TISIDB

Summary
Symbol	DAO
Name	D-amino-acid oxidase
Aliases	DAMOX; DAAO; OXDA; D-amino acid oxidase
Chromosomal Location	12q24.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Peroxisome.
Domain	PF01266 FAD dependent oxidoreductase
Function	Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.

> Gene Ontology [ TOP ]
Biological Process	GO:0006520 cellular amino acid metabolic process GO:0006522 alanine metabolic process GO:0006524 alanine catabolic process GO:0006560 proline metabolic process GO:0006562 proline catabolic process GO:0006584 catecholamine metabolic process GO:0009063 cellular amino acid catabolic process GO:0009064 glutamine family amino acid metabolic process GO:0009065 glutamine family amino acid catabolic process GO:0009069 serine family amino acid metabolic process GO:0009071 serine family amino acid catabolic process GO:0009078 pyruvate family amino acid metabolic process GO:0009080 pyruvate family amino acid catabolic process GO:0009712 catechol-containing compound metabolic process GO:0009713 catechol-containing compound biosynthetic process GO:0016054 organic acid catabolic process GO:0018958 phenol-containing compound metabolic process GO:0036088 D-serine catabolic process GO:0042416 dopamine biosynthetic process GO:0042417 dopamine metabolic process GO:0042423 catecholamine biosynthetic process GO:0044282 small molecule catabolic process GO:0046144 D-alanine family amino acid metabolic process GO:0046189 phenol-containing compound biosynthetic process GO:0046395 carboxylic acid catabolic process GO:0046416 D-amino acid metabolic process GO:0046436 D-alanine metabolic process GO:0046487 glyoxylate metabolic process GO:0055130 D-alanine catabolic process GO:0070178 D-serine metabolic process GO:1901565 organonitrogen compound catabolic process GO:1901605 alpha-amino acid metabolic process GO:1901606 alpha-amino acid catabolic process GO:1901615 organic hydroxy compound metabolic process GO:1901617 organic hydroxy compound biosynthetic process
Molecular Function	GO:0003884 D-amino-acid oxidase activity GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor GO:0048037 cofactor binding GO:0050660 flavin adenine dinucleotide binding GO:0050662 coenzyme binding GO:0071949 FAD binding
Cellular Component	GO:0005741 mitochondrial outer membrane GO:0005777 peroxisome GO:0005778 peroxisomal membrane GO:0005782 peroxisomal matrix GO:0019867 outer membrane GO:0031903 microbody membrane GO:0031907 microbody lumen GO:0031968 organelle outer membrane GO:0042579 microbody GO:0044438 microbody part GO:0044439 peroxisomal part

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04146 Peroxisome hsa00260 Glycine, serine and threonine metabolism hsa00330 Arginine and proline metabolism hsa00472 D-Arginine and D-ornithine metabolism hsa01100 Metabolic pathways
Reactome	R-HSA-389661: Glyoxylate metabolism and glycine degradation R-HSA-1430728: Metabolism R-HSA-71291: Metabolism of amino acids and derivatives

Summary
Symbol	DAO
Name	D-amino-acid oxidase
Aliases	DAMOX; DAAO; OXDA; D-amino acid oxidase
Chromosomal Location	12q24.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between DAO and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	DAO
Name	D-amino-acid oxidase
Aliases	DAMOX; DAAO; OXDA; D-amino acid oxidase
Chromosomal Location	12q24.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of DAO in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	DAO
Name	D-amino-acid oxidase
Aliases	DAMOX; DAAO; OXDA; D-amino acid oxidase
Chromosomal Location	12q24.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of DAO in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.382	0.294
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.007	0.992
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.664	0.274
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.66	0.291
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.107	0.92
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	1.35	0.238
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.601	0.46
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.511	0.763
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.988	0.53
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.431	0.758
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.381	0.831
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.527	0.0593

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of DAO in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	14.8	2.7	12.1	0.0439
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	14.8	3.4	11.4	0.0746
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	0	4.8	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	0	7.7	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	3.7	-1.1	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	7.7	-3.2	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	DAO
Name	D-amino-acid oxidase
Aliases	DAMOX; DAAO; OXDA; D-amino acid oxidase
Chromosomal Location	12q24.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DAO. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	DAO
Name	D-amino-acid oxidase
Aliases	DAMOX; DAAO; OXDA; D-amino acid oxidase
Chromosomal Location	12q24.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DAO. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DAO. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	DAO
Name	D-amino-acid oxidase
Aliases	DAMOX; DAAO; OXDA; D-amino acid oxidase
Chromosomal Location	12q24.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DAO. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	DAO
Name	D-amino-acid oxidase
Aliases	DAMOX; DAAO; OXDA; D-amino acid oxidase
Chromosomal Location	12q24.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of DAO expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	DAO
Name	D-amino-acid oxidase
Aliases	DAMOX; DAAO; OXDA; D-amino acid oxidase
Chromosomal Location	12q24.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between DAO and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	DAO
Name	D-amino-acid oxidase
Aliases	DAMOX; DAAO; OXDA; D-amino acid oxidase
Chromosomal Location	12q24.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting DAO collected from DrugBank database.

> Drugs from DrugBank database

[ TOP ]

Details on drugs targeting DAO.

ID	Name	Drug Type	Targets	#Targets
DB02838	3,4-Dihydro-2h-Pyrrolium-5-Carboxylate	Small Molecule	DAO	1
DB02988	Imino-Tryptophan	Small Molecule	DAO	1
DB03147	Flavin adenine dinucleotide	Small Molecule	ACAD8, ACADM, ACADS, ACOX1, AIFM1, CYB5R1, CYB5R3, DAO, DLD, DPYD, ......	26
DB03225	D-Tryptophan	Small Molecule	DAO	1
DB03531	Flavin-Adenine Dinucleotide-N5-Isobutyl Ketone	Small Molecule	DAO	1
DB03793	Benzoic Acid	Small Molecule	DAO, HRSP12, PRDX5, RAB9A, SLC15A1	5
DB04166	Anthranilic acid	Small Molecule	DAO, IL4I1	2
DB07979	(2E)-3-(3,4-DIHYDROXYPHENYL)-2-IMINOPROPANOIC ACID	Small Molecule	DAO	1

Browse DAO