Browse EXOC3L4

Summary
SymbolEXOC3L4
Nameexocyst complex component 3-like 4
Aliases C14orf73; chromosome 14 open reading frame 73; SEC6-like protein C14orf73; Exocyst complex component 3-like ......
Chromosomal Location14q32.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF06046 Exocyst complex component Sec6
Function

-

> Gene Ontology
 
Biological Process GO:0006887 exocytosis
GO:0031503 protein complex localization
GO:0034629 cellular protein complex localization
GO:0051601 exocyst localization
Molecular Function GO:0000149 SNARE binding
Cellular Component GO:0000145 exocyst
GO:0005938 cell cortex
GO:0044448 cell cortex part
GO:0099023 tethring complex
GO:0099568 cytoplasmic region
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolEXOC3L4
Nameexocyst complex component 3-like 4
Aliases C14orf73; chromosome 14 open reading frame 73; SEC6-like protein C14orf73; Exocyst complex component 3-like ......
Chromosomal Location14q32.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between EXOC3L4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolEXOC3L4
Nameexocyst complex component 3-like 4
Aliases C14orf73; chromosome 14 open reading frame 73; SEC6-like protein C14orf73; Exocyst complex component 3-like ......
Chromosomal Location14q32.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of EXOC3L4 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolEXOC3L4
Nameexocyst complex component 3-like 4
Aliases C14orf73; chromosome 14 open reading frame 73; SEC6-like protein C14orf73; Exocyst complex component 3-like ......
Chromosomal Location14q32.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of EXOC3L4 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.3960.314
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.4920.475
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3240.572
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.8590.0392
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.8750.533
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.8420.637
729033130MelanomaallAnti-PD-1 (nivolumab) 26231.1810.137
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15112.1980.0857
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1450.908
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1460.919
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.2120.91
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0840.728
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of EXOC3L4 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolEXOC3L4
Nameexocyst complex component 3-like 4
Aliases C14orf73; chromosome 14 open reading frame 73; SEC6-like protein C14orf73; Exocyst complex component 3-like ......
Chromosomal Location14q32.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of EXOC3L4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolEXOC3L4
Nameexocyst complex component 3-like 4
Aliases C14orf73; chromosome 14 open reading frame 73; SEC6-like protein C14orf73; Exocyst complex component 3-like ......
Chromosomal Location14q32.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of EXOC3L4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by EXOC3L4.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolEXOC3L4
Nameexocyst complex component 3-like 4
Aliases C14orf73; chromosome 14 open reading frame 73; SEC6-like protein C14orf73; Exocyst complex component 3-like ......
Chromosomal Location14q32.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of EXOC3L4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolEXOC3L4
Nameexocyst complex component 3-like 4
Aliases C14orf73; chromosome 14 open reading frame 73; SEC6-like protein C14orf73; Exocyst complex component 3-like ......
Chromosomal Location14q32.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of EXOC3L4 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolEXOC3L4
Nameexocyst complex component 3-like 4
Aliases C14orf73; chromosome 14 open reading frame 73; SEC6-like protein C14orf73; Exocyst complex component 3-like ......
Chromosomal Location14q32.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between EXOC3L4 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolEXOC3L4
Nameexocyst complex component 3-like 4
Aliases C14orf73; chromosome 14 open reading frame 73; SEC6-like protein C14orf73; Exocyst complex component 3-like ......
Chromosomal Location14q32.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting EXOC3L4 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.