Browse DPM2

Summary
SymbolDPM2
Namedolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
Aliases MGC21559; MGC111193; CDG1U; DPM synthase subunit 2; dolichol-phosphate mannose synthase subunit 2; Dolichol ......
Chromosomal Location9q34.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain PF07297 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)
Function

Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity.

> Gene Ontology
 
Biological Process GO:0006066 alcohol metabolic process
GO:0006486 protein glycosylation
GO:0006487 protein N-linked glycosylation
GO:0006493 protein O-linked glycosylation
GO:0006497 protein lipidation
GO:0006505 GPI anchor metabolic process
GO:0006506 GPI anchor biosynthetic process
GO:0006643 membrane lipid metabolic process
GO:0006644 phospholipid metabolic process
GO:0006650 glycerophospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006664 glycolipid metabolic process
GO:0006720 isoprenoid metabolic process
GO:0008654 phospholipid biosynthetic process
GO:0009100 glycoprotein metabolic process
GO:0009101 glycoprotein biosynthetic process
GO:0009247 glycolipid biosynthetic process
GO:0016093 polyprenol metabolic process
GO:0016254 preassembly of GPI anchor in ER membrane
GO:0018196 peptidyl-asparagine modification
GO:0018279 protein N-linked glycosylation via asparagine
GO:0019348 dolichol metabolic process
GO:0031647 regulation of protein stability
GO:0035268 protein mannosylation
GO:0035269 protein O-linked mannosylation
GO:0042157 lipoprotein metabolic process
GO:0042158 lipoprotein biosynthetic process
GO:0043413 macromolecule glycosylation
GO:0045017 glycerolipid biosynthetic process
GO:0046467 membrane lipid biosynthetic process
GO:0046474 glycerophospholipid biosynthetic process
GO:0046486 glycerolipid metabolic process
GO:0046488 phosphatidylinositol metabolic process
GO:0070085 glycosylation
GO:0097502 mannosylation
GO:1901615 organic hydroxy compound metabolic process
GO:1903509 liposaccharide metabolic process
Molecular Function GO:0000030 mannosyltransferase activity
GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity
GO:0016757 transferase activity, transferring glycosyl groups
GO:0016758 transferase activity, transferring hexosyl groups
Cellular Component GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0031227 intrinsic component of endoplasmic reticulum membrane
GO:0031501 mannosyltransferase complex
GO:0033185 dolichol-phosphate-mannose synthase complex
> KEGG and Reactome Pathway
 
KEGG hsa00510 N-Glycan biosynthesis
hsa00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
hsa01100 Metabolic pathways
Reactome R-HSA-446203: Asparagine N-linked glycosylation
R-HSA-446193: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
R-HSA-392499: Metabolism of proteins
R-HSA-163125: Post-translational modification
R-HSA-597592: Post-translational protein modification
R-HSA-162699: Synthesis of dolichyl-phosphate mannose
R-HSA-162710: Synthesis of glycosylphosphatidylinositol (GPI)
R-HSA-446219: Synthesis of substrates in N-glycan biosythesis
Summary
SymbolDPM2
Namedolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
Aliases MGC21559; MGC111193; CDG1U; DPM synthase subunit 2; dolichol-phosphate mannose synthase subunit 2; Dolichol ......
Chromosomal Location9q34.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between DPM2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolDPM2
Namedolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
Aliases MGC21559; MGC111193; CDG1U; DPM synthase subunit 2; dolichol-phosphate mannose synthase subunit 2; Dolichol ......
Chromosomal Location9q34.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of DPM2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.54 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolDPM2
Namedolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
Aliases MGC21559; MGC111193; CDG1U; DPM synthase subunit 2; dolichol-phosphate mannose synthase subunit 2; Dolichol ......
Chromosomal Location9q34.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of DPM2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.2290.436
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.4080.859
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1030.953
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.7720.0649
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.6240.542
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.9670.486
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1230.923
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1290.927
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1030.951
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.0110.997
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0970.293
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of DPM2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolDPM2
Namedolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
Aliases MGC21559; MGC111193; CDG1U; DPM synthase subunit 2; dolichol-phosphate mannose synthase subunit 2; Dolichol ......
Chromosomal Location9q34.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DPM2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolDPM2
Namedolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
Aliases MGC21559; MGC111193; CDG1U; DPM synthase subunit 2; dolichol-phosphate mannose synthase subunit 2; Dolichol ......
Chromosomal Location9q34.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DPM2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DPM2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolDPM2
Namedolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
Aliases MGC21559; MGC111193; CDG1U; DPM synthase subunit 2; dolichol-phosphate mannose synthase subunit 2; Dolichol ......
Chromosomal Location9q34.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DPM2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolDPM2
Namedolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
Aliases MGC21559; MGC111193; CDG1U; DPM synthase subunit 2; dolichol-phosphate mannose synthase subunit 2; Dolichol ......
Chromosomal Location9q34.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of DPM2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolDPM2
Namedolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
Aliases MGC21559; MGC111193; CDG1U; DPM synthase subunit 2; dolichol-phosphate mannose synthase subunit 2; Dolichol ......
Chromosomal Location9q34.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between DPM2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolDPM2
Namedolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
Aliases MGC21559; MGC111193; CDG1U; DPM synthase subunit 2; dolichol-phosphate mannose synthase subunit 2; Dolichol ......
Chromosomal Location9q34.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting DPM2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.