Summary | |
---|---|
Symbol | EMILIN2 |
Name | elastin microfibril interfacer 2 |
Aliases | FLJ33200; FOAP-10; EMILIN-2; elastin microfibril interface-located protein 2; extracellular glycoprotein EMI ...... |
Chromosomal Location | 18p11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space, extracellular matrix. Note=Found mainly at the interface between amorphous elastin and microfibrils. |
Domain |
PF00386 C1q domain PF07546 EMI domain |
Function |
May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity. |
Biological Process | - |
Molecular Function |
GO:0005201 extracellular matrix structural constituent GO:0030023 extracellular matrix constituent conferring elasticity GO:0097493 structural molecule activity conferring elasticity |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix GO:0005581 collagen trimer |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | EMILIN2 |
Name | elastin microfibril interfacer 2 |
Aliases | FLJ33200; FOAP-10; EMILIN-2; elastin microfibril interface-located protein 2; extracellular glycoprotein EMI ...... |
Chromosomal Location | 18p11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between EMILIN2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | EMILIN2 |
Name | elastin microfibril interfacer 2 |
Aliases | FLJ33200; FOAP-10; EMILIN-2; elastin microfibril interface-located protein 2; extracellular glycoprotein EMI ...... |
Chromosomal Location | 18p11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of EMILIN2 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | EMILIN2 |
Name | elastin microfibril interfacer 2 |
Aliases | FLJ33200; FOAP-10; EMILIN-2; elastin microfibril interface-located protein 2; extracellular glycoprotein EMI ...... |
Chromosomal Location | 18p11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of EMILIN2 in various data sets.
|
Points in the above scatter plot represent the mutation difference of EMILIN2 in various data sets.
|
Summary | |
---|---|
Symbol | EMILIN2 |
Name | elastin microfibril interfacer 2 |
Aliases | FLJ33200; FOAP-10; EMILIN-2; elastin microfibril interface-located protein 2; extracellular glycoprotein EMI ...... |
Chromosomal Location | 18p11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of EMILIN2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | EMILIN2 |
Name | elastin microfibril interfacer 2 |
Aliases | FLJ33200; FOAP-10; EMILIN-2; elastin microfibril interface-located protein 2; extracellular glycoprotein EMI ...... |
Chromosomal Location | 18p11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of EMILIN2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by EMILIN2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | EMILIN2 |
Name | elastin microfibril interfacer 2 |
Aliases | FLJ33200; FOAP-10; EMILIN-2; elastin microfibril interface-located protein 2; extracellular glycoprotein EMI ...... |
Chromosomal Location | 18p11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of EMILIN2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | EMILIN2 |
Name | elastin microfibril interfacer 2 |
Aliases | FLJ33200; FOAP-10; EMILIN-2; elastin microfibril interface-located protein 2; extracellular glycoprotein EMI ...... |
Chromosomal Location | 18p11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of EMILIN2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | EMILIN2 |
Name | elastin microfibril interfacer 2 |
Aliases | FLJ33200; FOAP-10; EMILIN-2; elastin microfibril interface-located protein 2; extracellular glycoprotein EMI ...... |
Chromosomal Location | 18p11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between EMILIN2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | EMILIN2 |
Name | elastin microfibril interfacer 2 |
Aliases | FLJ33200; FOAP-10; EMILIN-2; elastin microfibril interface-located protein 2; extracellular glycoprotein EMI ...... |
Chromosomal Location | 18p11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting EMILIN2 collected from DrugBank database. |
There is no record. |