TISIDB

Summary
Symbol	CTPS1
Name	CTP synthase 1
Aliases	CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ......
Chromosomal Location	1p34.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	-
Domain	PF06418 CTP synthase N-terminus PF00117 Glutamine amidotransferase class-I
Function	This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity.

> Gene Ontology [ TOP ]
Biological Process	GO:0006213 pyrimidine nucleoside metabolic process GO:0006220 pyrimidine nucleotide metabolic process GO:0006221 pyrimidine nucleotide biosynthetic process GO:0006241 CTP biosynthetic process GO:0006520 cellular amino acid metabolic process GO:0006541 glutamine metabolic process GO:0007159 leukocyte cell-cell adhesion GO:0009064 glutamine family amino acid metabolic process GO:0009116 nucleoside metabolic process GO:0009119 ribonucleoside metabolic process GO:0009141 nucleoside triphosphate metabolic process GO:0009142 nucleoside triphosphate biosynthetic process GO:0009147 pyrimidine nucleoside triphosphate metabolic process GO:0009148 pyrimidine nucleoside triphosphate biosynthetic process GO:0009163 nucleoside biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0009199 ribonucleoside triphosphate metabolic process GO:0009201 ribonucleoside triphosphate biosynthetic process GO:0009208 pyrimidine ribonucleoside triphosphate metabolic process GO:0009209 pyrimidine ribonucleoside triphosphate biosynthetic process GO:0009218 pyrimidine ribonucleotide metabolic process GO:0009220 pyrimidine ribonucleotide biosynthetic process GO:0009260 ribonucleotide biosynthetic process GO:0015949 nucleobase-containing small molecule interconversion GO:0032943 mononuclear cell proliferation GO:0042098 T cell proliferation GO:0042100 B cell proliferation GO:0042110 T cell activation GO:0042113 B cell activation GO:0042455 ribonucleoside biosynthetic process GO:0042493 response to drug GO:0044210 'de novo' CTP biosynthetic process GO:0046036 CTP metabolic process GO:0046131 pyrimidine ribonucleoside metabolic process GO:0046132 pyrimidine ribonucleoside biosynthetic process GO:0046134 pyrimidine nucleoside biosynthetic process GO:0046390 ribose phosphate biosynthetic process GO:0046651 lymphocyte proliferation GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0071593 lymphocyte aggregation GO:0072527 pyrimidine-containing compound metabolic process GO:0072528 pyrimidine-containing compound biosynthetic process GO:1901293 nucleoside phosphate biosynthetic process GO:1901605 alpha-amino acid metabolic process GO:1901657 glycosyl compound metabolic process GO:1901659 glycosyl compound biosynthetic process
Molecular Function	GO:0003883 CTP synthase activity GO:0016874 ligase activity GO:0016879 ligase activity, forming carbon-nitrogen bonds
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa00240 Pyrimidine metabolism hsa01100 Metabolic pathways
Reactome	R-HSA-1430728: Metabolism R-HSA-15869: Metabolism of nucleotides R-HSA-499943: Synthesis and interconversion of nucleotide di- and triphosphates

Summary
Symbol	CTPS1
Name	CTP synthase 1
Aliases	CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ......
Chromosomal Location	1p34.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between CTPS1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	CTPS1
Name	CTP synthase 1
Aliases	CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ......
Chromosomal Location	1p34.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of CTPS1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	logFC: -1.69; FDR: 0.04110	Resistant to T cell-mediated killing
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	CTPS1
Name	CTP synthase 1
Aliases	CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ......
Chromosomal Location	1p34.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of CTPS1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.304	0.191
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.155	0.935
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.411	0.765
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.138	0.646
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.257	0.896
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.017	0.995
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.063	0.875
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.393	0.802
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.617	0.712
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.572	0.619
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.233	0.881
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.33	0.00119

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of CTPS1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	1.4	2.3	0.469
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	1.7	2	0.532
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	6.2	4.9	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	20	11.1	8.9	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	7.7	-7.7	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	8.3	-8.3	1

Summary
Symbol	CTPS1
Name	CTP synthase 1
Aliases	CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ......
Chromosomal Location	1p34.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CTPS1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	CTPS1
Name	CTP synthase 1
Aliases	CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ......
Chromosomal Location	1p34.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CTPS1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CTPS1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	CTPS1
Name	CTP synthase 1
Aliases	CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ......
Chromosomal Location	1p34.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CTPS1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	CTPS1
Name	CTP synthase 1
Aliases	CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ......
Chromosomal Location	1p34.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of CTPS1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	CTPS1
Name	CTP synthase 1
Aliases	CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ......
Chromosomal Location	1p34.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between CTPS1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	CTPS1
Name	CTP synthase 1
Aliases	CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ......
Chromosomal Location	1p34.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting CTPS1 collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting CTPS1.

ID	Name	Drug Type	Targets	#Targets
DB00130	L-Glutamine	Small Molecule	CTPS1, GLUL, PPAT	3

Browse CTPS1