Browse F2RL1

Summary
SymbolF2RL1
Namecoagulation factor II (thrombin) receptor-like 1
Aliases proteinase-activated receptor-2; GPR11; G-protein coupled receptor 11; coagulation factor II receptor-like 1 ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane; Multi-pass membrane protein.
Domain PF00001 7 transmembrane receptor (rhodopsin family)
Function

Receptor for trypsin and trypsin-like enzymes coupled to G proteins (PubMed:28445455). Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho (PubMed:28445455). Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Regulates endothelial cell barrier integrity during neutrophil extravasation, probably following proteolytic cleavage by PRTN3 (PubMed:23202369). Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion (PubMed:10086357). Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as GNAQ, GNA11, GNA14, GNA12 and GNA13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed:21627585 can signal through G(i) subunit alpha. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to GNAQ and GNA11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at 'Ser-536'; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of GNAQ and GNA11 and involves promotion of cofilin dephosphorylation and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immnune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders.

> Gene Ontology
 
Biological Process GO:0001818 negative regulation of cytokine production
GO:0001819 positive regulation of cytokine production
GO:0001885 endothelial cell development
GO:0001906 cell killing
GO:0001909 leukocyte mediated cytotoxicity
GO:0001910 regulation of leukocyte mediated cytotoxicity
GO:0001912 positive regulation of leukocyte mediated cytotoxicity
GO:0001933 negative regulation of protein phosphorylation
GO:0001959 regulation of cytokine-mediated signaling pathway
GO:0001960 negative regulation of cytokine-mediated signaling pathway
GO:0001977 renal system process involved in regulation of blood volume
GO:0001990 regulation of systemic arterial blood pressure by hormone
GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin
GO:0001999 renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure
GO:0002001 renin secretion into blood stream
GO:0002064 epithelial cell development
GO:0002218 activation of innate immune response
GO:0002221 pattern recognition receptor signaling pathway
GO:0002224 toll-like receptor signaling pathway
GO:0002263 cell activation involved in immune response
GO:0002274 myeloid leukocyte activation
GO:0002275 myeloid cell activation involved in immune response
GO:0002278 eosinophil activation involved in immune response
GO:0002285 lymphocyte activation involved in immune response
GO:0002286 T cell activation involved in immune response
GO:0002366 leukocyte activation involved in immune response
GO:0002367 cytokine production involved in immune response
GO:0002374 cytokine secretion involved in immune response
GO:0002440 production of molecular mediator of immune response
GO:0002443 leukocyte mediated immunity
GO:0002444 myeloid leukocyte mediated immunity
GO:0002446 neutrophil mediated immunity
GO:0002447 eosinophil mediated immunity
GO:0002521 leukocyte differentiation
GO:0002573 myeloid leukocyte differentiation
GO:0002683 negative regulation of immune system process
GO:0002685 regulation of leukocyte migration
GO:0002687 positive regulation of leukocyte migration
GO:0002688 regulation of leukocyte chemotaxis
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0002694 regulation of leukocyte activation
GO:0002696 positive regulation of leukocyte activation
GO:0002697 regulation of immune effector process
GO:0002699 positive regulation of immune effector process
GO:0002700 regulation of production of molecular mediator of immune response
GO:0002702 positive regulation of production of molecular mediator of immune response
GO:0002703 regulation of leukocyte mediated immunity
GO:0002705 positive regulation of leukocyte mediated immunity
GO:0002718 regulation of cytokine production involved in immune response
GO:0002720 positive regulation of cytokine production involved in immune response
GO:0002739 regulation of cytokine secretion involved in immune response
GO:0002741 positive regulation of cytokine secretion involved in immune response
GO:0002757 immune response-activating signal transduction
GO:0002758 innate immune response-activating signal transduction
GO:0002764 immune response-regulating signaling pathway
GO:0002831 regulation of response to biotic stimulus
GO:0002833 positive regulation of response to biotic stimulus
GO:0002886 regulation of myeloid leukocyte mediated immunity
GO:0002888 positive regulation of myeloid leukocyte mediated immunity
GO:0003013 circulatory system process
GO:0003014 renal system process
GO:0003018 vascular process in circulatory system
GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal
GO:0003071 renal system process involved in regulation of systemic arterial blood pressure
GO:0003073 regulation of systemic arterial blood pressure
GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin
GO:0003093 regulation of glomerular filtration
GO:0003094 glomerular filtration
GO:0003104 positive regulation of glomerular filtration
GO:0003158 endothelium development
GO:0006801 superoxide metabolic process
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0006887 exocytosis
GO:0006909 phagocytosis
GO:0006911 phagocytosis, engulfment
