Browse FGFR2

Summary
SymbolFGFR2
Namefibroblast growth factor receptor 2
Aliases CEK3; TK14; TK25; ECT1; K-SAM; CD332; Crouzon syndrome; KGFR; BEK; JWS; bacteria-expressed kinase; keratinoc ......
Chromosomal Location10q25.3-q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane; Single-pass type I membrane protein. Golgi apparatus. Cytoplasmic vesicle. Note=Detected on osteoblast plasma membrane lipid rafts. After ligand binding, the activated receptor is rapidly internalized and degraded.; SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. Note=After ligand binding, the activated receptor is rapidly internalized and degraded.; SUBCELLULAR LOCATION: Isoform 3: Cell membrane; Single-pass type I membrane protein. Note=After ligand binding, the activated receptor is rapidly internalized and degraded.; SUBCELLULAR LOCATION: Isoform 14: Secreted.; SUBCELLULAR LOCATION: Isoform 19: Secreted.
Domain PF07679 Immunoglobulin I-set domain
PF07714 Protein tyrosine kinase
Function

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.

> Gene Ontology
 
Biological Process GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001525 angiogenesis
GO:0001649 osteoblast differentiation
GO:0001655 urogenital system development
GO:0001657 ureteric bud development
GO:0001701 in utero embryonic development
GO:0001704 formation of primary germ layer
GO:0001707 mesoderm formation
GO:0001763 morphogenesis of a branching structure
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0001837 epithelial to mesenchymal transition
GO:0001890 placenta development
GO:0001892 embryonic placenta development
GO:0001942 hair follicle development
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002065 columnar/cuboidal epithelial cell differentiation
GO:0002067 glandular epithelial cell differentiation
GO:0003002 regionalization
GO:0003007 heart morphogenesis
GO:0003148 outflow tract septum morphogenesis
GO:0003149 membranous septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003205 cardiac chamber development
GO:0003206 cardiac chamber morphogenesis
GO:0003208 cardiac ventricle morphogenesis
GO:0003229 ventricular cardiac muscle tissue development
GO:0003231 cardiac ventricle development
GO:0003279 cardiac septum development
GO:0003281 ventricular septum development
GO:0003401 axis elongation
GO:0006644 phospholipid metabolic process
GO:0006650 glycerophospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0007224 smoothened signaling pathway
GO:0007369 gastrulation
GO:0007389 pattern specification process
GO:0007405 neuroblast proliferation
GO:0007409 axonogenesis
GO:0007423 sensory organ development
GO:0007431 salivary gland development
GO:0007435 salivary gland morphogenesis
GO:0007498 mesoderm development
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008544 epidermis development
GO:0008589 regulation of smoothened signaling pathway
GO:0008654 phospholipid biosynthetic process
GO:0009791 post-embryonic development
GO:0009880 embryonic pattern specification
GO:0010092 specification of animal organ identity
GO:0010453 regulation of cell fate commitment
GO:0010463 mesenchymal cell proliferation
GO:0010464 regulation of mesenchymal cell proliferation
GO:0010517 regulation of phospholipase activity
GO:0010518 positive regulation of phospholipase activity
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0014706 striated muscle tissue development
GO:0014855 striated muscle cell proliferation
GO:0016055 Wnt signaling pathway
GO:0016202 regulation of striated muscle tissue development
GO:0016331 morphogenesis of embryonic epithelium
GO:0017145 stem cell division
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018212 peptidyl-tyrosine modification
GO:0021761 limbic system development
GO:0021769 orbitofrontal cortex development
GO:0021846 cell proliferation in forebrain
GO:0021847 ventricular zone neuroblast division
GO:0021859 pyramidal neuron differentiation
GO:0021860 pyramidal neuron development
GO:0021869 forebrain ventricular zone progenitor cell division
GO:0021872 forebrain generation of neurons
GO:0021873 forebrain neuroblast division
GO:0021879 forebrain neuron differentiation
GO:0021884 forebrain neuron development
GO:0021953 central nervous system neuron differentiation
GO:0021954 central nervous system neuron development
GO:0022404 molting cycle process
GO:0022405 hair cycle process
GO:0022612 gland morphogenesis
GO:0030111 regulation of Wnt signaling pathway
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030258 lipid modification
