Browse CSF3

Summary
SymbolCSF3
Namecolony stimulating factor 3 (granulocyte)
Aliases MGC45931; granulocyte colony stimulating factor; pluripoietin; filgrastim; lenograstim; GCSF; G-CSF; C17orf3 ......
Chromosomal Location17q11.2-q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted.
Domain PF16647 Granulocyte colony-stimulating factor
Function

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.

> Gene Ontology
 
Biological Process GO:0002237 response to molecule of bacterial origin
GO:0002521 leukocyte differentiation
GO:0002573 myeloid leukocyte differentiation
GO:0006606 protein import into nucleus
GO:0006913 nucleocytoplasmic transport
GO:0007015 actin filament organization
GO:0008064 regulation of actin polymerization or depolymerization
GO:0008154 actin polymerization or depolymerization
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0017038 protein import
GO:0018105 peptidyl-serine phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018209 peptidyl-serine modification
GO:0018212 peptidyl-tyrosine modification
GO:0030041 actin filament polymerization
GO:0030099 myeloid cell differentiation
GO:0030832 regulation of actin filament length
GO:0030833 regulation of actin filament polymerization
GO:0030838 positive regulation of actin filament polymerization
GO:0030851 granulocyte differentiation
GO:0031334 positive regulation of protein complex assembly
GO:0031532 actin cytoskeleton reorganization
GO:0032092 positive regulation of protein binding
GO:0032271 regulation of protein polymerization
GO:0032273 positive regulation of protein polymerization
GO:0032386 regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0032496 response to lipopolysaccharide
GO:0032535 regulation of cellular component size
GO:0032956 regulation of actin cytoskeleton organization
GO:0032970 regulation of actin filament-based process
GO:0033135 regulation of peptidyl-serine phosphorylation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033157 regulation of intracellular protein transport
GO:0034504 protein localization to nucleus
GO:0042306 regulation of protein import into nucleus
GO:0042307 positive regulation of protein import into nucleus
GO:0042990 regulation of transcription factor import into nucleus
GO:0042991 transcription factor import into nucleus
GO:0042993 positive regulation of transcription factor import into nucleus
GO:0043254 regulation of protein complex assembly
GO:0043393 regulation of protein binding
GO:0043491 protein kinase B signaling
GO:0044089 positive regulation of cellular component biogenesis
GO:0044744 protein targeting to nucleus
GO:0045471 response to ethanol
GO:0045637 regulation of myeloid cell differentiation
GO:0045639 positive regulation of myeloid cell differentiation
GO:0046822 regulation of nucleocytoplasmic transport
GO:0046824 positive regulation of nucleocytoplasmic transport
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048017 inositol lipid-mediated signaling
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051098 regulation of binding
GO:0051099 positive regulation of binding
GO:0051169 nuclear transport
GO:0051170 nuclear import
GO:0051222 positive regulation of protein transport
GO:0051258 protein polymerization
GO:0051493 regulation of cytoskeleton organization
GO:0051495 positive regulation of cytoskeleton organization
GO:0051896 regulation of protein kinase B signaling
GO:0051897 positive regulation of protein kinase B signaling
GO:0070997 neuron death
GO:0071216 cellular response to biotic stimulus
GO:0071219 cellular response to molecule of bacterial origin
GO:0071222 cellular response to lipopolysaccharide
GO:0071396 cellular response to lipid
GO:0090066 regulation of anatomical structure size
GO:0090316 positive regulation of intracellular protein transport
GO:0097305 response to alcohol
GO:1900180 regulation of protein localization to nucleus
GO:1900182 positive regulation of protein localization to nucleus
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1902593 single-organism nuclear import
GO:1903533 regulation of protein targeting
GO:1903706 regulation of hemopoiesis
GO:1903708 positive regulation of hemopoiesis
GO:1903829 positive regulation of cellular protein localization
GO:1904589 regulation of protein import
GO:1904591 positive regulation of protein import
GO:1904951 positive regulation of establishment of protein localization
GO:2000249 regulation of actin cytoskeleton reorganization
GO:2000251 positive regulation of actin cytoskeleton reorganization
Molecular Function GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005130 granulocyte colony-stimulating factor receptor binding
GO:0008083 growth factor activity
GO:0070851 growth factor receptor binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04060 Cytokine-cytokine receptor interaction
hsa04151 PI3K-Akt signaling pathway
hsa04630 Jak-STAT signaling pathway
hsa04640 Hematopoietic cell lineage
