Browse ENC1

Summary
SymbolENC1
Nameectodermal-neural cortex 1 (with BTB domain)
Aliases PIG10; ENC-1; TP53I10; KLHL37; kelch-like family member 37; NRPB; ectodermal-neural cortex 1 (with BTB-like ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus matrix Cytoplasm Cytoplasm, cytoskeleton
Domain PF07707 BTB And C-terminal Kelch
PF00651 BTB/POZ domain
PF01344 Kelch motif
Function

Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism.

> Gene Ontology
 
Biological Process GO:0006417 regulation of translation
GO:0010498 proteasomal protein catabolic process
GO:0010499 proteasomal ubiquitin-independent protein catabolic process
GO:0010608 posttranscriptional regulation of gene expression
GO:0010720 positive regulation of cell development
GO:0010975 regulation of neuron projection development
GO:0010976 positive regulation of neuron projection development
GO:0017148 negative regulation of translation
GO:0031346 positive regulation of cell projection organization
GO:0034248 regulation of cellular amide metabolic process
GO:0034249 negative regulation of cellular amide metabolic process
GO:0045666 positive regulation of neuron differentiation
GO:0050769 positive regulation of neurogenesis
GO:0051962 positive regulation of nervous system development
Molecular Function GO:0003779 actin binding
Cellular Component GO:0000151 ubiquitin ligase complex
GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0016363 nuclear matrix
GO:0031461 cullin-RING ubiquitin ligase complex
GO:0031463 Cul3-RING ubiquitin ligase complex
GO:0034399 nuclear periphery
GO:0043025 neuronal cell body
GO:0044297 cell body
GO:0044454 nuclear chromosome part
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolENC1
Nameectodermal-neural cortex 1 (with BTB domain)
Aliases PIG10; ENC-1; TP53I10; KLHL37; kelch-like family member 37; NRPB; ectodermal-neural cortex 1 (with BTB-like ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ENC1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolENC1
Nameectodermal-neural cortex 1 (with BTB domain)
Aliases PIG10; ENC-1; TP53I10; KLHL37; kelch-like family member 37; NRPB; ectodermal-neural cortex 1 (with BTB-like ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ENC1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolENC1
Nameectodermal-neural cortex 1 (with BTB domain)
Aliases PIG10; ENC-1; TP53I10; KLHL37; kelch-like family member 37; NRPB; ectodermal-neural cortex 1 (with BTB-like ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ENC1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.0580.00335
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.3990.388
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.8210.557
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1640.663
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.010.996
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.3540.889
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2280.601
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.2560.882
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2750.881
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.3090.798
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.2930.427
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0150.9
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ENC1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.1011.10.0181
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.1011.10.0286
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolENC1
Nameectodermal-neural cortex 1 (with BTB domain)
Aliases PIG10; ENC-1; TP53I10; KLHL37; kelch-like family member 37; NRPB; ectodermal-neural cortex 1 (with BTB-like ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ENC1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolENC1
Nameectodermal-neural cortex 1 (with BTB domain)
Aliases PIG10; ENC-1; TP53I10; KLHL37; kelch-like family member 37; NRPB; ectodermal-neural cortex 1 (with BTB-like ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ENC1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ENC1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolENC1
Nameectodermal-neural cortex 1 (with BTB domain)
Aliases PIG10; ENC-1; TP53I10; KLHL37; kelch-like family member 37; NRPB; ectodermal-neural cortex 1 (with BTB-like ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ENC1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolENC1
Nameectodermal-neural cortex 1 (with BTB domain)
Aliases PIG10; ENC-1; TP53I10; KLHL37; kelch-like family member 37; NRPB; ectodermal-neural cortex 1 (with BTB-like ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ENC1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolENC1
Nameectodermal-neural cortex 1 (with BTB domain)
Aliases PIG10; ENC-1; TP53I10; KLHL37; kelch-like family member 37; NRPB; ectodermal-neural cortex 1 (with BTB-like ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ENC1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolENC1
Nameectodermal-neural cortex 1 (with BTB domain)
Aliases PIG10; ENC-1; TP53I10; KLHL37; kelch-like family member 37; NRPB; ectodermal-neural cortex 1 (with BTB-like ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ENC1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.