GO:0030278 regulation of ossification
GO:0030282 bone mineralization
GO:0030323 respiratory tube development
GO:0030324 lung development
GO:0030850 prostate gland development
GO:0030879 mammary gland development
GO:0030900 forebrain development
GO:0030901 midbrain development
GO:0030916 otic vesicle formation
GO:0031069 hair follicle morphogenesis
GO:0031214 biomineral tissue development
GO:0032808 lacrimal gland development
GO:0033002 muscle cell proliferation
GO:0033687 osteoblast proliferation
GO:0033688 regulation of osteoblast proliferation
GO:0035107 appendage morphogenesis
GO:0035108 limb morphogenesis
GO:0035239 tube morphogenesis
GO:0035264 multicellular organism growth
GO:0035265 organ growth
GO:0035272 exocrine system development
GO:0035602 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow
GO:0035603 fibroblast growth factor receptor signaling pathway involved in hemopoiesis
GO:0035604 fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow
GO:0035607 fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0036445 neuronal stem cell division
GO:0040014 regulation of multicellular organism growth
GO:0040036 regulation of fibroblast growth factor receptor signaling pathway
GO:0042303 molting cycle
GO:0042471 ear morphogenesis
GO:0042472 inner ear morphogenesis
GO:0042476 odontogenesis
GO:0042633 hair cycle
GO:0042692 muscle cell differentiation
GO:0043410 positive regulation of MAPK cascade
GO:0043583 ear development
GO:0043588 skin development
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0045017 glycerolipid biosynthetic process
GO:0045165 cell fate commitment
GO:0045667 regulation of osteoblast differentiation
GO:0045787 positive regulation of cell cycle
GO:0045844 positive regulation of striated muscle tissue development
GO:0045927 positive regulation of growth
GO:0046474 glycerophospholipid biosynthetic process
GO:0046486 glycerolipid metabolic process
GO:0046488 phosphatidylinositol metabolic process
GO:0046620 regulation of organ growth
GO:0046622 positive regulation of organ growth
GO:0046777 protein autophosphorylation
GO:0046834 lipid phosphorylation
GO:0046854 phosphatidylinositol phosphorylation
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048017 inositol lipid-mediated signaling
GO:0048103 somatic stem cell division
GO:0048286 lung alveolus development
GO:0048332 mesoderm morphogenesis
GO:0048333 mesodermal cell differentiation
GO:0048514 blood vessel morphogenesis
GO:0048546 digestive tract morphogenesis
GO:0048557 embryonic digestive tract morphogenesis
GO:0048562 embryonic organ morphogenesis
GO:0048565 digestive tract development
GO:0048566 embryonic digestive tract development
GO:0048568 embryonic organ development
GO:0048608 reproductive structure development
GO:0048634 regulation of muscle organ development
GO:0048636 positive regulation of muscle organ development
GO:0048638 regulation of developmental growth
GO:0048639 positive regulation of developmental growth
GO:0048644 muscle organ morphogenesis
GO:0048645 animal organ formation
GO:0048659 smooth muscle cell proliferation
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
GO:0048730 epidermis morphogenesis
GO:0048732 gland development
GO:0048736 appendage development
GO:0048738 cardiac muscle tissue development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048755 branching morphogenesis of a nerve
GO:0048762 mesenchymal cell differentiation
GO:0048839 inner ear development
GO:0048863 stem cell differentiation
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051145 smooth muscle cell differentiation
GO:0051147 regulation of muscle cell differentiation
GO:0051150 regulation of smooth muscle cell differentiation
GO:0051302 regulation of cell division
GO:0051781 positive regulation of cell division
GO:0055008 cardiac muscle tissue morphogenesis
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0055017 cardiac muscle tissue growth
GO:0055021 regulation of cardiac muscle tissue growth
GO:0055023 positive regulation of cardiac muscle tissue growth
GO:0055024 regulation of cardiac muscle tissue development
GO:0055025 positive regulation of cardiac muscle tissue development
GO:0055057 neuroblast division
GO:0055123 digestive system development
GO:0060038 cardiac muscle cell proliferation
GO:0060043 regulation of cardiac muscle cell proliferation
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060070 canonical Wnt signaling pathway
GO:0060173 limb development
GO:0060174 limb bud formation
