Browse DNAJC5

Summary
SymbolDNAJC5
NameDnaJ (Hsp40) homolog, subfamily C, member 5
Aliases FLJ00118; FLJ13070; DNAJC5A; CLN4; ceroid-lipofuscinosis, neuronal 4 (Kufs disease); CLN4B; CSPA; mir-941-2; ......
Chromosomal Location20q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane Lipid-anchor Melanosome Cell membrane Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Domain PF00226 DnaJ domain
Function

Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity).

> Gene Ontology
 
Biological Process GO:0001505 regulation of neurotransmitter levels
GO:0006836 neurotransmitter transport
GO:0006887 exocytosis
GO:0007269 neurotransmitter secretion
GO:0016079 synaptic vesicle exocytosis
GO:0017156 calcium ion regulated exocytosis
GO:0023061 signal release
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045055 regulated exocytosis
GO:0048489 synaptic vesicle transport
GO:0051402 neuron apoptotic process
GO:0051640 organelle localization
GO:0051648 vesicle localization
GO:0051650 establishment of vesicle localization
GO:0051656 establishment of organelle localization
GO:0070997 neuron death
GO:0097479 synaptic vesicle localization
GO:0097480 establishment of synaptic vesicle localization
GO:0099003 vesicle-mediated transport in synapse
GO:0099504 synaptic vesicle cycle
GO:0099531 presynaptic process involved in chemical synaptic transmission
GO:0099643 signal release from synapse
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
Molecular Function GO:0001948 glycoprotein binding
GO:0043008 ATP-dependent protein binding
Cellular Component GO:0005765 lysosomal membrane
GO:0008021 synaptic vesicle
GO:0030133 transport vesicle
GO:0030135 coated vesicle
GO:0030136 clathrin-coated vesicle
GO:0030424 axon
GO:0030659 cytoplasmic vesicle membrane
GO:0030662 coated vesicle membrane
GO:0030665 clathrin-coated vesicle membrane
GO:0033267 axon part
GO:0042470 melanosome
GO:0043195 terminal bouton
GO:0043679 axon terminus
GO:0044306 neuron projection terminus
GO:0048770 pigment granule
GO:0060198 clathrin-sculpted vesicle
GO:0061200 clathrin-sculpted gamma-aminobutyric acid transport vesicle
GO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
GO:0070382 exocytic vesicle
GO:0098793 presynapse
GO:0098852 lytic vacuole membrane
GO:0099503 secretory vesicle
> KEGG and Reactome Pathway
 
KEGG hsa04141 Protein processing in endoplasmic reticulum
Reactome R-HSA-888590: GABA synthesis, release, reuptake and degradation
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-112316: Neuronal System
R-HSA-112310: Neurotransmitter Release Cycle
R-HSA-6798695: Neutrophil degranulation
R-HSA-112315: Transmission across Chemical Synapses
Summary
SymbolDNAJC5
NameDnaJ (Hsp40) homolog, subfamily C, member 5
Aliases FLJ00118; FLJ13070; DNAJC5A; CLN4; ceroid-lipofuscinosis, neuronal 4 (Kufs disease); CLN4B; CSPA; mir-941-2; ......
Chromosomal Location20q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between DNAJC5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolDNAJC5
NameDnaJ (Hsp40) homolog, subfamily C, member 5
Aliases FLJ00118; FLJ13070; DNAJC5A; CLN4; ceroid-lipofuscinosis, neuronal 4 (Kufs disease); CLN4B; CSPA; mir-941-2; ......
Chromosomal Location20q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of DNAJC5 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX STARS Score: 3.65; FDR: 0.041 Resistant to T cell-mediated killing
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolDNAJC5
NameDnaJ (Hsp40) homolog, subfamily C, member 5
Aliases FLJ00118; FLJ13070; DNAJC5A; CLN4; ceroid-lipofuscinosis, neuronal 4 (Kufs disease); CLN4B; CSPA; mir-941-2; ......
Chromosomal Location20q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of DNAJC5 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0460.83
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1040.963
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0080.996
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1020.766
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1080.954
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3710.88
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2340.567
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.2290.9
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2810.887
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.5980.683
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.9740.651
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0130.829
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of DNAJC5 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11139.17.71.41
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 6116.7016.71
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolDNAJC5
NameDnaJ (Hsp40) homolog, subfamily C, member 5
Aliases FLJ00118; FLJ13070; DNAJC5A; CLN4; ceroid-lipofuscinosis, neuronal 4 (Kufs disease); CLN4B; CSPA; mir-941-2; ......
Chromosomal Location20q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DNAJC5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolDNAJC5
NameDnaJ (Hsp40) homolog, subfamily C, member 5
Aliases FLJ00118; FLJ13070; DNAJC5A; CLN4; ceroid-lipofuscinosis, neuronal 4 (Kufs disease); CLN4B; CSPA; mir-941-2; ......
Chromosomal Location20q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DNAJC5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DNAJC5.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolDNAJC5
NameDnaJ (Hsp40) homolog, subfamily C, member 5
Aliases FLJ00118; FLJ13070; DNAJC5A; CLN4; ceroid-lipofuscinosis, neuronal 4 (Kufs disease); CLN4B; CSPA; mir-941-2; ......
Chromosomal Location20q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DNAJC5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolDNAJC5
NameDnaJ (Hsp40) homolog, subfamily C, member 5
Aliases FLJ00118; FLJ13070; DNAJC5A; CLN4; ceroid-lipofuscinosis, neuronal 4 (Kufs disease); CLN4B; CSPA; mir-941-2; ......
Chromosomal Location20q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of DNAJC5 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolDNAJC5
NameDnaJ (Hsp40) homolog, subfamily C, member 5
Aliases FLJ00118; FLJ13070; DNAJC5A; CLN4; ceroid-lipofuscinosis, neuronal 4 (Kufs disease); CLN4B; CSPA; mir-941-2; ......
Chromosomal Location20q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between DNAJC5 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolDNAJC5
NameDnaJ (Hsp40) homolog, subfamily C, member 5
Aliases FLJ00118; FLJ13070; DNAJC5A; CLN4; ceroid-lipofuscinosis, neuronal 4 (Kufs disease); CLN4B; CSPA; mir-941-2; ......
Chromosomal Location20q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting DNAJC5 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.