TISIDB

Summary
Symbol	DSCC1
Name	DNA replication and sister chromatid cohesion 1
Aliases	DCC1; hDCC1; MGC5528; defective in sister chromatid cohesion homolog 1 (S. cerevisiae); defective in sister ......
Chromosomal Location	8q24.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Nucleus
Domain	PF09724 Uncharacterized conserved protein (DUF2036)
Function	Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3.

> Gene Ontology [ TOP ]
Biological Process	GO:0000070 mitotic sister chromatid segregation GO:0000819 sister chromatid segregation GO:0006260 DNA replication GO:0006261 DNA-dependent DNA replication GO:0006275 regulation of DNA replication GO:0006473 protein acetylation GO:0007059 chromosome segregation GO:0007062 sister chromatid cohesion GO:0007064 mitotic sister chromatid cohesion GO:0007067 mitotic nuclear division GO:0034086 maintenance of sister chromatid cohesion GO:0034088 maintenance of mitotic sister chromatid cohesion GO:0034421 post-translational protein acetylation GO:0043543 protein acylation GO:0043687 post-translational protein modification GO:0051052 regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0071897 DNA biosynthetic process GO:0090329 regulation of DNA-dependent DNA replication GO:0098813 nuclear chromosome segregation GO:1900262 regulation of DNA-directed DNA polymerase activity GO:1900264 positive regulation of DNA-directed DNA polymerase activity GO:2000278 regulation of DNA biosynthetic process GO:2000573 positive regulation of DNA biosynthetic process
Molecular Function	GO:0003689 DNA clamp loader activity GO:0008094 DNA-dependent ATPase activity GO:0016887 ATPase activity GO:0033170 protein-DNA loading ATPase activity GO:0042623 ATPase activity, coupled GO:0043142 single-stranded DNA-dependent ATPase activity
Cellular Component	GO:0000775 chromosome, centromeric region GO:0000785 chromatin GO:0031390 Ctf18 RFC-like complex GO:0098687 chromosomal region

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	DSCC1
Name	DNA replication and sister chromatid cohesion 1
Aliases	DCC1; hDCC1; MGC5528; defective in sister chromatid cohesion homolog 1 (S. cerevisiae); defective in sister ......
Chromosomal Location	8q24.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between DSCC1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	DSCC1
Name	DNA replication and sister chromatid cohesion 1
Aliases	DCC1; hDCC1; MGC5528; defective in sister chromatid cohesion homolog 1 (S. cerevisiae); defective in sister ......
Chromosomal Location	8q24.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of DSCC1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	logFC: -2.70; FDR: 0.00545	Resistant to T cell-mediated killing
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	DSCC1
Name	DNA replication and sister chromatid cohesion 1
Aliases	DCC1; hDCC1; MGC5528; defective in sister chromatid cohesion homolog 1 (S. cerevisiae); defective in sister ......
Chromosomal Location	8q24.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of DSCC1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.441	0.0505
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.489	0.633
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.415	0.65
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.164	0.644
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.036	0.974
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.412	0.781
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.041	0.914
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.571	0.622
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.64	0.583
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.415	0.521
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.813	0.376
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.336	0.00299

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of DSCC1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	1.4	2.3	0.469
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	1.7	2	0.532
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	0	2.6	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	6.2	0	6.2	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	DSCC1
Name	DNA replication and sister chromatid cohesion 1
Aliases	DCC1; hDCC1; MGC5528; defective in sister chromatid cohesion homolog 1 (S. cerevisiae); defective in sister ......
Chromosomal Location	8q24.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DSCC1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	DSCC1
Name	DNA replication and sister chromatid cohesion 1
Aliases	DCC1; hDCC1; MGC5528; defective in sister chromatid cohesion homolog 1 (S. cerevisiae); defective in sister ......
Chromosomal Location	8q24.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DSCC1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DSCC1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	DSCC1
Name	DNA replication and sister chromatid cohesion 1
Aliases	DCC1; hDCC1; MGC5528; defective in sister chromatid cohesion homolog 1 (S. cerevisiae); defective in sister ......
Chromosomal Location	8q24.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DSCC1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	DSCC1
Name	DNA replication and sister chromatid cohesion 1
Aliases	DCC1; hDCC1; MGC5528; defective in sister chromatid cohesion homolog 1 (S. cerevisiae); defective in sister ......
Chromosomal Location	8q24.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of DSCC1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	DSCC1
Name	DNA replication and sister chromatid cohesion 1
Aliases	DCC1; hDCC1; MGC5528; defective in sister chromatid cohesion homolog 1 (S. cerevisiae); defective in sister ......
Chromosomal Location	8q24.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between DSCC1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	DSCC1
Name	DNA replication and sister chromatid cohesion 1
Aliases	DCC1; hDCC1; MGC5528; defective in sister chromatid cohesion homolog 1 (S. cerevisiae); defective in sister ......
Chromosomal Location	8q24.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting DSCC1 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse DSCC1