GO:0007015 actin filament organization
GO:0007159 leukocyte cell-cell adhesion
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007254 JNK cascade
GO:0007265 Ras protein signal transduction
GO:0007266 Rho protein signal transduction
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0008015 blood circulation
GO:0008064 regulation of actin polymerization or depolymerization
GO:0008154 actin polymerization or depolymerization
GO:0008217 regulation of blood pressure
GO:0009306 protein secretion
GO:0009615 response to virus
GO:0010324 membrane invagination
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0017157 regulation of exocytosis
GO:0030031 cell projection assembly
GO:0030042 actin filament depolymerization
GO:0030099 myeloid cell differentiation
GO:0030100 regulation of endocytosis
GO:0030193 regulation of blood coagulation
GO:0030335 positive regulation of cell migration
GO:0030595 leukocyte chemotaxis
GO:0030832 regulation of actin filament length
GO:0030834 regulation of actin filament depolymerization
GO:0030836 positive regulation of actin filament depolymerization
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031268 pseudopodium organization
GO:0031269 pseudopodium assembly
GO:0031272 regulation of pseudopodium assembly
GO:0031274 positive regulation of pseudopodium assembly
GO:0031341 regulation of cell killing
GO:0031343 positive regulation of cell killing
GO:0031346 positive regulation of cell projection organization
GO:0031349 positive regulation of defense response
GO:0031640 killing of cells of other organism
GO:0032103 positive regulation of response to external stimulus
GO:0032535 regulation of cellular component size
GO:0032602 chemokine production
GO:0032609 interferon-gamma production
GO:0032611 interleukin-1 beta production
GO:0032612 interleukin-1 production
GO:0032613 interleukin-10 production
GO:0032635 interleukin-6 production
GO:0032637 interleukin-8 production
GO:0032642 regulation of chemokine production
GO:0032675 regulation of interleukin-6 production
GO:0032677 regulation of interleukin-8 production
GO:0032682 negative regulation of chemokine production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032872 regulation of stress-activated MAPK cascade
GO:0032873 negative regulation of stress-activated MAPK cascade
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0032928 regulation of superoxide anion generation
GO:0032930 positive regulation of superoxide anion generation
GO:0032956 regulation of actin cytoskeleton organization
GO:0032970 regulation of actin filament-based process
GO:0032984 macromolecular complex disassembly
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034121 regulation of toll-like receptor signaling pathway
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0034123 positive regulation of toll-like receptor signaling pathway
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034135 regulation of toll-like receptor 2 signaling pathway
GO:0034137 positive regulation of toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034139 regulation of toll-like receptor 3 signaling pathway
GO:0034140 negative regulation of toll-like receptor 3 signaling pathway
GO:0034141 positive regulation of toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034143 regulation of toll-like receptor 4 signaling pathway
GO:0034145 positive regulation of toll-like receptor 4 signaling pathway
GO:0034612 response to tumor necrosis factor
GO:0035023 regulation of Rho protein signal transduction
GO:0035025 positive regulation of Rho protein signal transduction
GO:0035150 regulation of tube size
GO:0035821 modification of morphology or physiology of other organism
GO:0035926 chemokine (C-C motif) ligand 2 secretion
GO:0036230 granulocyte activation
GO:0040017 positive regulation of locomotion
GO:0042110 T cell activation
GO:0042119 neutrophil activation
GO:0042311 vasodilation
GO:0042312 regulation of vasodilation
GO:0042326 negative regulation of phosphorylation
GO:0042554 superoxide anion generation
GO:0042742 defense response to bacterium
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043241 protein complex disassembly
GO:0043243 positive regulation of protein complex disassembly
GO:0043244 regulation of protein complex disassembly
GO:0043299 leukocyte degranulation
GO:0043300 regulation of leukocyte degranulation
GO:0043302 positive regulation of leukocyte degranulation
GO:0043307 eosinophil activation
GO:0043308 eosinophil degranulation
GO:0043309 regulation of eosinophil degranulation
GO:0043311 positive regulation of eosinophil degranulation
GO:0043409 negative regulation of MAPK cascade
GO:0043410 positive regulation of MAPK cascade
GO:0043624 cellular protein complex disassembly
GO:0043900 regulation of multi-organism process
GO:0043902 positive regulation of multi-organism process
GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism
GO:0044057 regulation of system process
GO:0044060 regulation of endocrine process
GO:0044089 positive regulation of cellular component biogenesis
GO:0044364 disruption of cells of other organism
GO:0045055 regulated exocytosis
GO:0045088 regulation of innate immune response
GO:0045089 positive regulation of innate immune response
GO:0045446 endothelial cell differentiation
GO:0045807 positive regulation of endocytosis
GO:0045909 positive regulation of vasodilation
GO:0045921 positive regulation of exocytosis
