Summary | |
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Symbol | DHX8 |
Name | DEAH (Asp-Glu-Ala-His) box polypeptide 8 |
Aliases | PRP22; PRPF22; DDX8; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8 (RNA helicase); DEAH box protein 8; RNA ...... |
Chromosomal Location | 17q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF04408 Helicase associated domain (HA2) PF00271 Helicase conserved C-terminal domain PF07717 Oligonucleotide/oligosaccharide-binding (OB)-fold PF00575 S1 RNA binding domain |
Function |
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (PubMed:8608946). |
Biological Process |
GO:0000375 RNA splicing, via transesterification reactions GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile GO:0000398 mRNA splicing, via spliceosome GO:0006397 mRNA processing GO:0008380 RNA splicing |
Molecular Function |
GO:0003724 RNA helicase activity GO:0004004 ATP-dependent RNA helicase activity GO:0004386 helicase activity GO:0008026 ATP-dependent helicase activity GO:0008186 RNA-dependent ATPase activity GO:0016887 ATPase activity GO:0042623 ATPase activity, coupled GO:0070035 purine NTP-dependent helicase activity |
Cellular Component |
GO:0005681 spliceosomal complex GO:0071013 catalytic step 2 spliceosome |
KEGG |
hsa03040 Spliceosome |
Reactome | - |
Summary | |
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Symbol | DHX8 |
Name | DEAH (Asp-Glu-Ala-His) box polypeptide 8 |
Aliases | PRP22; PRPF22; DDX8; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8 (RNA helicase); DEAH box protein 8; RNA ...... |
Chromosomal Location | 17q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between DHX8 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | DHX8 |
Name | DEAH (Asp-Glu-Ala-His) box polypeptide 8 |
Aliases | PRP22; PRPF22; DDX8; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8 (RNA helicase); DEAH box protein 8; RNA ...... |
Chromosomal Location | 17q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of DHX8 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | DHX8 |
Name | DEAH (Asp-Glu-Ala-His) box polypeptide 8 |
Aliases | PRP22; PRPF22; DDX8; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8 (RNA helicase); DEAH box protein 8; RNA ...... |
Chromosomal Location | 17q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of DHX8 in various data sets.
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Points in the above scatter plot represent the mutation difference of DHX8 in various data sets.
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Summary | |
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Symbol | DHX8 |
Name | DEAH (Asp-Glu-Ala-His) box polypeptide 8 |
Aliases | PRP22; PRPF22; DDX8; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8 (RNA helicase); DEAH box protein 8; RNA ...... |
Chromosomal Location | 17q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DHX8. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | DHX8 |
Name | DEAH (Asp-Glu-Ala-His) box polypeptide 8 |
Aliases | PRP22; PRPF22; DDX8; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8 (RNA helicase); DEAH box protein 8; RNA ...... |
Chromosomal Location | 17q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DHX8. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DHX8. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | DHX8 |
Name | DEAH (Asp-Glu-Ala-His) box polypeptide 8 |
Aliases | PRP22; PRPF22; DDX8; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8 (RNA helicase); DEAH box protein 8; RNA ...... |
Chromosomal Location | 17q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DHX8. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | DHX8 |
Name | DEAH (Asp-Glu-Ala-His) box polypeptide 8 |
Aliases | PRP22; PRPF22; DDX8; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8 (RNA helicase); DEAH box protein 8; RNA ...... |
Chromosomal Location | 17q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of DHX8 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | DHX8 |
Name | DEAH (Asp-Glu-Ala-His) box polypeptide 8 |
Aliases | PRP22; PRPF22; DDX8; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8 (RNA helicase); DEAH box protein 8; RNA ...... |
Chromosomal Location | 17q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between DHX8 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | DHX8 |
Name | DEAH (Asp-Glu-Ala-His) box polypeptide 8 |
Aliases | PRP22; PRPF22; DDX8; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8 (RNA helicase); DEAH box protein 8; RNA ...... |
Chromosomal Location | 17q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting DHX8 collected from DrugBank database. |
There is no record. |