GO:0060191 regulation of lipase activity
GO:0060193 positive regulation of lipase activity
GO:0060348 bone development
GO:0060349 bone morphogenesis
GO:0060411 cardiac septum morphogenesis
GO:0060412 ventricular septum morphogenesis
GO:0060415 muscle tissue morphogenesis
GO:0060419 heart growth
GO:0060420 regulation of heart growth
GO:0060421 positive regulation of heart growth
GO:0060425 lung morphogenesis
GO:0060428 lung epithelium development
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060442 branching involved in prostate gland morphogenesis
GO:0060443 mammary gland morphogenesis
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060449 bud elongation involved in lung branching
GO:0060462 lung lobe development
GO:0060463 lung lobe morphogenesis
GO:0060484 lung-associated mesenchyme development
GO:0060485 mesenchyme development
GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0060502 epithelial cell proliferation involved in lung morphogenesis
GO:0060512 prostate gland morphogenesis
GO:0060523 prostate epithelial cord elongation
GO:0060525 prostate glandular acinus development
GO:0060526 prostate glandular acinus morphogenesis
GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060529 squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0060537 muscle tissue development
GO:0060541 respiratory system development
GO:0060560 developmental growth involved in morphogenesis
GO:0060562 epithelial tube morphogenesis
GO:0060571 morphogenesis of an epithelial fold
GO:0060572 morphogenesis of an epithelial bud
GO:0060592 mammary gland formation
GO:0060594 mammary gland specification
GO:0060595 fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:0060601 lateral sprouting from an epithelium
GO:0060602 branch elongation of an epithelium
GO:0060603 mammary gland duct morphogenesis
GO:0060615 mammary gland bud formation
GO:0060648 mammary gland bud morphogenesis
GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060667 branch elongation involved in salivary gland morphogenesis
GO:0060669 embryonic placenta morphogenesis
GO:0060670 branching involved in labyrinthine layer morphogenesis
GO:0060687 regulation of branching involved in prostate gland morphogenesis
GO:0060688 regulation of morphogenesis of a branching structure
GO:0060711 labyrinthine layer development
GO:0060713 labyrinthine layer morphogenesis
GO:0060736 prostate gland growth
GO:0060737 prostate gland morphogenetic growth
GO:0060740 prostate gland epithelium morphogenesis
GO:0060742 epithelial cell differentiation involved in prostate gland development
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0060915 mesenchymal cell differentiation involved in lung development
GO:0060916 mesenchymal cell proliferation involved in lung development
GO:0061138 morphogenesis of a branching epithelium
GO:0061180 mammary gland epithelium development
GO:0061351 neural precursor cell proliferation
GO:0061458 reproductive system development
GO:0061564 axon development
GO:0070371 ERK1 and ERK2 cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071599 otic vesicle development
GO:0071600 otic vesicle morphogenesis
GO:0071774 response to fibroblast growth factor
GO:0071863 regulation of cell proliferation in bone marrow
GO:0071864 positive regulation of cell proliferation in bone marrow
GO:0071865 regulation of apoptotic process in bone marrow
GO:0071866 negative regulation of apoptotic process in bone marrow
GO:0072001 renal system development
GO:0072073 kidney epithelium development
GO:0072089 stem cell proliferation
GO:0072163 mesonephric epithelium development
GO:0072164 mesonephric tubule development
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0090287 regulation of cellular response to growth factor stimulus
GO:0090596 sensory organ morphogenesis
GO:0098773 skin epidermis development
GO:0198738 cell-cell signaling by wnt
GO:1901861 regulation of muscle tissue development
GO:1901863 positive regulation of muscle tissue development
GO:1904888 cranial skeletal system development
GO:1905330 regulation of morphogenesis of an epithelium
GO:2000027 regulation of organ morphogenesis
GO:2000241 regulation of reproductive process
GO:2000794 regulation of epithelial cell proliferation involved in lung morphogenesis
Molecular Function GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005007 fibroblast growth factor-activated receptor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005539 glycosaminoglycan binding
GO:0008201 heparin binding
