Browse FABP3

Summary
SymbolFABP3
Namefatty acid binding protein 3, muscle and heart
Aliases H-FABP; O-FABP; mammary-derived growth inhibitor; MDGI; FABP11; fatty acid binding protein 11; fatty acid bi ......
Chromosomal Location1p33-p32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm.
Domain PF00061 Lipocalin / cytosolic fatty-acid binding protein family
Function

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.

> Gene Ontology
 
Biological Process GO:0001101 response to acid chemical
GO:0006631 fatty acid metabolic process
GO:0006638 neutral lipid metabolic process
GO:0006639 acylglycerol metabolic process
GO:0006641 triglyceride metabolic process
GO:0006644 phospholipid metabolic process
GO:0006820 anion transport
GO:0006869 lipid transport
GO:0008654 phospholipid biosynthetic process
GO:0010565 regulation of cellular ketone metabolic process
GO:0010876 lipid localization
GO:0015711 organic anion transport
GO:0015718 monocarboxylic acid transport
GO:0015849 organic acid transport
GO:0015908 fatty acid transport
GO:0015909 long-chain fatty acid transport
GO:0016042 lipid catabolic process
GO:0019216 regulation of lipid metabolic process
GO:0019217 regulation of fatty acid metabolic process
GO:0019395 fatty acid oxidation
GO:0019433 triglyceride catabolic process
GO:0030258 lipid modification
GO:0032868 response to insulin
GO:0034440 lipid oxidation
GO:0042180 cellular ketone metabolic process
GO:0042493 response to drug
GO:0042632 cholesterol homeostasis
GO:0043434 response to peptide hormone
GO:0044242 cellular lipid catabolic process
GO:0044539 long-chain fatty acid import
GO:0045834 positive regulation of lipid metabolic process
GO:0046320 regulation of fatty acid oxidation
GO:0046461 neutral lipid catabolic process
GO:0046464 acylglycerol catabolic process
GO:0046486 glycerolipid metabolic process
GO:0046503 glycerolipid catabolic process
GO:0046889 positive regulation of lipid biosynthetic process
GO:0046890 regulation of lipid biosynthetic process
GO:0046942 carboxylic acid transport
GO:0055088 lipid homeostasis
GO:0055091 phospholipid homeostasis
GO:0055092 sterol homeostasis
GO:0070542 response to fatty acid
GO:0071071 regulation of phospholipid biosynthetic process
GO:0071073 positive regulation of phospholipid biosynthetic process
GO:1901652 response to peptide
GO:1903725 regulation of phospholipid metabolic process
GO:1903727 positive regulation of phospholipid metabolic process
Molecular Function GO:0005319 lipid transporter activity
GO:0005324 long-chain fatty acid transporter activity
GO:0005504 fatty acid binding
GO:0015245 fatty acid transporter activity
GO:0031406 carboxylic acid binding
GO:0033293 monocarboxylic acid binding
GO:0036041 long-chain fatty acid binding
GO:0043168 anion binding
GO:0050543 icosatetraenoic acid binding
GO:0070538 oleic acid binding
Cellular Component GO:0016528 sarcoplasm
> KEGG and Reactome Pathway
 
KEGG hsa03320 PPAR signaling pathway
Reactome R-HSA-163560: Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
R-HSA-73923: Lipid digestion, mobilization, and transport
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
Summary
SymbolFABP3
Namefatty acid binding protein 3, muscle and heart
Aliases H-FABP; O-FABP; mammary-derived growth inhibitor; MDGI; FABP11; fatty acid binding protein 11; fatty acid bi ......
Chromosomal Location1p33-p32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between FABP3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolFABP3
Namefatty acid binding protein 3, muscle and heart
Aliases H-FABP; O-FABP; mammary-derived growth inhibitor; MDGI; FABP11; fatty acid binding protein 11; fatty acid bi ......
Chromosomal Location1p33-p32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of FABP3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolFABP3
Namefatty acid binding protein 3, muscle and heart
Aliases H-FABP; O-FABP; mammary-derived growth inhibitor; MDGI; FABP11; fatty acid binding protein 11; fatty acid bi ......
Chromosomal Location1p33-p32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of FABP3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.450.00751
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.5320.39
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-1.3920.313
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2440.443
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2780.857
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.2020.916
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.330.47
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.3630.762
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.3550.797
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1520.945
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.4010.899
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0150.944
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolFABP3
Namefatty acid binding protein 3, muscle and heart
Aliases H-FABP; O-FABP; mammary-derived growth inhibitor; MDGI; FABP11; fatty acid binding protein 11; fatty acid bi ......
Chromosomal Location1p33-p32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FABP3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolFABP3
Namefatty acid binding protein 3, muscle and heart
Aliases H-FABP; O-FABP; mammary-derived growth inhibitor; MDGI; FABP11; fatty acid binding protein 11; fatty acid bi ......
Chromosomal Location1p33-p32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FABP3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FABP3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolFABP3
Namefatty acid binding protein 3, muscle and heart
Aliases H-FABP; O-FABP; mammary-derived growth inhibitor; MDGI; FABP11; fatty acid binding protein 11; fatty acid bi ......
Chromosomal Location1p33-p32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FABP3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolFABP3
Namefatty acid binding protein 3, muscle and heart
Aliases H-FABP; O-FABP; mammary-derived growth inhibitor; MDGI; FABP11; fatty acid binding protein 11; fatty acid bi ......
Chromosomal Location1p33-p32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of FABP3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolFABP3
Namefatty acid binding protein 3, muscle and heart
Aliases H-FABP; O-FABP; mammary-derived growth inhibitor; MDGI; FABP11; fatty acid binding protein 11; fatty acid bi ......
Chromosomal Location1p33-p32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between FABP3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolFABP3
Namefatty acid binding protein 3, muscle and heart
Aliases H-FABP; O-FABP; mammary-derived growth inhibitor; MDGI; FABP11; fatty acid binding protein 11; fatty acid bi ......
Chromosomal Location1p33-p32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting FABP3 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.