TISIDB

Summary
Symbol	FGFR1
Name	fibroblast growth factor receptor 1
Aliases	CEK; BFGFR; N-SAM; CD331; FLT2; KAL2; fms-related tyrosine kinase 2; FGFBR; FGFR-1; FLT-2; HBGFR; HH2; HRTFD ......
Chromosomal Location	8p11.23-p11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. Note=After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus.
Domain	PF07679 Immunoglobulin I-set domain PF00047 Immunoglobulin domain PF07714 Protein tyrosine kinase
Function	Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.

> Gene Ontology [ TOP ]
Biological Process	GO:0001501 skeletal system development GO:0001525 angiogenesis GO:0001655 urogenital system development GO:0001657 ureteric bud development GO:0001667 ameboidal-type cell migration GO:0001701 in utero embryonic development GO:0001704 formation of primary germ layer GO:0001707 mesoderm formation GO:0001708 cell fate specification GO:0001710 mesodermal cell fate commitment GO:0001759 organ induction GO:0001763 morphogenesis of a branching structure GO:0001764 neuron migration GO:0001818 negative regulation of cytokine production GO:0001822 kidney development GO:0001823 mesonephros development GO:0002053 positive regulation of mesenchymal cell proliferation GO:0002062 chondrocyte differentiation GO:0002064 epithelial cell development GO:0002065 columnar/cuboidal epithelial cell differentiation GO:0002066 columnar/cuboidal epithelial cell development GO:0003002 regionalization GO:0003156 regulation of animal organ formation GO:0006066 alcohol metabolic process GO:0006644 phospholipid metabolic process GO:0006650 glycerophospholipid metabolic process GO:0006661 phosphatidylinositol biosynthetic process GO:0006766 vitamin metabolic process GO:0006775 fat-soluble vitamin metabolic process GO:0006817 phosphate ion transport GO:0006820 anion transport GO:0007034 vacuolar transport GO:0007037 vacuolar phosphate transport GO:0007369 gastrulation GO:0007389 pattern specification process GO:0007405 neuroblast proliferation GO:0007423 sensory organ development GO:0007431 salivary gland development GO:0007435 salivary gland morphogenesis GO:0007498 mesoderm development GO:0007501 mesodermal cell fate specification GO:0007507 heart development GO:0007517 muscle organ development GO:0007605 sensory perception of sound GO:0008202 steroid metabolic process GO:0008543 fibroblast growth factor receptor signaling pathway GO:0008544 epidermis development GO:0008654 phospholipid biosynthetic process GO:0009913 epidermal cell differentiation GO:0009914 hormone transport GO:0010092 specification of animal organ identity GO:0010453 regulation of cell fate commitment GO:0010463 mesenchymal cell proliferation GO:0010464 regulation of mesenchymal cell proliferation GO:0010470 regulation of gastrulation GO:0010517 regulation of phospholipase activity GO:0010518 positive regulation of phospholipase activity GO:0010594 regulation of endothelial cell migration GO:0010595 positive regulation of endothelial cell migration GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010634 positive regulation of epithelial cell migration GO:0010720 positive regulation of cell development GO:0010817 regulation of hormone levels GO:0010863 positive regulation of phospholipase C activity GO:0010975 regulation of neuron projection development GO:0010976 positive regulation of neuron projection development GO:0014065 phosphatidylinositol 3-kinase signaling GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014706 striated muscle tissue development GO:0014855 striated muscle cell proliferation GO:0015698 inorganic anion transport GO:0016202 regulation of striated muscle tissue development GO:0017145 stem cell division GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0021700 developmental maturation GO:0021761 limbic system development GO:0021769 orbitofrontal cortex development GO:0021846 cell proliferation in forebrain GO:0021847 ventricular zone neuroblast division GO:0021869 forebrain ventricular zone progenitor cell division GO:0021872 forebrain generation of neurons GO:0021873 forebrain