Summary | |
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Symbol | FAM83B |
Name | family with sequence similarity 83, member B |
Aliases | FLJ30642; C6orf143; chromosome 6 open reading frame 143; Protein FAM83B |
Chromosomal Location | 6p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Membrane |
Domain |
PF07894 Protein of unknown function (DUF1669) |
Function |
Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. May activate both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. |
Biological Process |
GO:0007173 epidermal growth factor receptor signaling pathway GO:0038127 ERBB signaling pathway |
Molecular Function |
GO:0005154 epidermal growth factor receptor binding GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding GO:0043548 phosphatidylinositol 3-kinase binding GO:0070851 growth factor receptor binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | FAM83B |
Name | family with sequence similarity 83, member B |
Aliases | FLJ30642; C6orf143; chromosome 6 open reading frame 143; Protein FAM83B |
Chromosomal Location | 6p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FAM83B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | FAM83B |
Name | family with sequence similarity 83, member B |
Aliases | FLJ30642; C6orf143; chromosome 6 open reading frame 143; Protein FAM83B |
Chromosomal Location | 6p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FAM83B in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | FAM83B |
Name | family with sequence similarity 83, member B |
Aliases | FLJ30642; C6orf143; chromosome 6 open reading frame 143; Protein FAM83B |
Chromosomal Location | 6p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FAM83B in various data sets.
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Points in the above scatter plot represent the mutation difference of FAM83B in various data sets.
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Summary | |
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Symbol | FAM83B |
Name | family with sequence similarity 83, member B |
Aliases | FLJ30642; C6orf143; chromosome 6 open reading frame 143; Protein FAM83B |
Chromosomal Location | 6p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FAM83B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | FAM83B |
Name | family with sequence similarity 83, member B |
Aliases | FLJ30642; C6orf143; chromosome 6 open reading frame 143; Protein FAM83B |
Chromosomal Location | 6p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FAM83B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FAM83B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | FAM83B |
Name | family with sequence similarity 83, member B |
Aliases | FLJ30642; C6orf143; chromosome 6 open reading frame 143; Protein FAM83B |
Chromosomal Location | 6p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FAM83B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | FAM83B |
Name | family with sequence similarity 83, member B |
Aliases | FLJ30642; C6orf143; chromosome 6 open reading frame 143; Protein FAM83B |
Chromosomal Location | 6p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FAM83B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | FAM83B |
Name | family with sequence similarity 83, member B |
Aliases | FLJ30642; C6orf143; chromosome 6 open reading frame 143; Protein FAM83B |
Chromosomal Location | 6p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FAM83B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | FAM83B |
Name | family with sequence similarity 83, member B |
Aliases | FLJ30642; C6orf143; chromosome 6 open reading frame 143; Protein FAM83B |
Chromosomal Location | 6p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FAM83B collected from DrugBank database. |
There is no record. |