Browse CTGF

Summary
SymbolCTGF
Nameconnective tissue growth factor
Aliases IGFBP8; CCN2; HCS24; NOV2; CCN family member 2; IBP-8; IGF-binding protein 8; IGFBP-8; hypertrophic chondroc ......
Chromosomal Location6q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted, extracellular space, extracellular matrix Secreted
Domain PF00007 Cystine-knot domain
PF00219 Insulin-like growth factor binding protein
PF00090 Thrombospondin type 1 domain
PF00093 von Willebrand factor type C domain
Function

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.

> Gene Ontology
 
Biological Process GO:0001101 response to acid chemical
GO:0001501 skeletal system development
GO:0001502 cartilage condensation
GO:0001503 ossification
GO:0001525 angiogenesis
GO:0001558 regulation of cell growth
GO:0001894 tissue homeostasis
GO:0002062 chondrocyte differentiation
GO:0003012 muscle system process
GO:0003013 circulatory system process
GO:0003015 heart process
GO:0006352 DNA-templated transcription, initiation
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006816 calcium ion transport
GO:0006936 muscle contraction
GO:0006937 regulation of muscle contraction
GO:0006941 striated muscle contraction
GO:0006942 regulation of striated muscle contraction
GO:0007015 actin filament organization
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007254 JNK cascade
GO:0007568 aging
GO:0008015 blood circulation
GO:0008016 regulation of heart contraction
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008544 epidermis development
GO:0009743 response to carbohydrate
GO:0009746 response to hexose
GO:0009749 response to glucose
GO:0010712 regulation of collagen metabolic process
GO:0010714 positive regulation of collagen metabolic process
GO:0010950 positive regulation of endopeptidase activity
GO:0010952 positive regulation of peptidase activity
GO:0016049 cell growth
GO:0030038 contractile actin filament bundle assembly
GO:0030198 extracellular matrix organization
GO:0030323 respiratory tube development
GO:0030324 lung development
GO:0031032 actomyosin structure organization
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031589 cell-substrate adhesion
GO:0031960 response to corticosteroid
GO:0032231 regulation of actin filament bundle assembly
GO:0032233 positive regulation of actin filament bundle assembly
GO:0032330 regulation of chondrocyte differentiation
GO:0032355 response to estradiol
GO:0032872 regulation of stress-activated MAPK cascade
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0032956 regulation of actin cytoskeleton organization
GO:0032963 collagen metabolic process
GO:0032964 collagen biosynthetic process
GO:0032965 regulation of collagen biosynthetic process
GO:0032967 positive regulation of collagen biosynthetic process
GO:0032970 regulation of actin filament-based process
GO:0034059 response to anoxia
GO:0034284 response to monosaccharide
GO:0035988 chondrocyte proliferation
GO:0036293 response to decreased oxygen levels
GO:0043062 extracellular structure organization
GO:0043149 stress fiber assembly
GO:0043200 response to amino acid
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043410 positive regulation of MAPK cascade
GO:0043434 response to peptide hormone
GO:0044057 regulation of system process
GO:0044089 positive regulation of cellular component biogenesis
GO:0044236 multicellular organism metabolic process
GO:0044246 regulation of multicellular organismal metabolic process
GO:0044253 positive regulation of multicellular organismal metabolic process
GO:0044259 multicellular organismal macromolecule metabolic process
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0045023 G0 to G1 transition
GO:0045787 positive regulation of cell cycle
GO:0045823 positive regulation of heart contraction
GO:0045862 positive regulation of proteolysis
GO:0045933 positive regulation of muscle contraction
GO:0045989 positive regulation of striated muscle contraction
GO:0046328 regulation of JNK cascade
GO:0046330 positive regulation of JNK cascade
GO:0048514 blood vessel morphogenesis
GO:0048545 response to steroid hormone
GO:0048705 skeletal system morphogenesis
GO:0048871 multicellular organismal homeostasis
GO:0050865 regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0051017 actin filament bundle assembly
GO:0051216 cartilage development
GO:0051385 response to mineralocorticoid
GO:0051403 stress-activated MAPK cascade
GO:0051492 regulation of stress fiber assembly
GO:0051493 regulation of cytoskeleton organization
GO:0051495 positive regulation of cytoskeleton organization
GO:0051496 positive regulation of stress fiber assembly
GO:0052547 regulation of peptidase activity
GO:0052548 regulation of endopeptidase activity
GO:0055117 regulation of cardiac muscle contraction
GO:0060047 heart contraction
GO:0060048 cardiac muscle contraction
GO:0060249 anatomical structure homeostasis
GO:0060401 cytosolic calcium ion transport
GO:0060452 positive regulation of cardiac muscle contraction
GO:0060541 respiratory system development
GO:0061035 regulation of cartilage development
GO:0061448 connective tissue development
GO:0061572 actin filament bundle organization
GO:0070278 extracellular matrix constituent secretion
GO:0070302 regulation of stress-activated protein kinase signaling cascade
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade
GO:0070316 regulation of G0 to G1 transition
GO:0070318 positive regulation of G0 to G1 transition
GO:0070371 ERK1 and ERK2 cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070482 response to oxygen levels
GO:0070542 response to fatty acid
GO:0070838 divalent metal ion transport
GO:0071774 response to fibroblast growth factor
GO:0071897 DNA biosynthetic process
GO:0072511 divalent inorganic cation transport
GO:0072593 reactive oxygen species metabolic process
GO:0090068 positive regulation of cell cycle process
GO:0090257 regulation of muscle system process
GO:0098743 cell aggregation
GO:1901652 response to peptide
GO:1903522 regulation of blood circulation
GO:1903524 positive regulation of blood circulation
GO:2000116 regulation of cysteine-type endopeptidase activity
GO:2001056 positive regulation of cysteine-type endopeptidase activity
Molecular Function GO:0001968 fibronectin binding
GO:0005178 integrin binding
GO:0005520 insulin-like growth factor binding
GO:0005539 glycosaminoglycan binding
GO:0008022 protein C-terminus binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0019838 growth factor binding
GO:0050839 cell adhesion molecule binding
GO:1901681 sulfur compound binding
Cellular Component GO:0005578 proteinaceous extracellular matrix
GO:0005801 cis-Golgi network
GO:0005938 cell cortex
GO:0099568 cytoplasmic region
> KEGG and Reactome Pathway
 