neuroblast division GO:0022612 gland morphogenesis GO:0023061 signal release GO:0030258 lipid modification GO:0030323 respiratory tube development GO:0030324 lung development GO:0030326 embryonic limb morphogenesis GO:0030335 positive regulation of cell migration GO:0030900 forebrain development GO:0030901 midbrain development GO:0031128 developmental induction GO:0031346 positive regulation of cell projection organization GO:0032103 positive regulation of response to external stimulus GO:0033002 muscle cell proliferation GO:0033674 positive regulation of kinase activity GO:0035107 appendage morphogenesis GO:0035108 limb morphogenesis GO:0035113 embryonic appendage morphogenesis GO:0035265 organ growth GO:0035272 exocrine system development GO:0035315 hair cell differentiation GO:0035607 fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development GO:0035766 cell chemotaxis to fibroblast growth factor GO:0035767 endothelial cell chemotaxis GO:0035768 endothelial cell chemotaxis to fibroblast growth factor GO:0035898 parathyroid hormone secretion GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process GO:0036445 neuronal stem cell division GO:0038034 signal transduction in absence of ligand GO:0040017 positive regulation of locomotion GO:0042359 vitamin D metabolic process GO:0042471 ear morphogenesis GO:0042472 inner ear morphogenesis GO:0042473 outer ear morphogenesis GO:0042474 middle ear morphogenesis GO:0042490 mechanoreceptor differentiation GO:0042491 auditory receptor cell differentiation GO:0042659 regulation of cell fate specification GO:0042661 regulation of mesodermal cell fate specification GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0043542 endothelial cell migration GO:0043583 ear development GO:0044057 regulation of system process GO:0044060 regulation of endocrine process GO:0044344 cellular response to fibroblast growth factor stimulus GO:0045017 glycerolipid biosynthetic process GO:0045165 cell fate commitment GO:0045666 positive regulation of neuron differentiation GO:0045787 positive regulation of cell cycle GO:0045844 positive regulation of striated muscle tissue development GO:0045860 positive regulation of protein kinase activity GO:0045927 positive regulation of growth GO:0045995 regulation of embryonic development GO:0046474 glycerophospholipid biosynthetic process GO:0046486 glycerolipid metabolic process GO:0046488 phosphatidylinositol metabolic process GO:0046620 regulation of organ growth GO:0046622 positive regulation of organ growth GO:0046777 protein autophosphorylation GO:0046834 lipid phosphorylation GO:0046854 phosphatidylinositol phosphorylation GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0046887 positive regulation of hormone secretion GO:0048015 phosphatidylinositol-mediated signaling GO:0048017 inositol lipid-mediated signaling GO:0048103 somatic stem cell division GO:0048332 mesoderm morphogenesis GO:0048333 mesodermal cell differentiation GO:0048339 paraxial mesoderm development GO:0048368 lateral mesoderm development GO:0048369 lateral mesoderm morphogenesis GO:0048370 lateral mesoderm formation GO:0048371 lateral mesodermal cell differentiation GO:0048372 lateral mesodermal cell fate commitment GO:0048377 lateral mesodermal cell fate specification GO:0048378 regulation of lateral mesodermal cell fate specification GO:0048469 cell maturation GO:0048514 blood vessel morphogenesis GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048634 regulation of muscle organ development GO:0048636 positive regulation of muscle organ development GO:0048638 regulation of developmental growth GO:0048639 positive regulation of developmental growth GO:0048645 animal organ formation GO:0048705 skeletal system morphogenesis GO:0048732 gland development GO:0048736 appendage development GO:0048738 cardiac muscle tissue development GO:0048762 mesenchymal cell differentiation GO:0048839 inner ear development GO:0050769 positive regulation of neurogenesis GO:0050886 endocrine process GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0050954 sensory