Browse ENPEP

Summary
SymbolENPEP
Nameglutamyl aminopeptidase (aminopeptidase A)
Aliases gp160; CD249; APA; AP-A; aminopeptidase A; differentiation antigen gp160; CD antigen CD249; Glutamyl aminope ......
Chromosomal Location4q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane; Single-pass type II membrane protein.
Domain PF11838 ERAP1-like C-terminal domain
PF01433 Peptidase family M1
Function

Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells.

> Gene Ontology
 
Biological Process GO:0001525 angiogenesis
GO:0001655 urogenital system development
GO:0001822 kidney development
GO:0001990 regulation of systemic arterial blood pressure by hormone
GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin
GO:0002002 regulation of angiotensin levels in blood
GO:0002003 angiotensin maturation
GO:0002005 angiotensin catabolic process in blood
GO:0003013 circulatory system process
GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal
GO:0003073 regulation of systemic arterial blood pressure
GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin
GO:0007586 digestion
GO:0008015 blood circulation
GO:0008217 regulation of blood pressure
GO:0010817 regulation of hormone levels
GO:0016485 protein processing
GO:0016486 peptide hormone processing
GO:0032835 glomerulus development
GO:0042445 hormone metabolic process
GO:0043171 peptide catabolic process
GO:0044236 multicellular organism metabolic process
GO:0044243 multicellular organism catabolic process
GO:0044254 multicellular organismal protein catabolic process
GO:0044256 protein digestion
GO:0044259 multicellular organismal macromolecule metabolic process
GO:0044266 multicellular organismal macromolecule catabolic process
GO:0044268 multicellular organismal protein metabolic process
GO:0048514 blood vessel morphogenesis
GO:0050886 endocrine process
GO:0051604 protein maturation
GO:0060177 regulation of angiotensin metabolic process
GO:0072001 renal system development
GO:0072006 nephron development
GO:1901565 organonitrogen compound catabolic process
Molecular Function GO:0004177 aminopeptidase activity
GO:0008235 metalloexopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008238 exopeptidase activity
GO:0033218 amide binding
GO:0042277 peptide binding
GO:0070006 metalloaminopeptidase activity
Cellular Component GO:0005765 lysosomal membrane
GO:0005903 brush border
GO:0009897 external side of plasma membrane
GO:0016324 apical plasma membrane
GO:0045177 apical part of cell
GO:0098552 side of membrane
GO:0098852 lytic vacuole membrane
GO:0098862 cluster of actin-based cell projections
> KEGG and Reactome Pathway
 
KEGG hsa04614 Renin-angiotensin system
Reactome R-HSA-2022377: Metabolism of Angiotensinogen to Angiotensins
R-HSA-392499: Metabolism of proteins
R-HSA-2980736: Peptide hormone metabolism
Summary
SymbolENPEP
Nameglutamyl aminopeptidase (aminopeptidase A)
Aliases gp160; CD249; APA; AP-A; aminopeptidase A; differentiation antigen gp160; CD antigen CD249; Glutamyl aminope ......
Chromosomal Location4q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ENPEP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolENPEP
Nameglutamyl aminopeptidase (aminopeptidase A)
Aliases gp160; CD249; APA; AP-A; aminopeptidase A; differentiation antigen gp160; CD antigen CD249; Glutamyl aminope ......
Chromosomal Location4q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ENPEP in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolENPEP
Nameglutamyl aminopeptidase (aminopeptidase A)
Aliases gp160; CD249; APA; AP-A; aminopeptidase A; differentiation antigen gp160; CD antigen CD249; Glutamyl aminope ......
Chromosomal Location4q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ENPEP in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.7710.0361
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.3870.0783
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.320.621
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1470.693
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.2040.909
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.5960.776
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2660.56
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.2250.826
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2580.827
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.8690.624
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.2440.65
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.130.365
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ENPEP in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.85.59.30.206
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.85.19.70.199
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)2117190190.113
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86250250.473
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.4015.40.482
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59200200.357
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 382713.23.79.50.388
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221318.27.710.50.63
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolENPEP
Nameglutamyl aminopeptidase (aminopeptidase A)
Aliases gp160; CD249; APA; AP-A; aminopeptidase A; differentiation antigen gp160; CD antigen CD249; Glutamyl aminope ......
Chromosomal Location4q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ENPEP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolENPEP
Nameglutamyl aminopeptidase (aminopeptidase A)
Aliases gp160; CD249; APA; AP-A; aminopeptidase A; differentiation antigen gp160; CD antigen CD249; Glutamyl aminope ......
Chromosomal Location4q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ENPEP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ENPEP.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolENPEP
Nameglutamyl aminopeptidase (aminopeptidase A)
Aliases gp160; CD249; APA; AP-A; aminopeptidase A; differentiation antigen gp160; CD antigen CD249; Glutamyl aminope ......
Chromosomal Location4q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ENPEP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolENPEP
Nameglutamyl aminopeptidase (aminopeptidase A)
Aliases gp160; CD249; APA; AP-A; aminopeptidase A; differentiation antigen gp160; CD antigen CD249; Glutamyl aminope ......
Chromosomal Location4q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ENPEP expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolENPEP
Nameglutamyl aminopeptidase (aminopeptidase A)
Aliases gp160; CD249; APA; AP-A; aminopeptidase A; differentiation antigen gp160; CD antigen CD249; Glutamyl aminope ......
Chromosomal Location4q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ENPEP and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolENPEP
Nameglutamyl aminopeptidase (aminopeptidase A)
Aliases gp160; CD249; APA; AP-A; aminopeptidase A; differentiation antigen gp160; CD antigen CD249; Glutamyl aminope ......
Chromosomal Location4q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ENPEP collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting ENPEP.
ID Name Drug Type Targets #Targets
DB00142Glutamic AcidSmall MoleculeAADAT, AASS, ABAT, ALDH18A1, ASNS, BCAT1, BCAT2, CCBL2, CPQ, DNPEP ......69