Browse CTNNB1

Summary
SymbolCTNNB1
Namecatenin (cadherin-associated protein), beta 1, 88kDa
Aliases beta-catenin; armadillo; CTNNB; catenin (cadherin-associated protein), beta 1 (88kD); MRD19; Catenin beta-1
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Nucleus Cytoplasm, cytoskeleton Cell junction, adherens junction Cell junction Cell membrane Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cell junction, synapse Cytoplasm, cytoskeleton, cilium basal body Note=Colocalized with RAPGEF2 and TJP1 at cell-cell contacts (By similarity). Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 and MUC1 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization. The majority of beta-catenin is localized to the cell membrane. In interphase, colocalizes with CROCC between CEP250 puncta at the proximal end of centrioles, and this localization is dependent on CROCC and CEP250. In mitosis, when NEK2 activity increases, it localizes to centrosomes at spindle poles independent of CROCC. Colocalizes with CDK5 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Interaction with FAM53B promotes translocation to the nucleus (PubMed:25183871).
Domain PF00514 Armadillo/beta-catenin-like repeat
Function

Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity).

> Gene Ontology
 
Biological Process GO:0000226 microtubule cytoskeleton organization
GO:0000578 embryonic axis specification
GO:0000723 telomere maintenance
GO:0000819 sister chromatid segregation
GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001525 angiogenesis
GO:0001569 patterning of blood vessels
GO:0001570 vasculogenesis
GO:0001649 osteoblast differentiation
GO:0001654 eye development
GO:0001655 urogenital system development
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001701 in utero embryonic development
GO:0001702 gastrulation with mouth forming second
GO:0001704 formation of primary germ layer
GO:0001706 endoderm formation
GO:0001708 cell fate specification
GO:0001709 cell fate determination
GO:0001711 endodermal cell fate commitment
GO:0001759 organ induction
GO:0001763 morphogenesis of a branching structure
GO:0001764 neuron migration
GO:0001819 positive regulation of cytokine production
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0001837 epithelial to mesenchymal transition
GO:0001838 embryonic epithelial tube formation
GO:0001840 neural plate development
GO:0001885 endothelial cell development
GO:0001894 tissue homeostasis
GO:0001942 hair follicle development
GO:0002052 positive regulation of neuroblast proliferation
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002062 chondrocyte differentiation
GO:0002064 epithelial cell development
GO:0002088 lens development in camera-type eye
GO:0002089 lens morphogenesis in camera-type eye
GO:0002521 leukocyte differentiation
GO:0002573 myeloid leukocyte differentiation
GO:0002683 negative regulation of immune system process
GO:0002694 regulation of leukocyte activation
GO:0002761 regulation of myeloid leukocyte differentiation
GO:0002762 negative regulation of myeloid leukocyte differentiation
GO:0003002 regionalization
GO:0003007 heart morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003156 regulation of animal organ formation
GO:0003158 endothelium development
GO:0003159 morphogenesis of an endothelium
GO:0003263 cardioblast proliferation
GO:0003264 regulation of cardioblast proliferation
GO:0003266 regulation of secondary heart field cardioblast proliferation
GO:0003306 Wnt signaling pathway involved in heart development
GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0003338 metanephros morphogenesis
GO:0003339 regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0006029 proteoglycan metabolic process
GO:0006278 RNA-dependent DNA biosynthetic process
GO:0006338 chromatin remodeling
GO:0006352 DNA-templated transcription, initiation
GO:0006479 protein methylation
GO:0006606 protein import into nucleus
GO:0006790 sulfur compound metabolic process
GO:0006816 calcium ion transport
GO:0006913 nucleocytoplasmic transport
GO:0007004 telomere maintenance via telomerase
GO:0007059 chromosome segregation
GO:0007062 sister chromatid cohesion
GO:0007063 regulation of sister chromatid cohesion
GO:0007098 centrosome cycle
GO:0007159 leukocyte cell-cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007272 ensheathment of neurons
GO:0007281 germ cell development
GO:0007292 female gamete generation
GO:0007346 regulation of mitotic cell cycle
GO:0007369 gastrulation
GO:0007389 pattern specification process
GO:0007398 ectoderm development
GO:0007403 glial cell fate determination
GO:0007405 neuroblast proliferation
GO:0007423 sensory organ development
GO:0007440 foregut morphogenesis
GO:0007492 endoderm development
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0007548 sex differentiation
GO:0008213 protein alkylation
GO:0008347 glial cell migration
GO:0008366 axon ensheathment