perception of mechanical stimulus GO:0051047 positive regulation of secretion GO:0051216 cartilage development GO:0051272 positive regulation of cellular component movement GO:0051962 positive regulation of nervous system development GO:0055017 cardiac muscle tissue growth GO:0055021 regulation of cardiac muscle tissue growth GO:0055023 positive regulation of cardiac muscle tissue growth GO:0055024 regulation of cardiac muscle tissue development GO:0055025 positive regulation of cardiac muscle tissue development GO:0055057 neuroblast division GO:0060038 cardiac muscle cell proliferation GO:0060043 regulation of cardiac muscle cell proliferation GO:0060045 positive regulation of cardiac muscle cell proliferation GO:0060113 inner ear receptor cell differentiation GO:0060117 auditory receptor cell development GO:0060119 inner ear receptor cell development GO:0060173 limb development GO:0060191 regulation of lipase activity GO:0060193 positive regulation of lipase activity GO:0060326 cell chemotaxis GO:0060419 heart growth GO:0060420 regulation of heart growth GO:0060421 positive regulation of heart growth GO:0060445 branching involved in salivary gland morphogenesis GO:0060484 lung-associated mesenchyme development GO:0060485 mesenchyme development GO:0060537 muscle tissue development GO:0060541 respiratory system development GO:0060563 neuroepithelial cell differentiation GO:0060638 mesenchymal-epithelial cell signaling GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling GO:0060688 regulation of morphogenesis of a branching structure GO:0060693 regulation of branching involved in salivary gland morphogenesis GO:0060795 cell fate commitment involved in formation of primary germ layer GO:0060986 endocrine hormone secretion GO:0061138 morphogenesis of a branching epithelium GO:0061351 neural precursor cell proliferation GO:0061448 connective tissue development GO:0070640 vitamin D3 metabolic process GO:0071774 response to fibroblast growth factor GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0072001 renal system development GO:0072073 kidney epithelium development GO:0072089 stem cell proliferation GO:0072132 mesenchyme morphogenesis GO:0072163 mesonephric epithelium development GO:0072164 mesonephric tubule development GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090130 tissue migration GO:0090132 epithelium migration GO:0090269 fibroblast growth factor production GO:0090270 regulation of fibroblast growth factor production GO:0090272 negative regulation of fibroblast growth factor production GO:0090287 regulation of cellular response to growth factor stimulus GO:0090596 sensory organ morphogenesis GO:0097191 extrinsic apoptotic signaling pathway GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand GO:1900274 regulation of phospholipase C activity GO:1901615 organic hydroxy compound metabolic process GO:1901861 regulation of muscle tissue development GO:1901863 positive regulation of muscle tissue development GO:1902652 secondary alcohol metabolic process GO:1903532 positive regulation of secretion by cell GO:1904847 regulation of cell chemotaxis to fibroblast growth factor GO:1904849 positive regulation of cell chemotaxis to fibroblast growth factor GO:1905330 regulation of morphogenesis of an epithelium GO:2000027 regulation of organ morphogenesis GO:2000147 positive regulation of cell motility GO:2000380 regulation of mesoderm development GO:2000544 regulation of endothelial cell chemotaxis to fibroblast growth factor GO:2000546 positive regulation of endothelial cell chemotaxis to fibroblast growth factor GO:2000828 regulation of parathyroid hormone secretion GO:2000830 positive regulation of parathyroid hormone secretion GO:2001026 regulation of endothelial cell chemotaxis GO:2001028 positive regulation of endothelial cell chemotaxis GO:2001233 regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand
