Summary | |
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Symbol | FGF9 |
Name | fibroblast growth factor 9 |
Aliases | glia-activating factor; fibroblast growth factor 9 (glia-activating factor); FGF-9; GAF; HBFG-9; HBGF-9; SYN ...... |
Chromosomal Location | 13q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF00167 Fibroblast growth factor |
Function |
Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors. |
Biological Process |
GO:0001501 skeletal system development GO:0001503 ossification GO:0001525 angiogenesis GO:0001649 osteoblast differentiation GO:0001654 eye development GO:0002053 positive regulation of mesenchymal cell proliferation GO:0002062 chondrocyte differentiation GO:0006606 protein import into nucleus GO:0006644 phospholipid metabolic process GO:0006650 glycerophospholipid metabolic process GO:0006661 phosphatidylinositol biosynthetic process GO:0006913 nucleocytoplasmic transport GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007224 smoothened signaling pathway GO:0007423 sensory organ development GO:0007507 heart development GO:0007517 muscle organ development GO:0007530 sex determination GO:0007548 sex differentiation GO:0008406 gonad development GO:0008543 fibroblast growth factor receptor signaling pathway GO:0008584 male gonad development GO:0008589 regulation of smoothened signaling pathway GO:0008654 phospholipid biosynthetic process GO:0010463 mesenchymal cell proliferation GO:0010464 regulation of mesenchymal cell proliferation GO:0014065 phosphatidylinositol 3-kinase signaling GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO:0014706 striated muscle tissue development GO:0014855 striated muscle cell proliferation GO:0016055 Wnt signaling pathway GO:0016202 regulation of striated muscle tissue development GO:0017038 protein import GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0021762 substantia nigra development GO:0030111 regulation of Wnt signaling pathway GO:0030177 positive regulation of Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0030238 male sex determination GO:0030258 lipid modification GO:0030323 respiratory tube development GO:0030324 lung development GO:0030326 embryonic limb morphogenesis GO:0030901 midbrain development GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0032924 activin receptor signaling pathway GO:0032925 regulation of activin receptor signaling pathway GO:0032927 positive regulation of activin receptor signaling pathway GO:0033002 muscle cell proliferation GO:0034504 protein localization to nucleus GO:0035107 appendage morphogenesis GO:0035108 limb morphogenesis GO:0035113 embryonic appendage morphogenesis GO:0035265 organ growth GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process GO:0040034 regulation of development, heterochronic GO:0042471 ear morphogenesis GO:0042472 inner ear morphogenesis GO:0043410 positive regulation of MAPK cascade GO:0043583 ear development GO:0044344 cellular response to fibroblast growth factor stimulus GO:0044744 protein targeting to nucleus GO:0045017 glycerolipid biosynthetic process GO:0045137 development of primary sexual characteristics GO:0045844 positive regulation of striated muscle tissue development GO:0045880 positive regulation of smoothened signaling pathway GO:0045927 positive regulation of growth GO:0046474 glycerophospholipid biosynthetic process GO:0046486 glycerolipid metabolic process GO:0046488 phosphatidylinositol metabolic process GO:0046546 development of primary male sexual characteristics GO:0046620 regulation of organ growth GO:0046622 positive regulation of organ growth GO:0046661 male sex differentiation GO:0046834 lipid phosphorylation GO:0046854 phosphatidylinositol phosphorylation GO:0048010 vascular endothelial growth factor receptor signaling pathway GO:0048015 phosphatidylinositol-mediated signaling GO:0048017 inositol lipid-mediated signaling GO:0048505 regulation of timing of cell differentiation GO:0048514 blood vessel morphogenesis GO:0048562 embryonic organ morphogenesis GO:0048565 digestive tract development GO:0048566 embryonic digestive tract development GO:0048568 embryonic organ development GO:0048608 reproductive structure development GO:0048634 regulation of muscle organ development GO:0048636 positive regulation of muscle organ development GO:0048638 regulation of developmental growth GO:0048639 positive regulation of developmental growth GO:0048706 embryonic skeletal system development GO:0048736 appendage development GO:0048738 cardiac muscle tissue development GO:0048839 inner ear development GO:0048857 neural nucleus development GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051216 cartilage development GO:0051302 regulation of cell division GO:0051781 positive regulation of cell division GO:0055017 cardiac muscle tissue growth GO:0055021 regulation of cardiac muscle tissue growth GO:0055023 positive regulation of cardiac muscle tissue