Summary | |
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Symbol | DNAJA2 |
Name | DnaJ (Hsp40) homolog, subfamily A, member 2 |
Aliases | HIRIP4; CPR3; DNJ3; DJ3; DJA2; PRO3015; RDJ2; HIRA interacting protein 4; HIRA-interacting protein 4; cell c ...... |
Chromosomal Location | 16q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Lipid-anchor |
Domain |
PF00226 DnaJ domain PF01556 DnaJ C terminal domain PF00684 DnaJ central domain |
Function |
Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). |
Biological Process |
GO:0006457 protein folding GO:0009266 response to temperature stimulus GO:0009408 response to heat GO:0042026 protein refolding |
Molecular Function |
GO:0031072 heat shock protein binding GO:0051082 unfolded protein binding GO:0051087 chaperone binding |
Cellular Component | - |
KEGG |
hsa04141 Protein processing in endoplasmic reticulum |
Reactome | - |
Summary | |
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Symbol | DNAJA2 |
Name | DnaJ (Hsp40) homolog, subfamily A, member 2 |
Aliases | HIRIP4; CPR3; DNJ3; DJ3; DJA2; PRO3015; RDJ2; HIRA interacting protein 4; HIRA-interacting protein 4; cell c ...... |
Chromosomal Location | 16q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between DNAJA2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | DNAJA2 |
Name | DnaJ (Hsp40) homolog, subfamily A, member 2 |
Aliases | HIRIP4; CPR3; DNJ3; DJ3; DJA2; PRO3015; RDJ2; HIRA interacting protein 4; HIRA-interacting protein 4; cell c ...... |
Chromosomal Location | 16q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of DNAJA2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | DNAJA2 |
Name | DnaJ (Hsp40) homolog, subfamily A, member 2 |
Aliases | HIRIP4; CPR3; DNJ3; DJ3; DJA2; PRO3015; RDJ2; HIRA interacting protein 4; HIRA-interacting protein 4; cell c ...... |
Chromosomal Location | 16q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of DNAJA2 in various data sets.
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Points in the above scatter plot represent the mutation difference of DNAJA2 in various data sets.
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Summary | |
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Symbol | DNAJA2 |
Name | DnaJ (Hsp40) homolog, subfamily A, member 2 |
Aliases | HIRIP4; CPR3; DNJ3; DJ3; DJA2; PRO3015; RDJ2; HIRA interacting protein 4; HIRA-interacting protein 4; cell c ...... |
Chromosomal Location | 16q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DNAJA2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | DNAJA2 |
Name | DnaJ (Hsp40) homolog, subfamily A, member 2 |
Aliases | HIRIP4; CPR3; DNJ3; DJ3; DJA2; PRO3015; RDJ2; HIRA interacting protein 4; HIRA-interacting protein 4; cell c ...... |
Chromosomal Location | 16q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DNAJA2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DNAJA2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | DNAJA2 |
Name | DnaJ (Hsp40) homolog, subfamily A, member 2 |
Aliases | HIRIP4; CPR3; DNJ3; DJ3; DJA2; PRO3015; RDJ2; HIRA interacting protein 4; HIRA-interacting protein 4; cell c ...... |
Chromosomal Location | 16q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DNAJA2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | DNAJA2 |
Name | DnaJ (Hsp40) homolog, subfamily A, member 2 |
Aliases | HIRIP4; CPR3; DNJ3; DJ3; DJA2; PRO3015; RDJ2; HIRA interacting protein 4; HIRA-interacting protein 4; cell c ...... |
Chromosomal Location | 16q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of DNAJA2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | DNAJA2 |
Name | DnaJ (Hsp40) homolog, subfamily A, member 2 |
Aliases | HIRIP4; CPR3; DNJ3; DJ3; DJA2; PRO3015; RDJ2; HIRA interacting protein 4; HIRA-interacting protein 4; cell c ...... |
Chromosomal Location | 16q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between DNAJA2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | DNAJA2 |
Name | DnaJ (Hsp40) homolog, subfamily A, member 2 |
Aliases | HIRIP4; CPR3; DNJ3; DJ3; DJA2; PRO3015; RDJ2; HIRA interacting protein 4; HIRA-interacting protein 4; cell c ...... |
Chromosomal Location | 16q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting DNAJA2 collected from DrugBank database. |
There is no record. |