte differentiation
GO:0045670 regulation of osteoclast differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0045785 positive regulation of cell adhesion
GO:0045860 positive regulation of protein kinase activity
GO:0045927 positive regulation of growth
GO:0046578 regulation of Ras protein signal transduction
GO:0046579 positive regulation of Ras protein signal transduction
GO:0048246 macrophage chemotaxis
GO:0048638 regulation of developmental growth
GO:0048639 positive regulation of developmental growth
GO:0048732 gland development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048871 multicellular organismal homeostasis
GO:0048872 homeostasis of number of cells
GO:0048873 homeostasis of number of cells within a tissue
GO:0050769 positive regulation of neurogenesis
GO:0050900 leukocyte migration
GO:0050920 regulation of chemotaxis
GO:0050921 positive regulation of chemotaxis
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051057 positive regulation of small GTPase mediated signal transduction
GO:0051272 positive regulation of cellular component movement
GO:0051962 positive regulation of nervous system development
GO:0060249 anatomical structure homeostasis
GO:0060326 cell chemotaxis
GO:0060443 mammary gland morphogenesis
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0060560 developmental growth involved in morphogenesis
GO:0060562 epithelial tube morphogenesis
GO:0060603 mammary gland duct morphogenesis
GO:0060611 mammary gland fat development
GO:0060612 adipose tissue development
GO:0060759 regulation of response to cytokine stimulus
GO:0060760 positive regulation of response to cytokine stimulus
GO:0060763 mammary duct terminal end bud growth
GO:0061138 morphogenesis of a branching epithelium
GO:0061180 mammary gland epithelium development
GO:0061448 connective tissue development
GO:0070661 leukocyte proliferation
GO:0070663 regulation of leukocyte proliferation
GO:0070665 positive regulation of leukocyte proliferation
GO:0071621 granulocyte chemotaxis
GO:0071622 regulation of granulocyte chemotaxis
GO:0071674 mononuclear cell migration
GO:0071675 regulation of mononuclear cell migration
GO:0090077 foam cell differentiation
GO:0097529 myeloid leukocyte migration
GO:0097530 granulocyte migration
GO:1902105 regulation of leukocyte differentiation
GO:1902107 positive regulation of leukocyte differentiation
GO:1902226 regulation of macrophage colony-stimulating factor signaling pathway
GO:1902228 positive regulation of macrophage colony-stimulating factor signaling pathway
GO:1903131 mononuclear cell differentiation
GO:1903706 regulation of hemopoiesis
GO:1903708 positive regulation of hemopoiesis
GO:1903969 regulation of response to macrophage colony-stimulating factor
GO:1903971 positive regulation of response to macrophage colony-stimulating factor
GO:1903972 regulation of cellular response to macrophage colony-stimulating factor stimulus
GO:1903974 positive regulation of cellular response to macrophage colony-stimulating factor stimulus
GO:1903975 regulation of glial cell migration
GO:1903977 positive regulation of glial cell migration
GO:1904124 microglial cell migration
GO:1904139 regulation of microglial cell migration
GO:1904141 positive regulation of microglial cell migration
GO:2000027 regulation of organ morphogenesis
GO:2000147 positive regulation of cell motility
Molecular Function GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005157 macrophage colony-stimulating factor receptor binding
GO:0008083 growth factor activity
Cellular Component GO:1990682 CSF1-CSF1R complex
> KEGG and Reactome Pathway
 
KEGG hsa04014 Ras signaling pathway
hsa04015 Rap1 signaling pathway
hsa04060 Cytokine-cytokine receptor interaction
hsa04151 PI3K-Akt signaling pathway
hsa04380 Osteoclast differentiation
hsa04640 Hematopoietic cell lineage
hsa04668 TNF signaling pathway
Reactome R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-168256: Immune System
R-HSA-6783783: Interleukin-10 signaling
R-HSA-449147: Signaling by Interleukins
Summary
SymbolCSF1
Namecolony stimulating factor 1 (macrophage)
Aliases M-CSF; MCSF; MGC31930; CSF-1; lanimostim; Macrophage colony-stimulating factor 1
Chromosomal Location1p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CSF1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between CSF1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
27267143Diffuse-type tenosynovial giant cell tumourInhibit immunityThe finding that D-TGCT cells overexpress colony-stimulating factor 1 (CSF1), resulting in recruitment of CSF1 receptor (CSF1R)-bearing macrophages that are polyclonal and make up the bulk of the tumour, has led to clinical trials with CSF1R inhibitors.