Reactome R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-168256: Immune System
R-HSA-6783783: Interleukin-10 signaling
R-HSA-449147: Signaling by Interleukins
Summary
SymbolCSF3
Namecolony stimulating factor 3 (granulocyte)
Aliases MGC45931; granulocyte colony stimulating factor; pluripoietin; filgrastim; lenograstim; GCSF; G-CSF; C17orf3 ......
Chromosomal Location17q11.2-q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CSF3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between CSF3 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
25624500Breast CarcinomaInhibit immunityThese results demonstrate that prolonged G-CSF may be responsible for both the development and activity of immunosuppressive neutrophils in cancer.
21480223Bladder CarcinomaInhibit immunityBoth myeloid cell subsets from cancer patients were highly activated and produced substantial amounts of proinflammatory chemokines/cytokines including CCL2, CCL3, CCL4, G-CSF, IL-8 and IL-6. We demonstrate that these highly activated inflammatory myeloid cells represent a source of multiple chemokines/cytokines and may contribute to inflammation and immune dysfunction in bladder cancer.
29805099Triple-Negative Breast CarcinomaInhibit immunityIn two TNBC mouse models, 4T1 and Py8119, glycolysis restriction inhibits tumor granulocyte colony-stimulating factor (G-CSF) and granulocyte macrophage colony-stimulating factor (GM-CSF) expression and reduces MDSCs. These are accompanied with enhanced T cell immunity, reduced tumor growth and metastasis, and prolonged mouse survival.
Summary
SymbolCSF3
Namecolony stimulating factor 3 (granulocyte)
Aliases MGC45931; granulocyte colony stimulating factor; pluripoietin; filgrastim; lenograstim; GCSF; G-CSF; C17orf3 ......
Chromosomal Location17q11.2-q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CSF3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCSF3
Namecolony stimulating factor 3 (granulocyte)
Aliases MGC45931; granulocyte colony stimulating factor; pluripoietin; filgrastim; lenograstim; GCSF; G-CSF; C17orf3 ......
Chromosomal Location17q11.2-q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CSF3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2770.52
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0090.99
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.4930.444
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.9020.26
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-2.3010.0846
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.8710.607
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.5680.405
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.8690.624
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.2880.879
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 4801
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 2801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.4730.15
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolCSF3
Namecolony stimulating factor 3 (granulocyte)
Aliases MGC45931; granulocyte colony stimulating factor; pluripoietin; filgrastim; lenograstim; GCSF; G-CSF; C17orf3 ......
Chromosomal Location17q11.2-q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CSF3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCSF3
Namecolony stimulating factor 3 (granulocyte)
Aliases MGC45931; granulocyte colony stimulating factor; pluripoietin; filgrastim; lenograstim; GCSF; G-CSF; C17orf3 ......
Chromosomal Location17q11.2-q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CSF3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CSF3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCSF3
Namecolony stimulating factor 3 (granulocyte)
Aliases MGC45931; granulocyte colony stimulating factor; pluripoietin; filgrastim; lenograstim; GCSF; G-CSF; C17orf3 ......
Chromosomal Location17q11.2-q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CSF3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCSF3
Namecolony stimulating factor 3 (granulocyte)
Aliases MGC45931; granulocyte colony stimulating factor; pluripoietin; filgrastim; lenograstim; GCSF; G-CSF; C17orf3 ......
Chromosomal Location17q11.2-q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CSF3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCSF3
Namecolony stimulating factor 3 (granulocyte)
Aliases MGC45931; granulocyte colony stimulating factor; pluripoietin; filgrastim; lenograstim; GCSF; G-CSF; C17orf3 ......
Chromosomal Location17q11.2-q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CSF3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCSF3
Namecolony stimulating factor 3 (granulocyte)
Aliases MGC45931; granulocyte colony stimulating factor; pluripoietin; filgrastim; lenograstim; GCSF; G-CSF; C17orf3 ......
Chromosomal Location17q11.2-q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CSF3 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.