Molecular Function	GO:0004713 protein tyrosine kinase activity GO:0004714 transmembrane receptor protein tyrosine kinase activity GO:0005007 fibroblast growth factor-activated receptor activity GO:0005085 guanyl-nucleotide exchange factor activity GO:0005088 Ras guanyl-nucleotide exchange factor activity GO:0005539 glycosaminoglycan binding GO:0008201 heparin binding GO:0016303 1-phosphatidylinositol-3-kinase activity GO:0017134 fibroblast growth factor binding GO:0019199 transmembrane receptor protein kinase activity GO:0019838 growth factor binding GO:0035004 phosphatidylinositol 3-kinase activity GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0052742 phosphatidylinositol kinase activity GO:0052813 phosphatidylinositol bisphosphate kinase activity GO:1901681 sulfur compound binding
Cellular Component	GO:0043235 receptor complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04010 MAPK signaling pathway hsa04014 Ras signaling pathway hsa04015 Rap1 signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04520 Adherens junction hsa04550 Signaling pathways regulating pluripotency of stem cells hsa04810 Regulation of actin cytoskeleton
Reactome	R-HSA-170984: ARMS-mediated activation R-HSA-1280218: Adaptive Immune System R-HSA-422475: Axon guidance R-HSA-2219530: Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-186763: Downstream signal transduction R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR) R-HSA-5654687: Downstream signaling of activated FGFR1 R-HSA-2871796: FCERI mediated MAPK activation R-HSA-190242: FGFR1 ligand binding and activation R-HSA-1839124: FGFR1 mutant receptor activation R-HSA-190370: FGFR1b ligand binding and activation R-HSA-190374: FGFR1c and Klotho ligand binding and activation R-HSA-190373: FGFR1c ligand binding and activation R-HSA-5654693: FRS-mediated FGFR1 signaling R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-170968: Frs2-mediated activation R-HSA-180292: GAB1 signalosome R-HSA-179812: GRB2 events in EGFR signaling R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-2428924: IGF1R signaling cascade R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-74751: Insulin receptor signalling cascade R-HSA-912526: Interleukin receptor SHC signaling R-HSA-451927: Interleukin-2 signaling R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling R-HSA-373760: L1CAM interactions R-HSA-5683057: MAPK family signaling cascades R-HSA-5684996: MAPK1/MAPK3 signaling R-HSA-375165: NCAM signaling for neurite out-growth R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-5654726: Negative regulation of FGFR1 signaling R-HSA-199418: Negative regulation of the PI3K/AKT network R-HSA-5654689: PI-3K cascade R-HSA-109704: PI3K Cascade R-HSA-2219528: PI3K/AKT Signaling in Cancer R-HSA-198203: PI3K/AKT activation R-HSA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-1257604: PIP3 activates AKT signaling R-HSA-5654219: Phospholipase C-mediated cascade R-HSA-169893: Prolonged ERK activation events R-HSA-5673001: RAF/MAP kinase cascade R-HSA-8853659: RET signaling R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-5654688: SHC-mediated cascade R-HSA-180336: SHC1 events in EGFR signaling R-HSA-112412: SOS-mediated signalling R-HSA-162582: Signal Transduction R-HSA-445144: Signal transduction by L1 R-HSA-177929: Signaling by EGFR R-HSA-190236: Signaling by FGFR R-HSA-1226099: Signaling by FGFR in disease R-HSA-5654736: Signaling by FGFR1 R-HSA-1839120: Signaling by FGFR1 amplification mutants R-HSA-5655302: Signaling by FGFR1 in disease R-HSA-372790: Signaling by GPCR R-HSA-74752: Signaling by Insulin receptor R-HSA-449147: Signaling by Interleukins R-HSA-2586552: Signaling by Leptin R-HSA-186797: Signaling by PDGF R-HSA-1433557: Signaling by SCF-KIT R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-194138: Signaling by VEGF R-HSA-1839122: Signaling by activated point mutants of FGFR1 R-HSA-8853336: Signaling by plasma membrane FGFR1 fusions R-HSA-983705: Signaling by the B Cell Receptor (BCR) R-HSA-166520: Signalling by NGF R-HSA-187687: Signalling to ERKs R-HSA-167044: Signalling to RAS R-HSA-187706: Signalling to p38 via RIT and RIN R-HSA-4420097: VEGFA-VEGFR2 Pathway R-HSA-5218921: VEGFR2 mediated cell proliferation

