Browse DYNLL2

Summary
SymbolDYNLL2
Namedynein, light chain, LC8-type 2
Aliases MGC17810; DNCL1B; RSPH22; radial spoke 22 homolog (Chlamydomonas); 8 kDa dynein light chain b; DLC8b; radial ......
Chromosomal Location17q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm, cytoskeleton
Domain PF01221 Dynein light chain type 1
Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).

> Gene Ontology
 
Biological Process GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0002478 antigen processing and presentation of exogenous peptide antigen
GO:0002495 antigen processing and presentation of peptide antigen via MHC class II
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0006839 mitochondrial transport
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0006914 autophagy
GO:0007006 mitochondrial membrane organization
GO:0008037 cell recognition
GO:0008038 neuron recognition
GO:0008039 synaptic target recognition
GO:0008637 apoptotic mitochondrial changes
GO:0010821 regulation of mitochondrion organization
GO:0010822 positive regulation of mitochondrion organization
GO:0016236 macroautophagy
GO:0019882 antigen processing and presentation
GO:0019884 antigen processing and presentation of exogenous antigen
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0035794 positive regulation of mitochondrial membrane permeability
GO:0046902 regulation of mitochondrial membrane permeability
GO:0048002 antigen processing and presentation of peptide antigen
GO:0048193 Golgi vesicle transport
GO:0051204 protein insertion into mitochondrial membrane
GO:0051205 protein insertion into membrane
GO:0070585 protein localization to mitochondrion
GO:0072655 establishment of protein localization to mitochondrion
GO:0072657 protein localization to membrane
GO:0090150 establishment of protein localization to membrane
GO:0090559 regulation of membrane permeability
GO:0097345 mitochondrial outer membrane permeabilization
GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death
GO:1903747 regulation of establishment of protein localization to mitochondrion
GO:1903749 positive regulation of establishment of protein localization to mitochondrion
GO:1903829 positive regulation of cellular protein localization
GO:1904951 positive regulation of establishment of protein localization
GO:2001233 regulation of apoptotic signaling pathway
GO:2001235 positive regulation of apoptotic signaling pathway
Molecular Function GO:0003774 motor activity
Cellular Component GO:0005813 centrosome
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0005929 cilium
GO:0015629 actin cytoskeleton
GO:0016459 myosin complex
GO:0030286 dynein complex
GO:0044441 ciliary part
GO:0072372 primary cilium
GO:0097542 ciliary tip
> KEGG and Reactome Pathway
 
KEGG hsa04962 Vasopressin-regulated water reabsorption
Reactome R-HSA-114452: Activation of BH3-only proteins
R-HSA-139910: Activation of BMF and translocation to mitochondria
R-HSA-1280218: Adaptive Immune System
R-HSA-109581: Apoptosis
R-HSA-446203: Asparagine N-linked glycosylation
R-HSA-6811436: COPI-independent Golgi-to-ER retrograde traffic
R-HSA-6807878: COPI-mediated anterograde transport
R-HSA-2262752: Cellular responses to stress
R-HSA-5617833: Cilium Assembly
R-HSA-199977: ER to Golgi Anterograde Transport
R-HSA-8856688: Golgi-to-ER retrograde transport
R-HSA-168256: Immune System
R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-5620924: Intraflagellar transport
R-HSA-109606: Intrinsic Pathway for Apoptosis
R-HSA-2132295: MHC class II antigen presentation
R-HSA-1632852: Macroautophagy
R-HSA-199991: Membrane Trafficking
R-HSA-392499: Metabolism of proteins
R-HSA-1852241: Organelle biogenesis and maintenance
R-HSA-597592: Post-translational protein modification
R-HSA-5357801: Programmed Cell Death
R-HSA-948021: Transport to the Golgi and subsequent modification
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolDYNLL2
Namedynein, light chain, LC8-type 2
Aliases MGC17810; DNCL1B; RSPH22; radial spoke 22 homolog (Chlamydomonas); 8 kDa dynein light chain b; DLC8b; radial ......
Chromosomal Location17q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between DYNLL2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolDYNLL2
Namedynein, light chain, LC8-type 2
Aliases MGC17810; DNCL1B; RSPH22; radial spoke 22 homolog (Chlamydomonas); 8 kDa dynein light chain b; DLC8b; radial ......
Chromosomal Location17q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of DYNLL2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolDYNLL2
Namedynein, light chain, LC8-type 2
Aliases MGC17810; DNCL1B; RSPH22; radial spoke 22 homolog (Chlamydomonas); 8 kDa dynein light chain b; DLC8b; radial ......
Chromosomal Location17q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of DYNLL2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.6810.00351
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.9810.731
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.4690.813
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.250.402
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.0590.971
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.4910.809
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0250.942
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1170.945
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0780.967
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0760.962
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.380.868
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.160.0263
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolDYNLL2
Namedynein, light chain, LC8-type 2
Aliases MGC17810; DNCL1B; RSPH22; radial spoke 22 homolog (Chlamydomonas); 8 kDa dynein light chain b; DLC8b; radial ......
Chromosomal Location17q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DYNLL2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolDYNLL2
Namedynein, light chain, LC8-type 2
Aliases MGC17810; DNCL1B; RSPH22; radial spoke 22 homolog (Chlamydomonas); 8 kDa dynein light chain b; DLC8b; radial ......
Chromosomal Location17q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DYNLL2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DYNLL2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolDYNLL2
Namedynein, light chain, LC8-type 2
Aliases MGC17810; DNCL1B; RSPH22; radial spoke 22 homolog (Chlamydomonas); 8 kDa dynein light chain b; DLC8b; radial ......
Chromosomal Location17q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DYNLL2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolDYNLL2
Namedynein, light chain, LC8-type 2
Aliases MGC17810; DNCL1B; RSPH22; radial spoke 22 homolog (Chlamydomonas); 8 kDa dynein light chain b; DLC8b; radial ......
Chromosomal Location17q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of DYNLL2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolDYNLL2
Namedynein, light chain, LC8-type 2
Aliases MGC17810; DNCL1B; RSPH22; radial spoke 22 homolog (Chlamydomonas); 8 kDa dynein light chain b; DLC8b; radial ......
Chromosomal Location17q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between DYNLL2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolDYNLL2
Namedynein, light chain, LC8-type 2
Aliases MGC17810; DNCL1B; RSPH22; radial spoke 22 homolog (Chlamydomonas); 8 kDa dynein light chain b; DLC8b; radial ......
Chromosomal Location17q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting DYNLL2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.