23514705Pancreatic CarcinomaInhibit immunity (T cell function)Luminex analysis indicated that PSC but not human fetal primary pancreatic fibroblast cells (HPF; negative controls) produced MDSC-promoting cytokines [interleukin (IL-6), VEGF, macrophage colony-stimulating factor (M-CSF) ] and chemokines (SDF-1, MCP-1).
23418320Prostate CarcinomaInhibit immunity (infiltration)Enhanced macrophage migration induced by conditioned media from irradiated tumor cells was completely blocked by a selective inhibitor of CSF1R. These findings were confirmed in patients with prostate cancer, where serum levels of CSF1 increased after radiotherapy.
24796276Breast CarcinomaInhibit immunityHere, we report that intense local proliferation of fully differentiated macrophages rather than low-pace recruitment of blood-borne precursors drives TAM accumulation in a mouse model of spontaneous mammary carcinogenesis, the MMTVneu strain. TAM differentiation and expansion is regulated by CSF1, whose expression is directly controlled by STAT1 at the gene promoter level. These findings appear to be also relevant for human breast cancer, in which an interrelationship between STAT1, CSF1, and macrophage marker expression was identified.
25082815pancreatic carcinomaInhibit immunityCSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models
Summary
SymbolCSF1
Namecolony stimulating factor 1 (macrophage)
Aliases M-CSF; MCSF; MGC31930; CSF-1; lanimostim; Macrophage colony-stimulating factor 1
Chromosomal Location1p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CSF1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCSF1
Namecolony stimulating factor 1 (macrophage)
Aliases M-CSF; MCSF; MGC31930; CSF-1; lanimostim; Macrophage colony-stimulating factor 1
Chromosomal Location1p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CSF1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.370.388
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.7170.698
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.120.933
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.410.336
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.9420.621
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2630.914
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.030.941
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.2840.847
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.3660.82
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.4810.341
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 282.2510.316
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2770.045
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CSF1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCSF1
Namecolony stimulating factor 1 (macrophage)
Aliases M-CSF; MCSF; MGC31930; CSF-1; lanimostim; Macrophage colony-stimulating factor 1
Chromosomal Location1p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CSF1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCSF1
Namecolony stimulating factor 1 (macrophage)
Aliases M-CSF; MCSF; MGC31930; CSF-1; lanimostim; Macrophage colony-stimulating factor 1
Chromosomal Location1p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CSF1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CSF1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCSF1
Namecolony stimulating factor 1 (macrophage)
Aliases M-CSF; MCSF; MGC31930; CSF-1; lanimostim; Macrophage colony-stimulating factor 1
Chromosomal Location1p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CSF1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCSF1
Namecolony stimulating factor 1 (macrophage)
Aliases M-CSF; MCSF; MGC31930; CSF-1; lanimostim; Macrophage colony-stimulating factor 1
Chromosomal Location1p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CSF1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCSF1
Namecolony stimulating factor 1 (macrophage)
Aliases M-CSF; MCSF; MGC31930; CSF-1; lanimostim; Macrophage colony-stimulating factor 1
Chromosomal Location1p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CSF1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCSF1
Namecolony stimulating factor 1 (macrophage)
Aliases M-CSF; MCSF; MGC31930; CSF-1; lanimostim; Macrophage colony-stimulating factor 1
Chromosomal Location1p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CSF1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.