TISIDB

Summary
Symbol	DCLK1
Name	doublecortin-like kinase 1
Aliases	KIAA0369; DCLK; DCDC3A; DCAMKL1; doublecortin and CaM kinase-like 1; CLICK1; doublecortin domain-containing ......
Chromosomal Location	13q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	-
Domain	PF03607 Doublecortin PF00069 Protein kinase domain
Function	Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.

> Gene Ontology [ TOP ]
Biological Process	GO:0001764 neuron migration GO:0007034 vacuolar transport GO:0007409 axonogenesis GO:0009615 response to virus GO:0016049 cell growth GO:0016197 endosomal transport GO:0016358 dendrite development GO:0018105 peptidyl-serine phosphorylation GO:0018209 peptidyl-serine modification GO:0021952 central nervous system projection neuron axonogenesis GO:0021953 central nervous system neuron differentiation GO:0021954 central nervous system neuron development GO:0021955 central nervous system neuron axonogenesis GO:0030900 forebrain development GO:0034504 protein localization to nucleus GO:0048588 developmental cell growth GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048675 axon extension GO:0048813 dendrite morphogenesis GO:0060560 developmental growth involved in morphogenesis GO:0061564 axon development GO:1900180 regulation of protein localization to nucleus GO:1900181 negative regulation of protein localization to nucleus GO:1903828 negative regulation of cellular protein localization GO:1990138 neuron projection extension
Molecular Function	GO:0004674 protein serine/threonine kinase activity GO:0005057 receptor signaling protein activity
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	DCLK1
Name	doublecortin-like kinase 1
Aliases	KIAA0369; DCLK; DCDC3A; DCAMKL1; doublecortin and CaM kinase-like 1; CLICK1; doublecortin domain-containing ......
Chromosomal Location	13q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between DCLK1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between DCLK1 and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
29604293	Pancreatic ductal adenocarcinoma; melanoma; colon carcinoma	Inhibit immunity	In human pancreatic tumor tissues, high levels of DCLK1 associated with a shorter median survival time of patients (17.7 months, compared with 26.6 months of patients whose tumors had low levels of DCLK1).

Summary
Symbol	DCLK1
Name	doublecortin-like kinase 1
Aliases	KIAA0369; DCLK; DCDC3A; DCAMKL1; doublecortin and CaM kinase-like 1; CLICK1; doublecortin domain-containing ......
Chromosomal Location	13q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of DCLK1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	DCLK1
Name	doublecortin-like kinase 1
Aliases	KIAA0369; DCLK; DCDC3A; DCAMKL1; doublecortin and CaM kinase-like 1; CLICK1; doublecortin domain-containing ......
Chromosomal Location	13q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of DCLK1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.54	0.352
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	1.009	0.499
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.2	0.862
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-1.238	0.0278
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-1.226	0.547
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-1.254	0.623
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.018	0.969
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.073	0.96
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.08	0.961
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.125	0.901
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.681	0.642
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.358	0.167

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of DCLK1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	5.5	-1.8	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	6.8	-3.1	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	9.5	0	9.5	0.492
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	15.4	0	15.4	0.482
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	12.5	-1.4	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	20	11.1	8.9	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	14.3	-14.3	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	7.9	0	7.9	0.26
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	13.6	0	13.6	0.279
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	DCLK1
Name	doublecortin-like kinase 1
Aliases	KIAA0369; DCLK; DCDC3A; DCAMKL1; doublecortin and CaM kinase-like 1; CLICK1; doublecortin domain-containing ......
Chromosomal Location	13q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DCLK1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	DCLK1
Name	doublecortin-like kinase 1
Aliases	KIAA0369; DCLK; DCDC3A; DCAMKL1; doublecortin and CaM kinase-like 1; CLICK1; doublecortin domain-containing ......
Chromosomal Location	13q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DCLK1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DCLK1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	DCLK1
Name	doublecortin-like kinase 1
Aliases	KIAA0369; DCLK; DCDC3A; DCAMKL1; doublecortin and CaM kinase-like 1; CLICK1; doublecortin domain-containing ......
Chromosomal Location	13q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DCLK1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	DCLK1
Name	doublecortin-like kinase 1
Aliases	KIAA0369; DCLK; DCDC3A; DCAMKL1; doublecortin and CaM kinase-like 1; CLICK1; doublecortin domain-containing ......
Chromosomal Location	13q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of DCLK1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	DCLK1
Name	doublecortin-like kinase 1
Aliases	KIAA0369; DCLK; DCDC3A; DCAMKL1; doublecortin and CaM kinase-like 1; CLICK1; doublecortin domain-containing ......
Chromosomal Location	13q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between DCLK1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	DCLK1
Name	doublecortin-like kinase 1
Aliases	KIAA0369; DCLK; DCDC3A; DCAMKL1; doublecortin and CaM kinase-like 1; CLICK1; doublecortin domain-containing ......
Chromosomal Location	13q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting DCLK1 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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