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008544 epidermis development
GO:0009100 glycoprotein metabolic process
GO:0009101 glycoprotein biosynthetic process
GO:0009755 hormone-mediated signaling pathway
GO:0009794 regulation of mitotic cell cycle, embryonic
GO:0009798 axis specification
GO:0009799 specification of symmetry
GO:0009855 determination of bilateral symmetry
GO:0009880 embryonic pattern specification
GO:0009913 epidermal cell differentiation
GO:0009948 anterior/posterior axis specification
GO:0009950 dorsal/ventral axis specification
GO:0009952 anterior/posterior pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0009954 proximal/distal pattern formation
GO:0009994 oocyte differentiation
GO:0010001 glial cell differentiation
GO:0010092 specification of animal organ identity
GO:0010457 centriole-centriole cohesion
GO:0010463 mesenchymal cell proliferation
GO:0010464 regulation of mesenchymal cell proliferation
GO:0010498 proteasomal protein catabolic process
GO:0010559 regulation of glycoprotein biosynthetic process
GO:0010560 positive regulation of glycoprotein biosynthetic process
GO:0010717 regulation of epithelial to mesenchymal transition
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010720 positive regulation of cell development
GO:0010721 negative regulation of cell development
GO:0010833 telomere maintenance via telomere lengthening
GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process
GO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic process
GO:0010959 regulation of metal ion transport
GO:0014013 regulation of gliogenesis
GO:0014014 negative regulation of gliogenesis
GO:0014045 establishment of endothelial blood-brain barrier
GO:0014706 striated muscle tissue development
GO:0015012 heparan sulfate proteoglycan biosynthetic process
GO:0016055 Wnt signaling pathway
GO:0016202 regulation of striated muscle tissue development
GO:0016331 morphogenesis of embryonic epithelium
GO:0016570 histone modification
GO:0016571 histone methylation
GO:0016925 protein sumoylation
GO:0017038 protein import
GO:0018022 peptidyl-lysine methylation
GO:0018205 peptidyl-lysine modification
GO:0019827 stem cell population maintenance
GO:0021537 telencephalon development
GO:0021543 pallium development
GO:0021545 cranial nerve development
GO:0021675 nerve development
GO:0021700 developmental maturation
GO:0021781 glial cell fate commitment
GO:0021795 cerebral cortex cell migration
GO:0021799 cerebral cortex radially oriented cell migration
GO:0021801 cerebral cortex radial glia guided migration
GO:0021819 layer formation in cerebral cortex
GO:0021885 forebrain cell migration
GO:0021953 central nervous system neuron differentiation
GO:0021987 cerebral cortex development
GO:0022009 central nervous system vasculogenesis
GO:0022029 telencephalon cell migration
GO:0022030 telencephalon glial cell migration
GO:0022404 molting cycle process
GO:0022405 hair cycle process
GO:0022407 regulation of cell-cell adhesion
GO:0022412 cellular process involved in reproduction in multicellular organism
GO:0030098 lymphocyte differentiation
GO:0030099 myeloid cell differentiation
GO:0030166 proteoglycan biosynthetic process
GO:0030201 heparan sulfate proteoglycan metabolic process
GO:0030217 T cell differentiation
GO:0030278 regulation of ossification
GO:0030316 osteoclast differentiation
GO:0030323 respiratory tube development
GO:0030324 lung development
GO:0030326 embryonic limb morphogenesis
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030521 androgen receptor signaling pathway
GO:0030522 intracellular receptor signaling pathway
GO:0030539 male genitalia development
GO:0030850 prostate gland development
GO:0030856 regulation of epithelial cell differentiation
GO:0030857 negative regulation of epithelial cell differentiation
GO:0030858 positive regulation of epithelial cell differentiation
GO:0030900 forebrain development
GO:0030901 midbrain development
GO:0030902 hindbrain development
GO:0030997 regulation of centriole-centriole cohesion
GO:0031016 pancreas development
GO:0031023 microtubule organizing center organization
GO:0031056 regulation of histone modification
GO:0031058 positive regulation of histone modification
GO:0031060 regulation of histone methylation
GO:0031062 positive regulation of histone methylation
GO:0031069 hair follicle morphogenesis
GO:0031128 developmental induction
GO:0031334 positive regulation of protein complex assembly
GO:0031589 cell-substrate adhesion
GO:0031641 regulation of myelination
GO:0032200 telomere organization
GO:0032204 regulation of telomere maintenance
GO:0032206 positive regulation of telomere maintenance
GO:0032210 regulation of telomere maintenance via telomerase
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0032259 methylation
GO:0032330 regulation of chondrocyte differentiation
GO:0032331 negative regulation of chondrocyte differentiation