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04010 MAPK signaling pathway
hsa04014 Ras signaling pathway
hsa04015 Rap1 signaling pathway
hsa04151 PI3K-Akt signaling pathway
hsa04520 Adherens junction
hsa04550 Signaling pathways regulating pluripotency of stem cells
hsa04810 Regulation of actin cytoskeleton

Reactome

R-HSA-170984: ARMS-mediated activation
R-HSA-1280218: Adaptive Immune System
R-HSA-422475: Axon guidance
R-HSA-2219530: Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-2172127: DAP12 interactions
R-HSA-2424491: DAP12 signaling
R-HSA-1266738: Developmental Biology
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-186763: Downstream signal transduction
R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR)
R-HSA-5654687: Downstream signaling of activated FGFR1
R-HSA-2871796: FCERI mediated MAPK activation
R-HSA-190242: FGFR1 ligand binding and activation
R-HSA-1839124: FGFR1 mutant receptor activation
R-HSA-190370: FGFR1b ligand binding and activation
R-HSA-190374: FGFR1c and Klotho ligand binding and activation
R-HSA-190373: FGFR1c ligand binding and activation
R-HSA-5654693: FRS-mediated FGFR1 signaling
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-170968: Frs2-mediated activation
R-HSA-180292: GAB1 signalosome
R-HSA-179812: GRB2 events in EGFR signaling
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-2428924: IGF1R signaling cascade
R-HSA-112399: IRS-mediated signalling
R-HSA-2428928: IRS-related events triggered by IGF1R
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-74751: Insulin receptor signalling cascade
R-HSA-912526: Interleukin receptor SHC signaling
R-HSA-451927: Interleukin-2 signaling
R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling
R-HSA-373760: L1CAM interactions
R-HSA-5683057: MAPK family signaling cascades
R-HSA-5684996: MAPK1/MAPK3 signaling
R-HSA-375165: NCAM signaling for neurite out-growth
R-HSA-187037: NGF signalling via TRKA from the plasma membrane
R-HSA-5654726: Negative regulation of FGFR1 signaling
R-HSA-199418: Negative regulation of the PI3K/AKT network
R-HSA-5654689: PI-3K cascade
R-HSA-109704: PI3K Cascade
R-HSA-2219528: PI3K/AKT Signaling in Cancer
R-HSA-198203: PI3K/AKT activation
R-HSA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-1257604: PIP3 activates AKT signaling
R-HSA-5654219: Phospholipase C-mediated cascade
R-HSA-169893: Prolonged ERK activation events
R-HSA-5673001: RAF/MAP kinase cascade
R-HSA-8853659: RET signaling
R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-5654688: SHC-mediated cascade
R-HSA-180336: SHC1 events in EGFR signaling
R-HSA-112412: SOS-mediated signalling
R-HSA-162582: Signal Transduction
R-HSA-445144: Signal transduction by L1
R-HSA-177929: Signaling by EGFR
R-HSA-190236: Signaling by FGFR
R-HSA-1226099: Signaling by FGFR in disease
R-HSA-5654736: Signaling by FGFR1
R-HSA-1839120: Signaling by FGFR1 amplification mutants
R-HSA-5655302: Signaling by FGFR1 in disease
R-HSA-372790: Signaling by GPCR
R-HSA-74752: Signaling by Insulin receptor
R-HSA-449147: Signaling by Interleukins
R-HSA-2586552: Signaling by Leptin
R-HSA-186797: Signaling by PDGF
R-HSA-1433557: Signaling by SCF-KIT
R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-194138: Signaling by VEGF
R-HSA-1839122: Signaling by activated point mutants of FGFR1
R-HSA-8853336: Signaling by plasma membrane FGFR1 fusions
R-HSA-983705: Signaling by the B Cell Receptor (BCR)
R-HSA-166520: Signalling by NGF
R-HSA-187687: Signalling to ERKs
R-HSA-167044: Signalling to RAS
R-HSA-187706: Signalling to p38 via RIT and RIN
R-HSA-4420097: VEGFA-VEGFR2 Pathway
R-HSA-5218921: VEGFR2 mediated cell proliferation

Summary
Symbol	FGFR1
Name	fibroblast growth factor receptor 1
Aliases	CEK; BFGFR; N-SAM; CD331; FLT2; KAL2; fms-related tyrosine kinase 2; FGFBR; FGFR-1; FLT-2; HBGFR; HH2; HRTFD ......
Chromosomal Location	8p11.23-p11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between FGFR1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	FGFR1
Name	fibroblast growth factor receptor 1
Aliases	CEK; BFGFR; N-SAM; CD331; FLT2; KAL2; fms-related tyrosine kinase 2; FGFBR; FGFR-1; FLT-2; HBGFR; HH2; HRTFD ......
Chromosomal Location	8p11.23-p11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of FGFR1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	FGFR1
Name	fibroblast growth factor receptor 1
Aliases	CEK; BFGFR; N-SAM; CD331; FLT2; KAL2; fms-related tyrosine kinase 2; FGFBR; FGFR-1; FLT-2; HBGFR; HH2; HRTFD ......
Chromosomal Location	8p11.23-p11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of FGFR1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.953	0.0771
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.611	0.763
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-1.193	0.389
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.361	0.536
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.701	0.778
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.06	0.986
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.047	0.927
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.26	0.881
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.311	0.865
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.461	0.78
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.541	0.497
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.132	0.448

