Browse FGF12

Summary
SymbolFGF12
Namefibroblast growth factor 12
Aliases FHF1; fibroblast growth factor 12B; fibroblast growth factor homologous factor 1; myocyte-activating factor; ......
Chromosomal Location3q28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF00167 Fibroblast growth factor
Function

Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation.

> Gene Ontology
 
Biological Process GO:0001508 action potential
GO:0002028 regulation of sodium ion transport
GO:0003012 muscle system process
GO:0003013 circulatory system process
GO:0003015 heart process
GO:0003254 regulation of membrane depolarization
GO:0006814 sodium ion transport
GO:0006936 muscle contraction
GO:0006941 striated muscle contraction
GO:0007507 heart development
GO:0007626 locomotory behavior
GO:0008015 blood circulation
GO:0008344 adult locomotory behavior
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010765 positive regulation of sodium ion transport
GO:0010959 regulation of metal ion transport
GO:0015672 monovalent inorganic cation transport
GO:0019226 transmission of nerve impulse
GO:0019228 neuronal action potential
GO:0022898 regulation of transmembrane transporter activity
GO:0030048 actin filament-based movement
GO:0030534 adult behavior
GO:0031644 regulation of neurological system process
GO:0032409 regulation of transporter activity
GO:0032410 negative regulation of transporter activity
GO:0032412 regulation of ion transmembrane transporter activity
GO:0032413 negative regulation of ion transmembrane transporter activity
GO:0032844 regulation of homeostatic process
GO:0034762 regulation of transmembrane transport
GO:0034763 negative regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0034766 negative regulation of ion transmembrane transport
GO:0035637 multicellular organismal signaling
GO:0035725 sodium ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0043270 positive regulation of ion transport
GO:0043271 negative regulation of ion transport
GO:0044057 regulation of system process
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0044708 single-organism behavior
GO:0050905 neuromuscular process
GO:0051051 negative regulation of transport
GO:0051899 membrane depolarization
GO:0051969 regulation of transmission of nerve impulse
GO:0060047 heart contraction
GO:0060048 cardiac muscle contraction
GO:0070252 actin-mediated cell contraction
GO:0071774 response to fibroblast growth factor
GO:0086001 cardiac muscle cell action potential
GO:0086002 cardiac muscle cell action potential involved in contraction
GO:0086003 cardiac muscle cell contraction
GO:0098900 regulation of action potential
GO:0098908 regulation of neuronal action potential
GO:1902305 regulation of sodium ion transmembrane transport
GO:1904062 regulation of cation transmembrane transport
GO:1904063 negative regulation of cation transmembrane transport
GO:1905150 regulation of voltage-gated sodium channel activity
GO:2000021 regulation of ion homeostasis
GO:2000649 regulation of sodium ion transmembrane transporter activity
GO:2001257 regulation of cation channel activity
GO:2001258 negative regulation of cation channel activity
Molecular Function GO:0008083 growth factor activity
GO:0016247 channel regulator activity
GO:0017080 sodium channel regulator activity
GO:0044325 ion channel binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04010 MAPK signaling pathway
hsa04014 Ras signaling pathway
hsa04015 Rap1 signaling pathway
hsa04151 PI3K-Akt signaling pathway
hsa04810 Regulation of actin cytoskeleton
Reactome R-HSA-5576891: Cardiac conduction
R-HSA-397014: Muscle contraction
R-HSA-5576892: Phase 0 - rapid depolarisation
Summary
SymbolFGF12
Namefibroblast growth factor 12
Aliases FHF1; fibroblast growth factor 12B; fibroblast growth factor homologous factor 1; myocyte-activating factor; ......
Chromosomal Location3q28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between FGF12 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolFGF12
Namefibroblast growth factor 12
Aliases FHF1; fibroblast growth factor 12B; fibroblast growth factor homologous factor 1; myocyte-activating factor; ......
Chromosomal Location3q28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of FGF12 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: 0.98; FDR: 0.029500 Sensitive to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolFGF12
Namefibroblast growth factor 12
Aliases FHF1; fibroblast growth factor 12B; fibroblast growth factor homologous factor 1; myocyte-activating factor; ......
Chromosomal Location3q28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of FGF12 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0790.784
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1460.79
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0280.949
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2420.593
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1040.939
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.6870.643
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.480.499
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0160.988
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.9050.403
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.230.792
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.5280.15
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.3060.172
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of FGF12 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.16.84.30.443
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.18.52.60.702
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.55.93.61
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.79.1-1.41
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.67.4-4.80.565
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.57.7-3.21
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolFGF12
Namefibroblast growth factor 12
Aliases FHF1; fibroblast growth factor 12B; fibroblast growth factor homologous factor 1; myocyte-activating factor; ......
Chromosomal Location3q28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FGF12. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolFGF12
Namefibroblast growth factor 12
Aliases FHF1; fibroblast growth factor 12B; fibroblast growth factor homologous factor 1; myocyte-activating factor; ......
Chromosomal Location3q28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FGF12. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FGF12.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolFGF12
Namefibroblast growth factor 12
Aliases FHF1; fibroblast growth factor 12B; fibroblast growth factor homologous factor 1; myocyte-activating factor; ......
Chromosomal Location3q28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FGF12. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolFGF12
Namefibroblast growth factor 12
Aliases FHF1; fibroblast growth factor 12B; fibroblast growth factor homologous factor 1; myocyte-activating factor; ......
Chromosomal Location3q28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of FGF12 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolFGF12
Namefibroblast growth factor 12
Aliases FHF1; fibroblast growth factor 12B; fibroblast growth factor homologous factor 1; myocyte-activating factor; ......
Chromosomal Location3q28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between FGF12 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolFGF12
Namefibroblast growth factor 12
Aliases FHF1; fibroblast growth factor 12B; fibroblast growth factor homologous factor 1; myocyte-activating factor; ......
Chromosomal Location3q28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting FGF12 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.