GO:0032355 response to estradiol
GO:0032479 regulation of type I interferon production
GO:0032481 positive regulation of type I interferon production
GO:0032606 type I interferon production
GO:0032844 regulation of homeostatic process
GO:0032846 positive regulation of homeostatic process
GO:0032886 regulation of microtubule-based process
GO:0032943 mononuclear cell proliferation
GO:0032944 regulation of mononuclear cell proliferation
GO:0032984 macromolecular complex disassembly
GO:0033002 muscle cell proliferation
GO:0033044 regulation of chromosome organization
GO:0033045 regulation of sister chromatid segregation
GO:0033077 T cell differentiation in thymus
GO:0033233 regulation of protein sumoylation
GO:0033234 negative regulation of protein sumoylation
GO:0034329 cell junction assembly
GO:0034330 cell junction organization
GO:0034332 adherens junction organization
GO:0034333 adherens junction assembly
GO:0034394 protein localization to cell surface
GO:0034504 protein localization to nucleus
GO:0034968 histone lysine methylation
GO:0035050 embryonic heart tube development
GO:0035107 appendage morphogenesis
GO:0035108 limb morphogenesis
GO:0035112 genitalia morphogenesis
GO:0035113 embryonic appendage morphogenesis
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0035136 forelimb morphogenesis
GO:0035137 hindlimb morphogenesis
GO:0035148 tube formation
GO:0035239 tube morphogenesis
GO:0035315 hair cell differentiation
GO:0035411 catenin import into nucleus
GO:0035561 regulation of chromatin binding
GO:0035567 non-canonical Wnt signaling pathway
GO:0035850 epithelial cell differentiation involved in kidney development
GO:0035987 endodermal cell differentiation
GO:0036022 limb joint morphogenesis
GO:0036023 embryonic skeletal limb joint morphogenesis
GO:0040019 positive regulation of embryonic development
GO:0040029 regulation of gene expression, epigenetic
GO:0040036 regulation of fibroblast growth factor receptor signaling pathway
GO:0042063 gliogenesis
GO:0042098 T cell proliferation
GO:0042110 T cell activation
GO:0042129 regulation of T cell proliferation
GO:0042303 molting cycle
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042476 odontogenesis
GO:0042493 response to drug
GO:0042552 myelination
GO:0042633 hair cycle
GO:0042692 muscle cell differentiation
GO:0042733 embryonic digit morphogenesis
GO:0042762 regulation of sulfur metabolic process
GO:0043010 camera-type eye development
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043241 protein complex disassembly
GO:0043254 regulation of protein complex assembly
GO:0043401 steroid hormone mediated signaling pathway
GO:0043410 positive regulation of MAPK cascade
GO:0043414 macromolecule methylation
GO:0043523 regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0043586 tongue development
GO:0043587 tongue morphogenesis
GO:0043588 skin development
GO:0044089 positive regulation of cellular component biogenesis
GO:0044272 sulfur compound biosynthetic process
GO:0044334 canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0044340 canonical Wnt signaling pathway involved in regulation of cell proliferation
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0044744 protein targeting to nucleus
GO:0045165 cell fate commitment
GO:0045216 cell-cell junction organization
GO:0045446 endothelial cell differentiation
GO:0045448 mitotic cell cycle, embryonic
GO:0045453 bone resorption
GO:0045601 regulation of endothelial cell differentiation
GO:0045603 positive regulation of endothelial cell differentiation
GO:0045637 regulation of myeloid cell differentiation
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045667 regulation of osteoblast differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045670 regulation of osteoclast differentiation
GO:0045671 negative regulation of osteoclast differentiation
GO:0045685 regulation of glial cell differentiation
GO:0045686 negative regulation of glial cell differentiation
GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway
GO:0045765 regulation of angiogenesis
GO:0045778 positive regulation of ossification
GO:0045786 negative regulation of cell cycle
GO:0045815 positive regulation of gene expression, epigenetic
GO:0045844 positive regulation of striated muscle tissue development
GO:0045930 negative regulation of mitotic cell cycle
GO:0045976 negative regulation of mitotic cell cycle, embryonic
GO:0045992 negative regulation of embryonic development
GO:0045995 regulation of embryonic development
GO:0046651 lymphocyte proliferation
GO:0046661 male sex differentiation
GO:0046849 bone remodeling
GO:0048096 chromatin-mediated maintenance of transcription
GO:0048144 fibroblast proliferation
GO:0048145 regulation of fibroblast proliferation
GO:0048262 determination of dorsal/ventral asymmetry
GO:0048263 determination of dorsal identity
GO:0048469 cell maturation
GO:0048477 oogenesis