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of FGFR1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	11.1	0	11.1	0.0181
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	11.1	0	11.1	0.0286
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	9.5	0	9.5	0.492
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	12.5	0	12.5	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	0	7.7	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	6.2	-6.2	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	0	2.6	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	0	4.5	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	FGFR1
Name	fibroblast growth factor receptor 1
Aliases	CEK; BFGFR; N-SAM; CD331; FLT2; KAL2; fms-related tyrosine kinase 2; FGFBR; FGFR-1; FLT-2; HBGFR; HH2; HRTFD ......
Chromosomal Location	8p11.23-p11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FGFR1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	FGFR1
Name	fibroblast growth factor receptor 1
Aliases	CEK; BFGFR; N-SAM; CD331; FLT2; KAL2; fms-related tyrosine kinase 2; FGFBR; FGFR-1; FLT-2; HBGFR; HH2; HRTFD ......
Chromosomal Location	8p11.23-p11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FGFR1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FGFR1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	FGFR1
Name	fibroblast growth factor receptor 1
Aliases	CEK; BFGFR; N-SAM; CD331; FLT2; KAL2; fms-related tyrosine kinase 2; FGFBR; FGFR-1; FLT-2; HBGFR; HH2; HRTFD ......
Chromosomal Location	8p11.23-p11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FGFR1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	FGFR1
Name	fibroblast growth factor receptor 1
Aliases	CEK; BFGFR; N-SAM; CD331; FLT2; KAL2; fms-related tyrosine kinase 2; FGFBR; FGFR-1; FLT-2; HBGFR; HH2; HRTFD ......
Chromosomal Location	8p11.23-p11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of FGFR1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	FGFR1
Name	fibroblast growth factor receptor 1
Aliases	CEK; BFGFR; N-SAM; CD331; FLT2; KAL2; fms-related tyrosine kinase 2; FGFBR; FGFR-1; FLT-2; HBGFR; HH2; HRTFD ......
Chromosomal Location	8p11.23-p11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between FGFR1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	FGFR1
Name	fibroblast growth factor receptor 1
Aliases	CEK; BFGFR; N-SAM; CD331; FLT2; KAL2; fms-related tyrosine kinase 2; FGFBR; FGFR-1; FLT-2; HBGFR; HH2; HRTFD ......
Chromosomal Location	8p11.23-p11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting FGFR1 collected from DrugBank database.

> Drugs from DrugBank database

[ TOP ]

Details on drugs targeting FGFR1.

ID	Name	Drug Type	Targets	#Targets
DB00039	Palifermin	Biotech	FGFR1, FGFR2, FGFR3, FGFR4, HSPG2, NRP1	6
DB00398	Sorafenib	Small Molecule	BRAF, FGFR1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET	10
DB01109	Heparin	Small Molecule	F10, FGF1, FGF19, FGF2, FGF4, FGFR1, FGFR2, FGFR4, HGF, PF4, SELP, ......	12
DB02058	SU4984	Small Molecule	FGFR1, FGFR2	2
DB05014	XL999	Small Molecule	FGFR1, FGFR3, FLT3, KDR, PDGFRB	5
DB07525	3-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine	Small Molecule	FGFR1	1
DB07840	(E)-[4-(3,5-difluorophenyl)-3H-pyrrolo[2,3-b]pyridin-3-ylidene](3-methoxyphenyl)methanol	Small Molecule	FGFR1	1
DB08577	3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE	Small Molecule	FGFR1	1
DB08896	Regorafenib	Small Molecule	ABL1, BRAF, DDR2, EPHA2, FGFR1, FGFR2, FLT1, FLT4, FRK, KDR, KIT, ......	18
DB08901	Ponatinib	Small Molecule	ABL1, BCR, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, KDR, KIT, LCK, LYN, P ......	15
DB09078	Lenvatinib	Small Molecule	FGFR1, FGFR2, FGFR3, FGFR4, FLT1, FLT4, KDR, KIT	8
DB09079	Nintedanib	Small Molecule	FGFR1, FGFR2, FGFR3, FLT1, FLT3, FLT4, KDR, LCK, LYN, SRC	10

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