GO:0046328 regulation of JNK cascade
GO:0046329 negative regulation of JNK cascade
GO:0046330 positive regulation of JNK cascade
GO:0046578 regulation of Ras protein signal transduction
GO:0046579 positive regulation of Ras protein signal transduction
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048017 inositol lipid-mediated signaling
GO:0050663 cytokine secretion
GO:0050701 interleukin-1 secretion
GO:0050702 interleukin-1 beta secretion
GO:0050707 regulation of cytokine secretion
GO:0050708 regulation of protein secretion
GO:0050709 negative regulation of protein secretion
GO:0050710 negative regulation of cytokine secretion
GO:0050714 positive regulation of protein secretion
GO:0050715 positive regulation of cytokine secretion
GO:0050764 regulation of phagocytosis
GO:0050766 positive regulation of phagocytosis
GO:0050817 coagulation
GO:0050818 regulation of coagulation
GO:0050829 defense response to Gram-negative bacterium
GO:0050865 regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0050878 regulation of body fluid levels
GO:0050880 regulation of blood vessel size
GO:0050886 endocrine process
GO:0050900 leukocyte migration
GO:0050918 positive chemotaxis
GO:0050920 regulation of chemotaxis
GO:0050921 positive regulation of chemotaxis
GO:0050926 regulation of positive chemotaxis
GO:0050927 positive regulation of positive chemotaxis
GO:0051047 positive regulation of secretion
GO:0051048 negative regulation of secretion
GO:0051051 negative regulation of transport
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051057 positive regulation of small GTPase mediated signal transduction
GO:0051222 positive regulation of protein transport
GO:0051224 negative regulation of protein transport
GO:0051261 protein depolymerization
GO:0051272 positive regulation of cellular component movement
GO:0051403 stress-activated MAPK cascade
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051493 regulation of cytoskeleton organization
GO:0051495 positive regulation of cytoskeleton organization
GO:0051607 defense response to virus
GO:0051702 interaction with symbiont
GO:0051709 regulation of killing of cells of other organism
GO:0051712 positive regulation of killing of cells of other organism
GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction
GO:0051818 disruption of cells of other organism involved in symbiotic interaction
GO:0051851 modification by host of symbiont morphology or physiology
GO:0051852 disruption by host of symbiont cells
GO:0051873 killing by host of symbiont cells
GO:0051883 killing of cells in other organism involved in symbiotic interaction
GO:0055074 calcium ion homeostasis
GO:0060099 regulation of phagocytosis, engulfment
GO:0060100 positive regulation of phagocytosis, engulfment
GO:0060326 cell chemotaxis
GO:0060491 regulation of cell projection assembly
GO:0060627 regulation of vesicle-mediated transport
GO:0060759 regulation of response to cytokine stimulus
GO:0060761 negative regulation of response to cytokine stimulus
GO:0061028 establishment of endothelial barrier
GO:0061041 regulation of wound healing
GO:0070302 regulation of stress-activated protein kinase signaling cascade
GO:0070303 negative regulation of stress-activated protein kinase signaling cascade
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade
GO:0070371 ERK1 and ERK2 cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0070493 thrombin receptor signaling pathway
GO:0070661 leukocyte proliferation
GO:0070942 neutrophil mediated cytotoxicity
GO:0070943 neutrophil mediated killing of symbiont cell
GO:0070944 neutrophil mediated killing of bacterium
GO:0070945 neutrophil mediated killing of gram-negative bacterium
GO:0070948 regulation of neutrophil mediated cytotoxicity
GO:0070949 regulation of neutrophil mediated killing of symbiont cell
GO:0070950 regulation of neutrophil mediated killing of bacterium
GO:0070951 regulation of neutrophil mediated killing of gram-negative bacterium
GO:0070960 positive regulation of neutrophil mediated cytotoxicity
GO:0070961 positive regulation of neutrophil mediated killing of symbiont cell
GO:0070962 positive regulation of neutrophil mediated killing of bacterium
GO:0070963 positive regulation of neutrophil mediated killing of gram-negative bacterium
GO:0071356 cellular response to tumor necrosis factor
GO:0071593 lymphocyte aggregation
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072567 chemokine (C-X-C motif) ligand 2 production
GO:0072593 reactive oxygen species metabolic process
GO:0072604 interleukin-6 secretion
GO:0072606 interleukin-8 secretion
GO:0072608 interleukin-10 secretion
GO:0072643 interferon-gamma secretion
GO:0090066 regulation of anatomical structure size
GO:0090195 chemokine secretion
GO:0090196 regulation of chemokine secretion
GO:0090198 negative regulation of chemokine secretion
GO:0090322 regulation of superoxide metabolic process
GO:0097028 dendritic cell differentiation
GO:0097029 mature conventional dendritic cell differentiation
GO:0097205 renal filtration
GO:0098542 defense response to other organism
GO:0098801 regulation of renal system process
GO:0099024 plasma membrane invagination
GO:1900046 regulation of hemostasis
GO:1900133 regulation of renin secretion into blood stream
GO:1900135 positive regulation of renin secretion into blood stream
GO:1900424 regulation of defense response to bacterium
GO:1900426 positive regulation of defense response to bacterium
