TISIDB

Summary
Symbol	CXCR1
Name	chemokine (C-X-C motif) receptor 1
Aliases	CDw128a; CD181; CMKAR1; interleukin 8 receptor, alpha; C-C; C-C-CKR-1; CD128; IL8R1; IL8RBA; CXC-R1; CXCR-1; ......
Chromosomal Location	2q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cell membrane; Multi-pass membrane protein.
Domain	PF00001 7 transmembrane receptor (rhodopsin family)
Function	Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

> Gene Ontology [ TOP ]
Biological Process	GO:0002407 dendritic cell chemotaxis GO:0006898 receptor-mediated endocytosis GO:0030595 leukocyte chemotaxis GO:0031623 receptor internalization GO:0036336 dendritic cell migration GO:0038112 interleukin-8-mediated signaling pathway GO:0043112 receptor metabolic process GO:0050900 leukocyte migration GO:0060326 cell chemotaxis GO:0070098 chemokine-mediated signaling pathway GO:0098758 response to interleukin-8 GO:0098759 cellular response to interleukin-8
Molecular Function	GO:0001637 G-protein coupled chemoattractant receptor activity GO:0001653 peptide receptor activity GO:0004896 cytokine receptor activity GO:0004918 interleukin-8 receptor activity GO:0004950 chemokine receptor activity GO:0008528 G-protein coupled peptide receptor activity GO:0016494 C-X-C chemokine receptor activity GO:0019955 cytokine binding GO:0019956 chemokine binding GO:0019958 C-X-C chemokine binding GO:0019959 interleukin-8 binding
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04060 Cytokine-cytokine receptor interaction hsa04062 Chemokine signaling pathway hsa04144 Endocytosis
Reactome	R-HSA-380108: Chemokine receptors bind chemokines R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-418594: G alpha (i) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6798695: Neutrophil degranulation R-HSA-375276: Peptide ligand-binding receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR

> KEGG and Reactome Pathway

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KEGG

hsa04060 Cytokine-cytokine receptor interaction
hsa04062 Chemokine signaling pathway
hsa04144 Endocytosis

Reactome

R-HSA-380108: Chemokine receptors bind chemokines
R-HSA-373076: Class A/1 (Rhodopsin-like receptors)
R-HSA-418594: G alpha (i) signalling events
R-HSA-388396: GPCR downstream signaling
R-HSA-500792: GPCR ligand binding
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-6798695: Neutrophil degranulation
R-HSA-375276: Peptide ligand-binding receptors
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR

Summary
Symbol	CXCR1
Name	chemokine (C-X-C motif) receptor 1
Aliases	CDw128a; CD181; CMKAR1; interleukin 8 receptor, alpha; C-C; C-C-CKR-1; CD128; IL8R1; IL8RBA; CXC-R1; CXCR-1; ......
Chromosomal Location	2q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between CXCR1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	CXCR1
Name	chemokine (C-X-C motif) receptor 1
Aliases	CDw128a; CD181; CMKAR1; interleukin 8 receptor, alpha; C-C; C-C-CKR-1; CD128; IL8R1; IL8RBA; CXC-R1; CXCR-1; ......
Chromosomal Location	2q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of CXCR1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	CXCR1
Name	chemokine (C-X-C motif) receptor 1
Aliases	CDw128a; CD181; CMKAR1; interleukin 8 receptor, alpha; C-C; C-C-CKR-1; CD128; IL8R1; IL8RBA; CXC-R1; CXCR-1; ......
Chromosomal Location	2q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of CXCR1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.101	0.791
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.023	0.973
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.148	0.778
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.8	0.257
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-2.19	0.0575
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.951	0.473
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.442	0.571
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.513	0.63
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.026	0.983
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	1.071	0.282
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.544	0.693
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.253	0.374

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of CXCR1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	4.1	-0.4	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	5.1	-1.4	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	0	4.8	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	12.5	0	12.5	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	CXCR1
Name	chemokine (C-X-C motif) receptor 1
Aliases	CDw128a; CD181; CMKAR1; interleukin 8 receptor, alpha; C-C; C-C-CKR-1; CD128; IL8R1; IL8RBA; CXC-R1; CXCR-1; ......
Chromosomal Location	2q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CXCR1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	CXCR1
Name	chemokine (C-X-C motif) receptor 1
Aliases	CDw128a; CD181; CMKAR1; interleukin 8 receptor, alpha; C-C; C-C-CKR-1; CD128; IL8R1; IL8RBA; CXC-R1; CXCR-1; ......
Chromosomal Location	2q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CXCR1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CXCR1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	CXCR1
Name	chemokine (C-X-C motif) receptor 1
Aliases	CDw128a; CD181; CMKAR1; interleukin 8 receptor, alpha; C-C; C-C-CKR-1; CD128; IL8R1; IL8RBA; CXC-R1; CXCR-1; ......
Chromosomal Location	2q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CXCR1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	CXCR1
Name	chemokine (C-X-C motif) receptor 1
Aliases	CDw128a; CD181; CMKAR1; interleukin 8 receptor, alpha; C-C; C-C-CKR-1; CD128; IL8R1; IL8RBA; CXC-R1; CXCR-1; ......
Chromosomal Location	2q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of CXCR1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	CXCR1
Name	chemokine (C-X-C motif) receptor 1
Aliases	CDw128a; CD181; CMKAR1; interleukin 8 receptor, alpha; C-C; C-C-CKR-1; CD128; IL8R1; IL8RBA; CXC-R1; CXCR-1; ......
Chromosomal Location	2q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between CXCR1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	CXCR1
Name	chemokine (C-X-C motif) receptor 1
Aliases	CDw128a; CD181; CMKAR1; interleukin 8 receptor, alpha; C-C; C-C-CKR-1; CD128; IL8R1; IL8RBA; CXC-R1; CXCR-1; ......
Chromosomal Location	2q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting CXCR1 collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting CXCR1.

ID	Name	Drug Type	Targets	#Targets
DB01009	Ketoprofen	Small Molecule	CXCR1, PTGS1, PTGS2	3

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