GO:0048483 autonomic nervous system development
GO:0048485 sympathetic nervous system development
GO:0048489 synaptic vesicle transport
GO:0048514 blood vessel morphogenesis
GO:0048538 thymus development
GO:0048545 response to steroid hormone
GO:0048546 digestive tract morphogenesis
GO:0048562 embryonic organ morphogenesis
GO:0048565 digestive tract development
GO:0048568 embryonic organ development
GO:0048592 eye morphogenesis
GO:0048593 camera-type eye morphogenesis
GO:0048599 oocyte development
GO:0048608 reproductive structure development
GO:0048617 embryonic foregut morphogenesis
GO:0048634 regulation of muscle organ development
GO:0048636 positive regulation of muscle organ development
GO:0048641 regulation of skeletal muscle tissue development
GO:0048643 positive regulation of skeletal muscle tissue development
GO:0048645 animal organ formation
GO:0048659 smooth muscle cell proliferation
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048704 embryonic skeletal system morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
GO:0048709 oligodendrocyte differentiation
GO:0048713 regulation of oligodendrocyte differentiation
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0048730 epidermis morphogenesis
GO:0048732 gland development
GO:0048736 appendage development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048762 mesenchymal cell differentiation
GO:0048771 tissue remodeling
GO:0048806 genitalia development
GO:0048871 multicellular organismal homeostasis
GO:0050670 regulation of lymphocyte proliferation
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050768 negative regulation of neurogenesis
GO:0050769 positive regulation of neurogenesis
GO:0050808 synapse organization
GO:0050863 regulation of T cell activation
GO:0050865 regulation of cell activation
GO:0051052 regulation of DNA metabolic process
GO:0051054 positive regulation of DNA metabolic process
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051098 regulation of binding
GO:0051101 regulation of DNA binding
GO:0051145 smooth muscle cell differentiation
GO:0051147 regulation of muscle cell differentiation
GO:0051149 positive regulation of muscle cell differentiation
GO:0051169 nuclear transport
GO:0051170 nuclear import
GO:0051176 positive regulation of sulfur metabolic process
GO:0051216 cartilage development
GO:0051249 regulation of lymphocyte activation
GO:0051297 centrosome organization
GO:0051402 neuron apoptotic process
GO:0051493 regulation of cytoskeleton organization
GO:0051568 histone H3-K4 methylation
GO:0051569 regulation of histone H3-K4 methylation
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0051640 organelle localization
GO:0051648 vesicle localization
GO:0051650 establishment of vesicle localization
GO:0051656 establishment of organelle localization
GO:0051924 regulation of calcium ion transport
GO:0051961 negative regulation of nervous system development
GO:0051962 positive regulation of nervous system development
GO:0051972 regulation of telomerase activity
GO:0051973 positive regulation of telomerase activity
GO:0051983 regulation of chromosome segregation
GO:0055123 digestive system development
GO:0060066 oviduct development
GO:0060070 canonical Wnt signaling pathway
GO:0060173 limb development
GO:0060231 mesenchymal to epithelial transition
GO:0060249 anatomical structure homeostasis
GO:0060272 embryonic skeletal joint morphogenesis
GO:0060423 foregut regionalization
GO:0060424 lung field specification
GO:0060425 lung morphogenesis
GO:0060431 primary lung bud formation
GO:0060438 trachea development
GO:0060439 trachea morphogenesis
GO:0060440 trachea formation
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060479 lung cell differentiation
GO:0060484 lung-associated mesenchyme development
GO:0060485 mesenchyme development
GO:0060492 lung induction
GO:0060537 muscle tissue development
GO:0060538 skeletal muscle organ development
GO:0060541 respiratory system development
GO:0060562 epithelial tube morphogenesis
GO:0060571 morphogenesis of an epithelial fold
GO:0060572 morphogenesis of an epithelial bud
GO:0060675 ureteric bud morphogenesis
GO:0060688 regulation of morphogenesis of a branching structure
GO:0060742 epithelial cell differentiation involved in prostate gland development
GO:0060767 epithelial cell proliferation involved in prostate gland development
GO:0060768 regulation of epithelial cell proliferation involved in prostate gland development
GO:0060769 positive regulation of epithelial cell proliferation involved in prostate gland development
GO:0060788 ectodermal placode formation
GO:0060789 hair follicle placode formation
GO:0060795 cell fate commitment involved in formation of primary germ layer
GO:0060856 establishment of blood-brain barrier
GO:0060914 heart formation
GO:0060916 mesenchymal cell proliferation involved in lung development
GO:0060993 kidney morphogenesis
GO:0061005 cell differentiation involved in kidney development