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0017134 fibroblast growth factor binding
GO:0019199 transmembrane receptor protein kinase activity
GO:0019838 growth factor binding
GO:0035004 phosphatidylinositol 3-kinase activity
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0052742 phosphatidylinositol kinase activity
GO:0052813 phosphatidylinositol bisphosphate kinase activity
GO:1901681 sulfur compound binding
Cellular Component GO:0005938 cell cortex
GO:0060076 excitatory synapse
GO:0099568 cytoplasmic region
> KEGG and Reactome Pathway
 
KEGG hsa04010 MAPK signaling pathway
hsa04014 Ras signaling pathway
hsa04015 Rap1 signaling pathway
hsa04144 Endocytosis
hsa04151 PI3K-Akt signaling pathway
hsa04550 Signaling pathways regulating pluripotency of stem cells
hsa04810 Regulation of actin cytoskeleton
Reactome R-HSA-170984: ARMS-mediated activation
R-HSA-2033519: Activated point mutants of FGFR2
R-HSA-1280218: Adaptive Immune System
R-HSA-422475: Axon guidance
R-HSA-2219530: Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-2172127: DAP12 interactions
R-HSA-2424491: DAP12 signaling
R-HSA-1266738: Developmental Biology
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-186763: Downstream signal transduction
R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR)
R-HSA-5654696: Downstream signaling of activated FGFR2
R-HSA-2871796: FCERI mediated MAPK activation
R-HSA-190241: FGFR2 ligand binding and activation
R-HSA-1839126: FGFR2 mutant receptor activation
R-HSA-190377: FGFR2b ligand binding and activation
R-HSA-190375: FGFR2c ligand binding and activation
R-HSA-5654700: FRS-mediated FGFR2 signaling
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-170968: Frs2-mediated activation
R-HSA-180292: GAB1 signalosome
R-HSA-179812: GRB2 events in EGFR signaling
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-2428924: IGF1R signaling cascade
R-HSA-112399: IRS-mediated signalling
R-HSA-2428928: IRS-related events triggered by IGF1R
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-74751: Insulin receptor signalling cascade
R-HSA-912526: Interleukin receptor SHC signaling
R-HSA-451927: Interleukin-2 signaling
R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling
R-HSA-5683057: MAPK family signaling cascades
R-HSA-5684996: MAPK1/MAPK3 signaling
R-HSA-375165: NCAM signaling for neurite out-growth
R-HSA-187037: NGF signalling via TRKA from the plasma membrane
R-HSA-5654727: Negative regulation of FGFR2 signaling
R-HSA-199418: Negative regulation of the PI3K/AKT network
R-HSA-5654695: PI-3K cascade
R-HSA-109704: PI3K Cascade
R-HSA-2219528: PI3K/AKT Signaling in Cancer
R-HSA-198203: PI3K/AKT activation
R-HSA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-1257604: PIP3 activates AKT signaling
R-HSA-5654221: Phospholipase C-mediated cascade; FGFR2
R-HSA-169893: Prolonged ERK activation events
R-HSA-5673001: RAF/MAP kinase cascade
R-HSA-8853659: RET signaling
R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-5654699: SHC-mediated cascade
R-HSA-180336: SHC1 events in EGFR signaling
R-HSA-112412: SOS-mediated signalling
R-HSA-162582: Signal Transduction
R-HSA-177929: Signaling by EGFR
R-HSA-190236: Signaling by FGFR
R-HSA-1226099: Signaling by FGFR in disease
R-HSA-5654738: Signaling by FGFR2
R-HSA-8851708: Signaling by FGFR2 IIIa TM
R-HSA-2023837: Signaling by FGFR2 amplification mutants
R-HSA-8853333: Signaling by FGFR2 fusions
R-HSA-5655253: Signaling by FGFR2 in disease
R-HSA-372790: Signaling by GPCR
R-HSA-74752: Signaling by Insulin receptor
R-HSA-449147: Signaling by Interleukins
R-HSA-2586552: Signaling by Leptin
R-HSA-186797: Signaling by PDGF
R-HSA-1433557: Signaling by SCF-KIT
R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-194138: Signaling by VEGF
R-HSA-983705: Signaling by the B Cell Receptor (BCR)
R-HSA-166520: Signalling by NGF
R-HSA-187687: Signalling to ERKs
R-HSA-167044: Signalling to RAS
R-HSA-187706: Signalling to p38 via RIT and RIN
R-HSA-4420097: VEGFA-VEGFR2 Pathway
R-HSA-5218921: VEGFR2 mediated cell proliferation
Summary
SymbolFGFR2
Namefibroblast growth factor receptor 2
Aliases CEK3; TK14; TK25; ECT1; K-SAM; CD332; Crouzon syndrome; KGFR; BEK; JWS; bacteria-expressed kinase; keratinoc ......
Chromosomal Location10q25.3-q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between FGFR2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolFGFR2
Namefibroblast growth factor receptor 2
Aliases CEK3; TK14; TK25; ECT1; K-SAM; CD332; Crouzon syndrome; KGFR; BEK; JWS; bacteria-expressed kinase; keratinoc ......
