TISIDB

Summary
Symbol	DCSTAMP
Name	dendrocyte expressed seven transmembrane protein
Aliases	DC-STAMP; FIND; Dendritic cells (DC)-specific transmembrane protein; IL-Four INDuced; TM7SF4; transmembrane ......
Chromosomal Location	8q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cell membrane Multi-pass membrane protein Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane Multi-pass membrane protein Endosome Note=Localizes to the cell surface in osteoclasts and undifferentiated monocytes. Intracellular internalized DCSTAMP is detected in a fraction of RANKL-induced osteoclast precursor. Colocalizes with OS9 in the endoplasmic reticulum (ER) of immature dendritic cell (DC). Translocates from the endoplasmic reticulum to the intermediate/Golgi compartment upon maturation of DC in a OS9-dependent manner. Colocalizes with LAMP1 in endosomes (By similarity).
Domain	PF07782 DC-STAMP-like protein
Function	Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions.

> Gene Ontology [ TOP ]
Biological Process	GO:0000768 syncytium formation by plasma membrane fusion GO:0001558 regulation of cell growth GO:0001773 myeloid dendritic cell activation GO:0001894 tissue homeostasis GO:0002274 myeloid leukocyte activation GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0002761 regulation of myeloid leukocyte differentiation GO:0002763 positive regulation of myeloid leukocyte differentiation GO:0006949 syncytium formation GO:0016049 cell growth GO:0030099 myeloid cell differentiation GO:0030224 monocyte differentiation GO:0030308 negative regulation of cell growth GO:0030316 osteoclast differentiation GO:0032844 regulation of homeostatic process GO:0032846 positive regulation of homeostatic process GO:0034103 regulation of tissue remodeling GO:0034105 positive regulation of tissue remodeling GO:0034238 macrophage fusion GO:0034239 regulation of macrophage fusion GO:0034241 positive regulation of macrophage fusion GO:0034612 response to tumor necrosis factor GO:0036005 response to macrophage colony-stimulating factor GO:0036006 cellular response to macrophage colony-stimulating factor stimulus GO:0043011 myeloid dendritic cell differentiation GO:0045124 regulation of bone resorption GO:0045453 bone resorption GO:0045637 regulation of myeloid cell differentiation GO:0045639 positive regulation of myeloid cell differentiation GO:0045655 regulation of monocyte differentiation GO:0045657 positive regulation of monocyte differentiation GO:0045780 positive regulation of bone resorption GO:0045926 negative regulation of growth GO:0046849 bone remodeling GO:0046850 regulation of bone remodeling GO:0046852 positive regulation of bone remodeling GO:0048771 tissue remodeling GO:0048871 multicellular organismal homeostasis GO:0060142 regulation of syncytium formation by plasma membrane fusion GO:0060143 positive regulation of syncytium formation by plasma membrane fusion GO:0060249 anatomical structure homeostasis GO:0061025 membrane fusion GO:0070670 response to interleukin-4 GO:0071353 cellular response to interleukin-4 GO:0071356 cellular response to tumor necrosis factor GO:0072674 multinuclear osteoclast differentiation GO:0072675 osteoclast fusion GO:0097028 dendritic cell differentiation GO:1902105 regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1903131 mononuclear cell differentiation GO:1903706 regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis
Molecular Function	-
Cellular Component	GO:0005793 endoplasmic reticulum-Golgi intermediate compartment GO:0010008 endosome membrane GO:0030176 integral component of endoplasmic reticulum membrane GO:0031227 intrinsic component of endoplasmic reticulum membrane GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane GO:0044440 endosomal part

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	DCSTAMP
Name	dendrocyte expressed seven transmembrane protein
Aliases	DC-STAMP; FIND; Dendritic cells (DC)-specific transmembrane protein; IL-Four INDuced; TM7SF4; transmembrane ......
Chromosomal Location	8q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between DCSTAMP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	DCSTAMP
Name	dendrocyte expressed seven transmembrane protein
Aliases	DC-STAMP; FIND; Dendritic cells (DC)-specific transmembrane protein; IL-Four INDuced; TM7SF4; transmembrane ......
Chromosomal Location	8q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of DCSTAMP in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	DCSTAMP
Name	dendrocyte expressed seven transmembrane protein
Aliases	DC-STAMP; FIND; Dendritic cells (DC)-specific transmembrane protein; IL-Four INDuced; TM7SF4; transmembrane ......
Chromosomal Location	8q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of DCSTAMP in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-1.619	0.0162
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-2.468	0.0252
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-1	0.305
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-1.502	0.0815
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-1.304	0.312
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-1.75	0.238
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.571	0.471
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-1.866	0.0942
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	1.023	0.39
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.003	0.996
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.876	0.255
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.022	0.94

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of DCSTAMP in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	7.1	5.9	1.2	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	10	0	10	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	7.1	-7.1	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	5.5	-5.5	0.572
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	6.8	-6.8	0.304
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	0	4.8	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	0	7.7	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	11.1	-11.1	0.067
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	7.7	-7.7	0.371
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	14.3	-14.3	0.209
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	DCSTAMP
Name	dendrocyte expressed seven transmembrane protein
Aliases	DC-STAMP; FIND; Dendritic cells (DC)-specific transmembrane protein; IL-Four INDuced; TM7SF4; transmembrane ......
Chromosomal Location	8q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DCSTAMP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	DCSTAMP
Name	dendrocyte expressed seven transmembrane protein
Aliases	DC-STAMP; FIND; Dendritic cells (DC)-specific transmembrane protein; IL-Four INDuced; TM7SF4; transmembrane ......
Chromosomal Location	8q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DCSTAMP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DCSTAMP. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	DCSTAMP
Name	dendrocyte expressed seven transmembrane protein
Aliases	DC-STAMP; FIND; Dendritic cells (DC)-specific transmembrane protein; IL-Four INDuced; TM7SF4; transmembrane ......
Chromosomal Location	8q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DCSTAMP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	DCSTAMP
Name	dendrocyte expressed seven transmembrane protein
Aliases	DC-STAMP; FIND; Dendritic cells (DC)-specific transmembrane protein; IL-Four INDuced; TM7SF4; transmembrane ......
Chromosomal Location	8q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of DCSTAMP expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	DCSTAMP
Name	dendrocyte expressed seven transmembrane protein
Aliases	DC-STAMP; FIND; Dendritic cells (DC)-specific transmembrane protein; IL-Four INDuced; TM7SF4; transmembrane ......
Chromosomal Location	8q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between DCSTAMP and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	DCSTAMP
Name	dendrocyte expressed seven transmembrane protein
Aliases	DC-STAMP; FIND; Dendritic cells (DC)-specific transmembrane protein; IL-Four INDuced; TM7SF4; transmembrane ......
Chromosomal Location	8q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting DCSTAMP collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse DCSTAMP