Browse FGF7

Summary
SymbolFGF7
Namefibroblast growth factor 7
Aliases KGF; keratinocyte growth factor; fibroblast growth factor 7 (keratinocyte growth factor); HBGF-7; FGF-7; hep ......
Chromosomal Location15q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted.
Domain PF00167 Fibroblast growth factor
Function

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.

> Gene Ontology
 
Biological Process GO:0001667 ameboidal-type cell migration
GO:0001763 morphogenesis of a branching structure
GO:0001942 hair follicle development
GO:0006644 phospholipid metabolic process
GO:0006650 glycerophospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0007431 salivary gland development
GO:0007435 salivary gland morphogenesis
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008544 epidermis development
GO:0008654 phospholipid biosynthetic process
GO:0010463 mesenchymal cell proliferation
GO:0010631 epithelial cell migration
GO:0010632 regulation of epithelial cell migration
GO:0010634 positive regulation of epithelial cell migration
GO:0010837 regulation of keratinocyte proliferation
GO:0010838 positive regulation of keratinocyte proliferation
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018212 peptidyl-tyrosine modification
GO:0022404 molting cycle process
GO:0022405 hair cycle process
GO:0022612 gland morphogenesis
GO:0030258 lipid modification
GO:0030323 respiratory tube development
GO:0030324 lung development
GO:0030335 positive regulation of cell migration
GO:0031069 hair follicle morphogenesis
GO:0031532 actin cytoskeleton reorganization
GO:0034394 protein localization to cell surface
GO:0035265 organ growth
GO:0035272 exocrine system development
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0040017 positive regulation of locomotion
GO:0042303 molting cycle
GO:0042633 hair cycle
GO:0043588 skin development
GO:0043616 keratinocyte proliferation
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0045017 glycerolipid biosynthetic process
GO:0046474 glycerophospholipid biosynthetic process
GO:0046486 glycerolipid metabolic process
GO:0046488 phosphatidylinositol metabolic process
GO:0046834 lipid phosphorylation
GO:0046854 phosphatidylinositol phosphorylation
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048017 inositol lipid-mediated signaling
GO:0048730 epidermis morphogenesis
GO:0048732 gland development
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918 positive chemotaxis
GO:0051272 positive regulation of cellular component movement
GO:0051302 regulation of cell division
GO:0051546 keratinocyte migration
GO:0051547 regulation of keratinocyte migration
GO:0051549 positive regulation of keratinocyte migration
GO:0051781 positive regulation of cell division
GO:0060425 lung morphogenesis
GO:0060428 lung epithelium development
GO:0060437 lung growth
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0060502 epithelial cell proliferation involved in lung morphogenesis
GO:0060541 respiratory system development
GO:0060638 mesenchymal-epithelial cell signaling
GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0060688 regulation of morphogenesis of a branching structure
GO:0060693 regulation of branching involved in salivary gland morphogenesis
GO:0061033 secretion by lung epithelial cell involved in lung growth
GO:0061138 morphogenesis of a branching epithelium
GO:0071774 response to fibroblast growth factor
GO:0090130 tissue migration
GO:0090132 epithelium migration
GO:0098773 skin epidermis development
GO:1905330 regulation of morphogenesis of an epithelium
GO:2000027 regulation of organ morphogenesis
GO:2000147 positive regulation of cell motility
GO:2000794 regulation of epithelial cell proliferation involved in lung morphogenesis
Molecular Function GO:0004713 protein tyrosine kinase activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005104 fibroblast growth factor receptor binding
GO:0005539 glycosaminoglycan binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0035004 phosphatidylinositol 3-kinase activity
GO:0042056 chemoattractant activity
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0052742 phosphatidylinositol kinase activity
GO:0052813 phosphatidylinositol bisphosphate kinase activity
GO:0070851 growth factor receptor binding
GO:1901681 sulfur compound binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04010 MAPK signaling pathway
hsa04014 Ras signaling pathway
hsa04015 Rap1 signaling pathway
hsa04151 PI3K-Akt signaling pathway
hsa04810 Regulation of actin cytoskeleton
Reactome R-HSA-170984: ARMS-mediated activation
R-HSA-2033519: Activated point mutants of FGFR2
R-HSA-1280218: Adaptive Immune System
R-HSA-422475: Axon guidance
R-HSA-2219530: Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-2172127: DAP12 interactions
R-HSA-2424491: DAP12 signaling
R-HSA-1266738: Developmental Biology
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-186763: Downstream signal transduction
R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR)
R-HSA-5654696: Downstream signaling of activated FGFR2
R-HSA-2871796: FCERI mediated MAPK activation
R-HSA-190241: FGFR2 ligand binding and activation
R-HSA-1839126: FGFR2 mutant receptor activation
R-HSA-190377: FGFR2b ligand binding and activation
R-HSA-5654700: FRS-mediated FGFR2 signaling
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-170968: Frs2-mediated activation
R-HSA-180292: GAB1 signalosome
R-HSA-179812: GRB2 events in EGFR signaling
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-2428924: IGF1R signaling cascade
R-HSA-112399: IRS-mediated signalling