KEGG hsa04390 Hippo signaling pathway
Reactome R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-1989781: PPARA activates gene expression
R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-2032785: YAP1- and WWTR1 (TAZ)-stimulated gene expression
Summary
SymbolCTGF
Nameconnective tissue growth factor
Aliases IGFBP8; CCN2; HCS24; NOV2; CCN family member 2; IBP-8; IGF-binding protein 8; IGFBP-8; hypertrophic chondroc ......
Chromosomal Location6q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CTGF and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between CTGF and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
29596890ovarian carcinoma; Pancreatic ductal adenocarcinoma; mesotheliomaPromote immunityThe anti-tumor effects of the CTGF/MSLN DNA vaccine combined with anti-CD40 Ab and toll-like receptor 3 ligand-poly(I:C) were validated in an MSLN-expressing model.
Summary
SymbolCTGF
Nameconnective tissue growth factor
Aliases IGFBP8; CCN2; HCS24; NOV2; CCN family member 2; IBP-8; IGF-binding protein 8; IGFBP-8; hypertrophic chondroc ......
Chromosomal Location6q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CTGF in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCTGF
Nameconnective tissue growth factor
Aliases IGFBP8; CCN2; HCS24; NOV2; CCN family member 2; IBP-8; IGF-binding protein 8; IGFBP-8; hypertrophic chondroc ......
Chromosomal Location6q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CTGF in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.7360.182
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.0240.686
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.5140.764
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.8780.275
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.8470.754
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.9160.791
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0850.89
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2290.897
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1030.957
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.7950.73
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 282.4650.42
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.4690.0543
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolCTGF
Nameconnective tissue growth factor
Aliases IGFBP8; CCN2; HCS24; NOV2; CCN family member 2; IBP-8; IGF-binding protein 8; IGFBP-8; hypertrophic chondroc ......
Chromosomal Location6q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CTGF. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCTGF
Nameconnective tissue growth factor
Aliases IGFBP8; CCN2; HCS24; NOV2; CCN family member 2; IBP-8; IGF-binding protein 8; IGFBP-8; hypertrophic chondroc ......
Chromosomal Location6q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CTGF. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CTGF.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCTGF
Nameconnective tissue growth factor
Aliases IGFBP8; CCN2; HCS24; NOV2; CCN family member 2; IBP-8; IGF-binding protein 8; IGFBP-8; hypertrophic chondroc ......
Chromosomal Location6q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CTGF. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCTGF
Nameconnective tissue growth factor
Aliases IGFBP8; CCN2; HCS24; NOV2; CCN family member 2; IBP-8; IGF-binding protein 8; IGFBP-8; hypertrophic chondroc ......
Chromosomal Location6q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CTGF expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCTGF
Nameconnective tissue growth factor
Aliases IGFBP8; CCN2; HCS24; NOV2; CCN family member 2; IBP-8; IGF-binding protein 8; IGFBP-8; hypertrophic chondroc ......
Chromosomal Location6q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CTGF and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCTGF
Nameconnective tissue growth factor
Aliases IGFBP8; CCN2; HCS24; NOV2; CCN family member 2; IBP-8; IGF-binding protein 8; IGFBP-8; hypertrophic chondroc ......
Chromosomal Location6q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CTGF collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.