Summary | |
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Symbol | CXCR5 |
Name | chemokine (C-X-C motif) receptor 5 |
Aliases | MDR15; CD185; BLR1; Burkitt lymphoma receptor 1, GTP-binding protein; Burkitt lymphoma receptor 1, GTP bindi ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Domain |
PF00001 7 transmembrane receptor (rhodopsin family) |
Function |
Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation. |
Biological Process |
GO:0000910 cytokinesis GO:0030595 leukocyte chemotaxis GO:0032465 regulation of cytokinesis GO:0032467 positive regulation of cytokinesis GO:0042113 B cell activation GO:0045787 positive regulation of cell cycle GO:0048535 lymph node development GO:0050900 leukocyte migration GO:0051302 regulation of cell division GO:0051781 positive regulation of cell division GO:0060326 cell chemotaxis GO:0070098 chemokine-mediated signaling pathway GO:0090068 positive regulation of cell cycle process |
Molecular Function |
GO:0001637 G-protein coupled chemoattractant receptor activity GO:0001653 peptide receptor activity GO:0004896 cytokine receptor activity GO:0004950 chemokine receptor activity GO:0008528 G-protein coupled peptide receptor activity GO:0016494 C-X-C chemokine receptor activity |
Cellular Component |
GO:0009897 external side of plasma membrane GO:0098552 side of membrane |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04062 Chemokine signaling pathway |
Reactome |
R-HSA-380108: Chemokine receptors bind chemokines R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-418594: G alpha (i) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-375276: Peptide ligand-binding receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
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Symbol | CXCR5 |
Name | chemokine (C-X-C motif) receptor 5 |
Aliases | MDR15; CD185; BLR1; Burkitt lymphoma receptor 1, GTP-binding protein; Burkitt lymphoma receptor 1, GTP bindi ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CXCR5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CXCR5 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CXCR5 |
Name | chemokine (C-X-C motif) receptor 5 |
Aliases | MDR15; CD185; BLR1; Burkitt lymphoma receptor 1, GTP-binding protein; Burkitt lymphoma receptor 1, GTP bindi ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CXCR5 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CXCR5 |
Name | chemokine (C-X-C motif) receptor 5 |
Aliases | MDR15; CD185; BLR1; Burkitt lymphoma receptor 1, GTP-binding protein; Burkitt lymphoma receptor 1, GTP bindi ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CXCR5 in various data sets.
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Points in the above scatter plot represent the mutation difference of CXCR5 in various data sets.
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Summary | |
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Symbol | CXCR5 |
Name | chemokine (C-X-C motif) receptor 5 |
Aliases | MDR15; CD185; BLR1; Burkitt lymphoma receptor 1, GTP-binding protein; Burkitt lymphoma receptor 1, GTP bindi ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CXCR5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CXCR5 |
Name | chemokine (C-X-C motif) receptor 5 |
Aliases | MDR15; CD185; BLR1; Burkitt lymphoma receptor 1, GTP-binding protein; Burkitt lymphoma receptor 1, GTP bindi ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CXCR5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CXCR5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CXCR5 |
Name | chemokine (C-X-C motif) receptor 5 |
Aliases | MDR15; CD185; BLR1; Burkitt lymphoma receptor 1, GTP-binding protein; Burkitt lymphoma receptor 1, GTP bindi ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CXCR5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CXCR5 |
Name | chemokine (C-X-C motif) receptor 5 |
Aliases | MDR15; CD185; BLR1; Burkitt lymphoma receptor 1, GTP-binding protein; Burkitt lymphoma receptor 1, GTP bindi ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CXCR5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CXCR5 |
Name | chemokine (C-X-C motif) receptor 5 |
Aliases | MDR15; CD185; BLR1; Burkitt lymphoma receptor 1, GTP-binding protein; Burkitt lymphoma receptor 1, GTP bindi ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CXCR5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CXCR5 |
Name | chemokine (C-X-C motif) receptor 5 |
Aliases | MDR15; CD185; BLR1; Burkitt lymphoma receptor 1, GTP-binding protein; Burkitt lymphoma receptor 1, GTP bindi ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CXCR5 collected from DrugBank database. |
There is no record. |