GO:0061028 establishment of endothelial barrier
GO:0061035 regulation of cartilage development
GO:0061037 negative regulation of cartilage development
GO:0061046 regulation of branching involved in lung morphogenesis
GO:0061047 positive regulation of branching involved in lung morphogenesis
GO:0061138 morphogenesis of a branching epithelium
GO:0061154 endothelial tube morphogenesis
GO:0061196 fungiform papilla development
GO:0061197 fungiform papilla morphogenesis
GO:0061198 fungiform papilla formation
GO:0061311 cell surface receptor signaling pathway involved in heart development
GO:0061316 canonical Wnt signaling pathway involved in heart development
GO:0061323 cell proliferation involved in heart morphogenesis
GO:0061324 canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
GO:0061325 cell proliferation involved in outflow tract morphogenesis
GO:0061326 renal tubule development
GO:0061333 renal tubule morphogenesis
GO:0061351 neural precursor cell proliferation
GO:0061448 connective tissue development
GO:0061458 reproductive system development
GO:0061548 ganglion development
GO:0061549 sympathetic ganglion development
GO:0061550 cranial ganglion development
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0070509 calcium ion import
GO:0070601 centromeric sister chromatid cohesion
GO:0070602 regulation of centromeric sister chromatid cohesion
GO:0070661 leukocyte proliferation
GO:0070663 regulation of leukocyte proliferation
GO:0070838 divalent metal ion transport
GO:0070997 neuron death
GO:0071383 cellular response to steroid hormone stimulus
GO:0071396 cellular response to lipid
GO:0071407 cellular response to organic cyclic compound
GO:0071417 cellular response to organonitrogen compound
GO:0071542 dopaminergic neuron differentiation
GO:0071593 lymphocyte aggregation
GO:0071594 thymocyte aggregation
GO:0071680 response to indole-3-methanol
GO:0071681 cellular response to indole-3-methanol
GO:0071696 ectodermal placode development
GO:0071697 ectodermal placode morphogenesis
GO:0071774 response to fibroblast growth factor
GO:0071897 DNA biosynthetic process
GO:0072001 renal system development
GO:0072006 nephron development
GO:0072009 nephron epithelium development
GO:0072028 nephron morphogenesis
GO:0072033 renal vesicle formation
GO:0072053 renal inner medulla development
GO:0072054 renal outer medulla development
GO:0072073 kidney epithelium development
GO:0072077 renal vesicle morphogenesis
GO:0072078 nephron tubule morphogenesis
GO:0072079 nephron tubule formation
GO:0072080 nephron tubule development
GO:0072087 renal vesicle development
GO:0072088 nephron epithelium morphogenesis
GO:0072089 stem cell proliferation
GO:0072091 regulation of stem cell proliferation
GO:0072160 nephron tubule epithelial cell differentiation
GO:0072163 mesonephric epithelium development
GO:0072164 mesonephric tubule development
GO:0072171 mesonephric tubule morphogenesis
GO:0072175 epithelial tube formation
GO:0072182 regulation of nephron tubule epithelial cell differentiation
GO:0072202 cell differentiation involved in metanephros development
GO:0072210 metanephric nephron development
GO:0072215 regulation of metanephros development
GO:0072217 negative regulation of metanephros development
GO:0072273 metanephric nephron morphogenesis
GO:0072283 metanephric renal vesicle morphogenesis
GO:0072498 embryonic skeletal joint development
GO:0072511 divalent inorganic cation transport
GO:0090183 regulation of kidney development
GO:0090185 negative regulation of kidney development
GO:0090279 regulation of calcium ion import
GO:0090287 regulation of cellular response to growth factor stimulus
GO:0090596 sensory organ morphogenesis
GO:0097305 response to alcohol
GO:0097306 cellular response to alcohol
GO:0097479 synaptic vesicle localization
GO:0097480 establishment of synaptic vesicle localization
GO:0098727 maintenance of cell number
GO:0098773 skin epidermis development
GO:0098813 nuclear chromosome segregation
GO:0198738 cell-cell signaling by wnt
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1901342 regulation of vasculature development
GO:1901861 regulation of muscle tissue development
GO:1901863 positive regulation of muscle tissue development
GO:1901963 regulation of cell proliferation involved in outflow tract morphogenesis
GO:1902105 regulation of leukocyte differentiation
GO:1902106 negative regulation of leukocyte differentiation
GO:1902275 regulation of chromatin organization
GO:1902593 single-organism nuclear import
GO:1902692 regulation of neuroblast proliferation
GO:1902730 positive regulation of proteoglycan biosynthetic process
GO:1903018 regulation of glycoprotein metabolic process
GO:1903020 positive regulation of glycoprotein metabolic process
GO:1903037 regulation of leukocyte cell-cell adhesion
GO:1903320 regulation of protein modification by small protein conjugation or removal