growth GO:0055024 regulation of cardiac muscle tissue development GO:0055025 positive regulation of cardiac muscle tissue development GO:0055123 digestive system development GO:0060038 cardiac muscle cell proliferation GO:0060043 regulation of cardiac muscle cell proliferation GO:0060045 positive regulation of cardiac muscle cell proliferation GO:0060070 canonical Wnt signaling pathway GO:0060173 limb development GO:0060419 heart growth GO:0060420 regulation of heart growth GO:0060421 positive regulation of heart growth GO:0060484 lung-associated mesenchyme development GO:0060485 mesenchyme development GO:0060537 muscle tissue development GO:0060541 respiratory system development GO:0060828 regulation of canonical Wnt signaling pathway GO:0061448 connective tissue development GO:0061458 reproductive system development GO:0071774 response to fibroblast growth factor GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090263 positive regulation of canonical Wnt signaling pathway GO:0090287 regulation of cellular response to growth factor stimulus GO:0090596 sensory organ morphogenesis GO:0198738 cell-cell signaling by wnt GO:1901861 regulation of muscle tissue development GO:1901863 positive regulation of muscle tissue development GO:1902593 single-organism nuclear import |
Molecular Function |
GO:0004713 protein tyrosine kinase activity GO:0005085 guanyl-nucleotide exchange factor activity GO:0005088 Ras guanyl-nucleotide exchange factor activity GO:0005104 fibroblast growth factor receptor binding GO:0005539 glycosaminoglycan binding GO:0008083 growth factor activity GO:0008201 heparin binding GO:0016303 1-phosphatidylinositol-3-kinase activity GO:0035004 phosphatidylinositol 3-kinase activity GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0052742 phosphatidylinositol kinase activity GO:0052813 phosphatidylinositol bisphosphate kinase activity GO:0070851 growth factor receptor binding GO:1901681 sulfur compound binding |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix GO:0005604 basement membrane GO:0044420 extracellular matrix component |
KEGG |
hsa04010 MAPK signaling pathway hsa04014 Ras signaling pathway hsa04015 Rap1 signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04810 Regulation of actin cytoskeleton |
Reactome |
R-HSA-170984: ARMS-mediated activation R-HSA-2033519: Activated point mutants of FGFR2 R-HSA-1280218: Adaptive Immune System R-HSA-422475: Axon guidance R-HSA-2219530: Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-186763: Downstream signal transduction R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR) R-HSA-5654687: Downstream signaling of activated FGFR1 R-HSA-5654696: Downstream signaling of activated FGFR2 R-HSA-5654708: Downstream signaling of activated FGFR3 R-HSA-5654716: Downstream signaling of activated FGFR4 R-HSA-2871796: FCERI mediated MAPK activation R-HSA-190242: FGFR1 ligand binding and activation R-HSA-1839124: FGFR1 mutant receptor activation R-HSA-190373: FGFR1c ligand binding and activation R-HSA-190241: FGFR2 ligand binding and activation R-HSA-1839126: FGFR2 mutant receptor activation R-HSA-190375: FGFR2c ligand binding and activation R-HSA-190239: FGFR3 ligand binding and activation R-HSA-2033514: FGFR3 mutant receptor activation R-HSA-190371: FGFR3b ligand binding and activation R-HSA-190372: FGFR3c ligand binding and activation R-HSA-190322: FGFR4 ligand binding and activation R-HSA-5654693: FRS-mediated FGFR1 signaling R-HSA-5654700: FRS-mediated FGFR2 signaling R-HSA-5654706: FRS-mediated FGFR3 signaling R-HSA-5654712: FRS-mediated FGFR4 signaling R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-170968: Frs2-mediated activation R-HSA-180292: GAB1 signalosome R-HSA-179812: GRB2 events in EGFR signaling R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-2428924: IGF1R signaling cascade R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-74751: Insulin receptor signalling cascade R-HSA-912526: Interleukin receptor SHC signaling R-HSA-451927: Interleukin-2 signaling R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling R-HSA-5683057: MAPK family signaling cascades R-HSA-5684996: MAPK1/MAPK3 signaling R-HSA-375165: NCAM signaling for neurite out-growth R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-5654726: Negative regulation of FGFR1 signaling R-HSA-5654727: Negative regulation of FGFR2 signaling R-HSA-5654732: Negative regulation of FGFR3 signaling R-HSA-5654733: Negative regulation of FGFR4 signaling R-HSA-199418: Negative regulation of the PI3K/AKT network R-HSA-5654689: PI-3K cascade R-HSA-5654695: PI-3K cascade R-HSA-5654710: PI-3K cascade R-HSA-5654720: PI-3K cascade R-HSA-109704: PI3K Cascade R-HSA-2219528: PI3K/AKT Signaling in Cancer R-HSA-198203: PI3K/AKT activation R-HSA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-1257604: PIP3 activates AKT signaling R-HSA-5654219: Phospholipase C-mediated cascade R-HSA-5654221: Phospholipase C-mediated cascade; FGFR2 R-HSA-5654227: Phospholipase C-mediated cascade; FGFR3 R-HSA-5654228: Phospholipase C-mediated cascade; FGFR4 R-HSA-169893: Prolonged ERK activation events R-HSA-5673001: RAF/MAP kinase cascade R-HSA-8853659: RET signaling R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-5654688: SHC-mediated cascade R-HSA-5654699: SHC-mediated cascade R-HSA-5654704: SHC-mediated cascade R-HSA-5654719: SHC-mediated cascade R-HSA-180336: SHC1 events in EGFR signaling R-HSA-112412: SOS-mediated signalling R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-190236: Signaling by FGFR R-HSA-1226099: Signaling by FGFR in disease R-HSA-5654736: Signaling by FGFR1 R-HSA-5655302: Signaling by FGFR1 in disease R-HSA-5654738: Signaling by FGFR2 R-HSA-5655253: Signaling by FGFR2 in disease R-HSA-5654741: Signaling by FGFR3 R-HSA-5655332: Signaling by FGFR3 in disease R-HSA-8853338: Signaling by FGFR3 point mutants in cancer R-HSA-5654743: Signaling by FGFR4 R-HSA-372790: Signaling by GPCR R-HSA-74752: Signaling by Insulin receptor R-HSA-449147: Signaling by Interleukins R-HSA-2586552: Signaling by Leptin R-HSA-186797: Signaling by PDGF R-HSA-1433557: Signaling by SCF-KIT R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-194138: Signaling by VEGF R-HSA-1839122: Signaling by activated point mutants of FGFR1 R-HSA-1839130: Signaling by activated point mutants of FGFR3 R-HSA-983705: Signaling by the B Cell Receptor (BCR) R-HSA-166520: Signalling by NGF R-HSA-187687: Signalling to ERKs R-HSA-167044: Signalling to RAS R-HSA-187706: Signalling to p38 via RIT and RIN R-HSA-4420097: VEGFA-VEGFR2 Pathway R-HSA-5218921: VEGFR2 mediated cell proliferation |
Summary | |
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Symbol | FGF9 |
Name | fibroblast growth factor 9 |
Aliases | glia-activating factor; fibroblast growth factor 9 (glia-activating factor); FGF-9; GAF; HBFG-9; HBGF-9; SYN ...... |
Chromosomal Location | 13q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FGF9 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between FGF9 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | FGF9 |
Name | fibroblast growth factor 9 |
Aliases | glia-activating factor; fibroblast growth factor 9 (glia-activating factor); FGF-9; GAF; HBFG-9; HBGF-9; SYN ...... |
Chromosomal Location | 13q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FGF9 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | FGF9 |
Name | fibroblast growth factor 9 |
Aliases | glia-activating factor; fibroblast growth factor 9 (glia-activating factor); FGF-9; GAF; HBFG-9; HBGF-9; SYN ...... |
Chromosomal Location | 13q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FGF9 in various data sets.
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Points in the above scatter plot represent the mutation difference of FGF9 in various data sets.
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Summary | |
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Symbol | FGF9 |
Name | fibroblast growth factor 9 |
Aliases | glia-activating factor; fibroblast growth factor 9 (glia-activating factor); FGF-9; GAF; HBFG-9; HBGF-9; SYN ...... |
Chromosomal Location | 13q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FGF9. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | FGF9 |
Name | fibroblast growth factor 9 |
Aliases | glia-activating factor; fibroblast growth factor 9 (glia-activating factor); FGF-9; GAF; HBFG-9; HBGF-9; SYN ...... |
Chromosomal Location | 13q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FGF9. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FGF9. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | FGF9 |
Name | fibroblast growth factor 9 |
Aliases | glia-activating factor; fibroblast growth factor 9 (glia-activating factor); FGF-9; GAF; HBFG-9; HBGF-9; SYN ...... |
Chromosomal Location | 13q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FGF9. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | FGF9 |
Name | fibroblast growth factor 9 |
Aliases | glia-activating factor; fibroblast growth factor 9 (glia-activating factor); FGF-9; GAF; HBFG-9; HBGF-9; SYN ...... |
Chromosomal Location | 13q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FGF9 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | FGF9 |
Name | fibroblast growth factor 9 |
Aliases | glia-activating factor; fibroblast growth factor 9 (glia-activating factor); FGF-9; GAF; HBFG-9; HBGF-9; SYN ...... |
Chromosomal Location | 13q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FGF9 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | FGF9 |
Name | fibroblast growth factor 9 |
Aliases | glia-activating factor; fibroblast growth factor 9 (glia-activating factor); FGF-9; GAF; HBFG-9; HBGF-9; SYN ...... |
Chromosomal Location | 13q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FGF9 collected from DrugBank database. |
There is no record. |