Chromosomal Location10q25.3-q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of FGFR2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen Total # shRNA with >= 4-fold: 1 Resistant to T-cell proliferation
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolFGFR2
Namefibroblast growth factor receptor 2
Aliases CEK3; TK14; TK25; ECT1; K-SAM; CD332; Crouzon syndrome; KGFR; BEK; JWS; bacteria-expressed kinase; keratinoc ......
Chromosomal Location10q25.3-q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of FGFR2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0730.888
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.6120.467
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.5790.415
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.7220.163
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 591.2240.565
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0860.974
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0240.978
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15112.0620.0898
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-2.3550.0725
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0380.976
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.1230.944
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1110.546
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of FGFR2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.41.460.177
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.41.75.70.231
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.85.9-1.11
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.79.1-1.41
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382715.83.712.10.224
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221318.27.710.50.63
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161412.5012.50.485
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolFGFR2
Namefibroblast growth factor receptor 2
Aliases CEK3; TK14; TK25; ECT1; K-SAM; CD332; Crouzon syndrome; KGFR; BEK; JWS; bacteria-expressed kinase; keratinoc ......
Chromosomal Location10q25.3-q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FGFR2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolFGFR2
Namefibroblast growth factor receptor 2
Aliases CEK3; TK14; TK25; ECT1; K-SAM; CD332; Crouzon syndrome; KGFR; BEK; JWS; bacteria-expressed kinase; keratinoc ......
Chromosomal Location10q25.3-q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FGFR2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FGFR2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolFGFR2
Namefibroblast growth factor receptor 2
Aliases CEK3; TK14; TK25; ECT1; K-SAM; CD332; Crouzon syndrome; KGFR; BEK; JWS; bacteria-expressed kinase; keratinoc ......
Chromosomal Location10q25.3-q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FGFR2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolFGFR2
Namefibroblast growth factor receptor 2
Aliases CEK3; TK14; TK25; ECT1; K-SAM; CD332; Crouzon syndrome; KGFR; BEK; JWS; bacteria-expressed kinase; keratinoc ......
Chromosomal Location10q25.3-q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of FGFR2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolFGFR2
Namefibroblast growth factor receptor 2
Aliases CEK3; TK14; TK25; ECT1; K-SAM; CD332; Crouzon syndrome; KGFR; BEK; JWS; bacteria-expressed kinase; keratinoc ......
Chromosomal Location10q25.3-q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between FGFR2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolFGFR2
Namefibroblast growth factor receptor 2
Aliases CEK3; TK14; TK25; ECT1; K-SAM; CD332; Crouzon syndrome; KGFR; BEK; JWS; bacteria-expressed kinase; keratinoc ......
Chromosomal Location10q25.3-q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting FGFR2 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting FGFR2.
ID Name Drug Type Targets #Targets
DB00039PaliferminBiotechFGFR1, FGFR2, FGFR3, FGFR4, HSPG2, NRP16
DB01041ThalidomideSmall MoleculeCRBN, FGFR2, NFKB1, ORM1, ORM2, PTGS2, TNF7
DB01109HeparinSmall MoleculeF10, FGF1, FGF19, FGF2, FGF4, FGFR1, FGFR2, FGFR4, HGF, PF4, SELP, ......12
DB01901SucrosofateSmall MoleculeFGF1, FGFR22
DB02058SU4984Small MoleculeFGFR1, FGFR22
DB024914-[4-(1-Amino-1-Methylethyl)Phenyl]-5-Chloro-N-[4-(2-Morpholin-4-Ylethyl)Phenyl]Pyrimidin-2-AmineSmall MoleculeFGFR21
DB08896RegorafenibSmall MoleculeABL1, BRAF, DDR2, EPHA2, FGFR1, FGFR2, FLT1, FLT4, FRK, KDR, KIT, ......18
DB08901PonatinibSmall MoleculeABL1, BCR, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, KDR, KIT, LCK, LYN, P ......15
DB09078LenvatinibSmall MoleculeFGFR1, FGFR2, FGFR3, FGFR4, FLT1, FLT4, KDR, KIT8
DB09079NintedanibSmall MoleculeFGFR1, FGFR2, FGFR3, FLT1, FLT3, FLT4, KDR, LCK, LYN, SRC10