GO:1903321 negative regulation of protein modification by small protein conjugation or removal
GO:1903706 regulation of hemopoiesis
GO:1903707 negative regulation of hemopoiesis
GO:1904356 regulation of telomere maintenance via telomere lengthening
GO:1904358 positive regulation of telomere maintenance via telomere lengthening
GO:1904499 regulation of chromatin-mediated maintenance of transcription
GO:1904501 positive regulation of chromatin-mediated maintenance of transcription
GO:1904793 regulation of euchromatin binding
GO:1904796 regulation of core promoter binding
GO:1904837 beta-catenin-TCF complex assembly
GO:1904886 beta-catenin destruction complex disassembly
GO:1904888 cranial skeletal system development
GO:1904948 midbrain dopaminergic neuron differentiation
GO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
GO:1904954 canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
GO:1905269 positive regulation of chromatin organization
GO:1905330 regulation of morphogenesis of an epithelium
GO:1905331 negative regulation of morphogenesis of an epithelium
GO:1905332 positive regulation of morphogenesis of an epithelium
GO:1990403 embryonic brain development
GO:1990791 dorsal root ganglion development
GO:2000008 regulation of protein localization to cell surface
GO:2000015 regulation of determination of dorsal identity
GO:2000017 positive regulation of determination of dorsal identity
GO:2000027 regulation of organ morphogenesis
GO:2000136 regulation of cell proliferation involved in heart morphogenesis
GO:2000142 regulation of DNA-templated transcription, initiation
GO:2000144 positive regulation of DNA-templated transcription, initiation
GO:2000177 regulation of neural precursor cell proliferation
GO:2000179 positive regulation of neural precursor cell proliferation
GO:2000241 regulation of reproductive process
GO:2000243 positive regulation of reproductive process
GO:2000278 regulation of DNA biosynthetic process
GO:2000573 positive regulation of DNA biosynthetic process
GO:2000648 positive regulation of stem cell proliferation
GO:2000677 regulation of transcription regulatory region DNA binding
GO:2000696 regulation of epithelial cell differentiation involved in kidney development
GO:2000697 negative regulation of epithelial cell differentiation involved in kidney development
GO:2000826 regulation of heart morphogenesis
GO:2001233 regulation of apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001252 positive regulation of chromosome organization
Molecular Function GO:0001085 RNA polymerase II transcription factor binding
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0019902 phosphatase binding
GO:0019903 protein phosphatase binding
GO:0030331 estrogen receptor binding
GO:0033613 activating transcription factor binding
GO:0035257 nuclear hormone receptor binding
GO:0035258 steroid hormone receptor binding
GO:0044325 ion channel binding
GO:0045294 alpha-catenin binding
GO:0045296 cadherin binding
GO:0046332 SMAD binding
GO:0050681 androgen receptor binding
GO:0050839 cell adhesion molecule binding
GO:0051427 hormone receptor binding
GO:0070411 I-SMAD binding
GO:0070491 repressing transcription factor binding
GO:0098631 protein binding involved in cell adhesion
GO:0098632 protein binding involved in cell-cell adhesion
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:1990188 euchromatin binding
Cellular Component GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0000791 euchromatin
GO:0000922 spindle pole
GO:0005667 transcription factor complex
GO:0005719 nuclear euchromatin
GO:0005813 centrosome
GO:0005819 spindle
GO:0005901 caveola
GO:0005902 microvillus
GO:0005913 cell-cell adherens junction
GO:0005916 fascia adherens
GO:0005923 bicellular tight junction
GO:0005924 cell-substrate adherens junction
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0014704 intercalated disc
GO:0016323 basolateral plasma membrane
GO:0016328 lateral plasma membrane
GO:0016342 catenin complex
GO:0016600 flotillin complex
GO:0019897 extrinsic component of plasma membrane
GO:0019898 extrinsic component of membrane
GO:0030016 myofibril
GO:0030017 sarcomere
GO:0030018 Z disc
GO:0030027 lamellipodium
GO:0030055 cell-substrate junction
GO:0030877 beta-catenin destruction complex
GO:0031252 cell leading edge
GO:0031253 cell projection membrane
GO:0031528 microvillus membrane
GO:0031674 I band
GO:0032993 protein-DNA complex
GO:0034750 Scrib-APC-beta-catenin complex
GO:0043292 contractile fiber
GO:0043296 apical junction complex
GO:0044291 cell-cell contact zone
GO:0044449 contractile fiber part
GO:0044454 nuclear chromosome part
GO:0044798 nuclear transcription factor complex
GO:0044853 plasma membrane raft
GO:0045121 membrane raft
GO:0045177 apical part of cell
GO:0070160 occluding junction
GO:0070369 beta-catenin-TCF7L2 complex
GO:0071664 catenin-TCF7L2 complex
GO:0090575 RNA polymerase II transcription factor complex