R-HSA-2428928: IRS-related events triggered by IGF1R
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-74751: Insulin receptor signalling cascade
R-HSA-912526: Interleukin receptor SHC signaling
R-HSA-451927: Interleukin-2 signaling
R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling
R-HSA-5683057: MAPK family signaling cascades
R-HSA-5684996: MAPK1/MAPK3 signaling
R-HSA-375165: NCAM signaling for neurite out-growth
R-HSA-187037: NGF signalling via TRKA from the plasma membrane
R-HSA-5654727: Negative regulation of FGFR2 signaling
R-HSA-199418: Negative regulation of the PI3K/AKT network
R-HSA-5654695: PI-3K cascade
R-HSA-109704: PI3K Cascade
R-HSA-2219528: PI3K/AKT Signaling in Cancer
R-HSA-198203: PI3K/AKT activation
R-HSA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-1257604: PIP3 activates AKT signaling
R-HSA-5654221: Phospholipase C-mediated cascade; FGFR2
R-HSA-169893: Prolonged ERK activation events
R-HSA-5673001: RAF/MAP kinase cascade
R-HSA-8853659: RET signaling
R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-5654699: SHC-mediated cascade
R-HSA-180336: SHC1 events in EGFR signaling
R-HSA-112412: SOS-mediated signalling
R-HSA-162582: Signal Transduction
R-HSA-177929: Signaling by EGFR
R-HSA-190236: Signaling by FGFR
R-HSA-1226099: Signaling by FGFR in disease
R-HSA-5654738: Signaling by FGFR2
R-HSA-5655253: Signaling by FGFR2 in disease
R-HSA-372790: Signaling by GPCR
R-HSA-74752: Signaling by Insulin receptor
R-HSA-449147: Signaling by Interleukins
R-HSA-2586552: Signaling by Leptin
R-HSA-186797: Signaling by PDGF
R-HSA-1433557: Signaling by SCF-KIT
R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-194138: Signaling by VEGF
R-HSA-983705: Signaling by the B Cell Receptor (BCR)
R-HSA-166520: Signalling by NGF
R-HSA-187687: Signalling to ERKs
R-HSA-167044: Signalling to RAS
R-HSA-187706: Signalling to p38 via RIT and RIN
R-HSA-4420097: VEGFA-VEGFR2 Pathway
R-HSA-5218921: VEGFR2 mediated cell proliferation
Summary
SymbolFGF7
Namefibroblast growth factor 7
Aliases KGF; keratinocyte growth factor; fibroblast growth factor 7 (keratinocyte growth factor); HBGF-7; FGF-7; hep ......
Chromosomal Location15q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between FGF7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolFGF7
Namefibroblast growth factor 7
Aliases KGF; keratinocyte growth factor; fibroblast growth factor 7 (keratinocyte growth factor); HBGF-7; FGF-7; hep ......
Chromosomal Location15q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of FGF7 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolFGF7
Namefibroblast growth factor 7
Aliases KGF; keratinocyte growth factor; fibroblast growth factor 7 (keratinocyte growth factor); HBGF-7; FGF-7; hep ......
Chromosomal Location15q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of FGF7 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.5970.272
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.4120.707
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.7190.36
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.4940.5
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.9260.556
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0580.977
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0440.935
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0890.942
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0530.967
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.0460.454
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 282.6710.125
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.6150.05
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of FGF7 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolFGF7
Namefibroblast growth factor 7
Aliases KGF; keratinocyte growth factor; fibroblast growth factor 7 (keratinocyte growth factor); HBGF-7; FGF-7; hep ......
Chromosomal Location15q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FGF7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolFGF7
Namefibroblast growth factor 7
Aliases KGF; keratinocyte growth factor; fibroblast growth factor 7 (keratinocyte growth factor); HBGF-7; FGF-7; hep ......
Chromosomal Location15q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FGF7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FGF7.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolFGF7
Namefibroblast growth factor 7
Aliases KGF; keratinocyte growth factor; fibroblast growth factor 7 (keratinocyte growth factor); HBGF-7; FGF-7; hep ......
Chromosomal Location15q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FGF7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolFGF7
Namefibroblast growth factor 7
Aliases KGF; keratinocyte growth factor; fibroblast growth factor 7 (keratinocyte growth factor); HBGF-7; FGF-7; hep ......
Chromosomal Location15q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of FGF7 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolFGF7
Namefibroblast growth factor 7
Aliases KGF; keratinocyte growth factor; fibroblast growth factor 7 (keratinocyte growth factor); HBGF-7; FGF-7; hep ......
Chromosomal Location15q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between FGF7 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolFGF7
Namefibroblast growth factor 7
Aliases KGF; keratinocyte growth factor; fibroblast growth factor 7 (keratinocyte growth factor); HBGF-7; FGF-7; hep ......
Chromosomal Location15q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting FGF7 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.