GO:1901879 regulation of protein depolymerization
GO:1901881 positive regulation of protein depolymerization
GO:1902532 negative regulation of intracellular signal transduction
GO:1902566 regulation of eosinophil activation
GO:1902568 positive regulation of eosinophil activation
GO:1903034 regulation of response to wounding
GO:1903305 regulation of regulated secretory pathway
GO:1903307 positive regulation of regulated secretory pathway
GO:1903522 regulation of blood circulation
GO:1903524 positive regulation of blood circulation
GO:1903531 negative regulation of secretion by cell
GO:1903532 positive regulation of secretion by cell
GO:1904950 negative regulation of establishment of protein localization
GO:1904951 positive regulation of establishment of protein localization
GO:1905153 regulation of membrane invagination
GO:1905155 positive regulation of membrane invagination
GO:2000147 positive regulation of cell motility
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000482 regulation of interleukin-8 secretion
GO:2000484 positive regulation of interleukin-8 secretion
GO:2000778 positive regulation of interleukin-6 secretion
Molecular Function GO:0001653 peptide receptor activity
GO:0001965 G-protein alpha-subunit binding
GO:0008528 G-protein coupled peptide receptor activity
GO:0015057 thrombin receptor activity
GO:0031681 G-protein beta-subunit binding
Cellular Component GO:0005769 early endosome
GO:0031143 pseudopodium
> KEGG and Reactome Pathway
 
KEGG hsa04080 Neuroactive ligand-receptor interaction
hsa04750 Inflammatory mediator regulation of TRP channels
Reactome R-HSA-373076: Class A/1 (Rhodopsin-like receptors)
R-HSA-416476: G alpha (q) signalling events
R-HSA-388396: GPCR downstream signaling
R-HSA-500792: GPCR ligand binding
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-375276: Peptide ligand-binding receptors
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
Summary
SymbolF2RL1
Namecoagulation factor II (thrombin) receptor-like 1
Aliases proteinase-activated receptor-2; GPR11; G-protein coupled receptor 11; coagulation factor II receptor-like 1 ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between F2RL1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolF2RL1
Namecoagulation factor II (thrombin) receptor-like 1
Aliases proteinase-activated receptor-2; GPR11; G-protein coupled receptor 11; coagulation factor II receptor-like 1 ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of F2RL1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolF2RL1
Namecoagulation factor II (thrombin) receptor-like 1
Aliases proteinase-activated receptor-2; GPR11; G-protein coupled receptor 11; coagulation factor II receptor-like 1 ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of F2RL1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0840.881
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.6960.488
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3870.589
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.4740.323
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.030.983
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.1090.516
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1770.78
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.8520.406
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.4970.638
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.7190.606
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-1.2410.534
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.6530.000209
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of F2RL1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolF2RL1
Namecoagulation factor II (thrombin) receptor-like 1
Aliases proteinase-activated receptor-2; GPR11; G-protein coupled receptor 11; coagulation factor II receptor-like 1 ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of F2RL1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolF2RL1
Namecoagulation factor II (thrombin) receptor-like 1
Aliases proteinase-activated receptor-2; GPR11; G-protein coupled receptor 11; coagulation factor II receptor-like 1 ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of F2RL1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by F2RL1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolF2RL1
Namecoagulation factor II (thrombin) receptor-like 1
Aliases proteinase-activated receptor-2; GPR11; G-protein coupled receptor 11; coagulation factor II receptor-like 1 ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of F2RL1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolF2RL1
Namecoagulation factor II (thrombin) receptor-like 1
Aliases proteinase-activated receptor-2; GPR11; G-protein coupled receptor 11; coagulation factor II receptor-like 1 ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of F2RL1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolF2RL1
Namecoagulation factor II (thrombin) receptor-like 1
Aliases proteinase-activated receptor-2; GPR11; G-protein coupled receptor 11; coagulation factor II receptor-like 1 ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between F2RL1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolF2RL1
Namecoagulation factor II (thrombin) receptor-like 1
Aliases proteinase-activated receptor-2; GPR11; G-protein coupled receptor 11; coagulation factor II receptor-like 1 ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting F2RL1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.