GO:0098589 membrane region
GO:0098857 membrane microdomain
GO:0098858 actin-based cell projection
GO:0099568 cytoplasmic region
GO:1990907 beta-catenin-TCF complex
GO:1990909 Wnt signalosome
> KEGG and Reactome Pathway
 
KEGG hsa04015 Rap1 signaling pathway
hsa04310 Wnt signaling pathway
hsa04390 Hippo signaling pathway
hsa04510 Focal adhesion
hsa04520 Adherens junction
hsa04550 Signaling pathways regulating pluripotency of stem cells
hsa04670 Leukocyte transendothelial migration
hsa04916 Melanogenesis
hsa04919 Thyroid hormone signaling pathway
Reactome R-HSA-418990: Adherens junctions interactions
R-HSA-109581: Apoptosis
R-HSA-351906: Apoptotic cleavage of cell adhesion proteins
R-HSA-111465: Apoptotic cleavage of cellular proteins
R-HSA-75153: Apoptotic execution phase
R-HSA-3858494: Beta-catenin independent WNT signaling
R-HSA-196299: Beta-catenin phosphorylation cascade
R-HSA-4411364: Binding of TCF/LEF
R-HSA-375170: CDO in myogenesis
R-HSA-4086398: Ca2+ pathway
R-HSA-446728: Cell junction organization
R-HSA-1500931: Cell-Cell communication
R-HSA-421270: Cell-cell junction organization
R-HSA-1834949: Cytosolic sensors of pathogen-associated DNA
R-HSA-3769402: Deactivation of the beta-catenin transactivating complex
R-HSA-195253: Degradation of beta-catenin by the destruction complex
R-HSA-1266738: Developmental Biology
R-HSA-4641262: Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-201722: Formation of the beta-catenin
R-HSA-168256: Immune System
R-HSA-400508: Incretin synthesis, secretion, and inactivation
R-HSA-5663205: Infectious disease
R-HSA-8876493: InlA-mediated entry of Listeria monocytogenes into host cells
R-HSA-168249: Innate Immune System
R-HSA-3134973: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
R-HSA-8876384: Listeria monocytogenes entry into host cells
R-HSA-392499: Metabolism of proteins
R-HSA-5339716: Misspliced GSK3beta mutants stabilize beta-catenin
R-HSA-525793: Myogenesis
R-HSA-2980736: Peptide hormone metabolism
R-HSA-5357801: Programmed Cell Death
R-HSA-195258: RHO GTPase Effectors
R-HSA-5626467: RHO GTPases activate IQGAPs
R-HSA-5358747: S33 mutants of beta-catenin aren't phosphorylated
R-HSA-5358749: S37 mutants of beta-catenin aren't phosphorylated
R-HSA-5358751: S45 mutants of beta-catenin aren't phosphorylated
R-HSA-162582: Signal Transduction
R-HSA-194315: Signaling by Rho GTPases
R-HSA-194138: Signaling by VEGF
R-HSA-4791275: Signaling by WNT in cancer
R-HSA-195721: Signaling by Wnt
R-HSA-381771: Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
R-HSA-5358752: T41 mutants of beta-catenin aren't phosphorylated
R-HSA-201681: TCF dependent signaling in response to WNT
R-HSA-4420097: VEGFA-VEGFR2 Pathway
R-HSA-5218920: VEGFR2 mediated vascular permeability
R-HSA-4839743: phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
Summary
SymbolCTNNB1
Namecatenin (cadherin-associated protein), beta 1, 88kDa
Aliases beta-catenin; armadillo; CTNNB; catenin (cadherin-associated protein), beta 1 (88kD); MRD19; Catenin beta-1
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CTNNB1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between CTNNB1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
27045006Lung CarcinomaPromote immunity (T cell function)Here, we demonstrate that stroma-derived Dickkopf-1 (Dkk1) targets β-catenin in MDSCs, thus exerting immune suppressive effects during tumor progression. Mice bearing extraskeletal tumors show significantly elevated levels of Dkk1 in bone microenvironment relative to tumor site. Strikingly, Dkk1 neutralization decreases tumor growth and MDSC numbers by rescuing β-catenin in these cells and restores T cell recruitment at the tumor site.
26041736MelanomaInhibit immunity (T cell function)This work demonstrates that melanoma-derived Wnt5a ligand upregulates the durable expression and activity of the indoleamine 2,3-dioxygenase-1 (IDO) enzyme by local DCs in a manner that depends upon the β-catenin signaling pathway.
25568183MelanomaInhibit immunity (T cell function)Hence, β-catenin/TCF4 signaling induces local regulatory DC and regulatory T-cell phenotypes via the RA pathway, identifying this pathway as an important target for anticancer immunotherapy.
29678298melanomaInhibit immunityWe propose that targeting Wnt/β-catenin signaling would potentially improve clinical outcomes of cancer patients by overcoming the primary, adaptive, and acquired resistance to immunotherapy.
29664013melanomaInhibit immunityThe 6 subgroups were replicated in The Cancer Genome Atlas (TCGA) melanomas, where β-catenin signaling was also associated with low immune scores predominantly related to hypomethylation.
24023259B16 Malignant MelanomaInhibit immunity (T cell function)B16 melanoma-bearing mice, when vaccinated with DC-targeting anti-DEC-205 mAb fused with tumor antigens, exhibited dampened CD8? immunity, similar to DC-β-catenin(active) mice.
23958949LymphomaInhibit immunityFirst, DD modulated DCs toward tolerance by downregulating costimulatory receptors such as CD83 and CD25 while upregulating tolerance-associated proteins/pathways including Stat-3, β-catenin, and class II transactivator-dependent antigen presentation.
29104081Colon CacinomaPromote immunityOur results also showed that enhancement of the cytolytic activity of γδT cells against human colon cancer cells by TWS119 was chiefly associated with upregulation of the expression of perforin and granzyme B in vitro and in vivo.
29510987Colorectal CarcinomaInhibit immunity (infiltration)WNT/β-catenin signaling genes were significantly mutated in all CRC subtypes, and activated WNT/β-catenin signaling was correlated with the absence of T-cell infiltration.
24127488Lung Carcinoma; Pancreatic CarcinomaPromote immunityConsistent with a negative role for β-catenin in MDSCs, its deletion in the myeloid population leads to MDSC accumulation and supports tumor progression, whereas expression of β-catenin constitutively active reduces MDSC numbers and protects from tumor growth. Further emphasizing the clinical relevance of these findings, MDSCs isolated from pancreatic cancer patients show reduced p-PLCγ2 and β-catenin levels compared with healthy controls, similar to tumor-bearing mice.
22815287MelanomaInhibit immunityImmune suppression and resistance mediated by constitutive activation of Wnt/β-catenin signaling in human melanoma cells. IL-10 expression was associated with β-catenin accumulation in human melanoma cell lines and tissues and was induced by direct β-catenin/TCF binding to the IL-10 promoter. Murine splenic and tumor-infiltrating DCs obtained from nude mice implanted with human mutant β-catenin-overexpressed melanoma cells had less ability to activate T cells than did DCs from mice with control melanoma cells, showing in vivo suppression of DCs by activated Wnt/β-catenin signaling in human melanoma. β-catenin-overexpressed melanoma inhibited IFN-γ production by melanoma-specific CTLs in an IL-10-independent manner and is more resistant to CTL lysis in vitro and in vivo.
29771197Head and Neck CarcinomaInhibit immunityIn addition to its effects on tumor epithelia, β-catenin activity regulates the tumor microenvironment by regulating extracellular matrix remodeling, fibrotic processes, and immune response.
Summary
SymbolCTNNB1
Namecatenin (cadherin-associated protein), beta 1, 88kDa
Aliases beta-catenin; armadillo; CTNNB; catenin (cadherin-associated protein), beta 1 (88kD); MRD19; Catenin beta-1
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CTNNB1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCTNNB1
Namecatenin (cadherin-associated protein), beta 1, 88kDa
Aliases beta-catenin; armadillo; CTNNB; catenin (cadherin-associated protein), beta 1 (88kD); MRD19; Catenin beta-1
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CTNNB1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.5380.133
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.9050.796
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.2690.917
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0830.81
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0470.986
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2480.943
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.3620.522
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0820.975
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.8080.78
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2570.894
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.150.693
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1070.128
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CTNNB1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103033.3-33.30.231
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277318.54.114.40.0315
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275918.55.113.40.102
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 592011.18.91
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCTNNB1
Namecatenin (cadherin-associated protein), beta 1, 88kDa
Aliases beta-catenin; armadillo; CTNNB; catenin (cadherin-associated protein), beta 1 (88kD); MRD19; Catenin beta-1
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CTNNB1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCTNNB1
Namecatenin (cadherin-associated protein), beta 1, 88kDa
Aliases beta-catenin; armadillo; CTNNB; catenin (cadherin-associated protein), beta 1 (88kD); MRD19; Catenin beta-1
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CTNNB1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CTNNB1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCTNNB1
Namecatenin (cadherin-associated protein), beta 1, 88kDa
Aliases beta-catenin; armadillo; CTNNB; catenin (cadherin-associated protein), beta 1 (88kD); MRD19; Catenin beta-1
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CTNNB1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCTNNB1
Namecatenin (cadherin-associated protein), beta 1, 88kDa
Aliases beta-catenin; armadillo; CTNNB; catenin (cadherin-associated protein), beta 1 (88kD); MRD19; Catenin beta-1
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CTNNB1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCTNNB1
Namecatenin (cadherin-associated protein), beta 1, 88kDa
Aliases beta-catenin; armadillo; CTNNB; catenin (cadherin-associated protein), beta 1 (88kD); MRD19; Catenin beta-1
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CTNNB1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCTNNB1
Namecatenin (cadherin-associated protein), beta 1, 88kDa
Aliases beta-catenin; armadillo; CTNNB; catenin (cadherin-associated protein), beta 1 (88kD); MRD19; Catenin beta-1
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CTNNB1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting CTNNB1.
ID Name Drug Type Targets #Targets
DB03904UreaSmall MoleculeARG1, CA2, CTNNB13