TISIDB

Summary
Symbol	FIP1L1
Name	factor interacting with PAPOLA and CPSF1
Aliases	DKFZp586K0717; FIP1 like 1 (S. cerevisiae); FIP1L1 cleavage and polyadenylation specific factor subunit; hFi ......
Chromosomal Location	4q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Nucleus.
Domain	PF05182 Fip1 motif
Function	Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex.

> Gene Ontology [ TOP ]
Biological Process	GO:0000375 RNA splicing, via transesterification reactions GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile GO:0000398 mRNA splicing, via spliceosome GO:0006353 DNA-templated transcription, termination GO:0006369 termination of RNA polymerase II transcription GO:0006397 mRNA processing GO:0006403 RNA localization GO:0006405 RNA export from nucleus GO:0006406 mRNA export from nucleus GO:0006913 nucleocytoplasmic transport GO:0008380 RNA splicing GO:0015931 nucleobase-containing compound transport GO:0031123 RNA 3'-end processing GO:0031124 mRNA 3'-end processing GO:0050657 nucleic acid transport GO:0050658 RNA transport GO:0051028 mRNA transport GO:0051168 nuclear export GO:0051169 nuclear transport GO:0051236 establishment of RNA localization GO:0071166 ribonucleoprotein complex localization GO:0071426 ribonucleoprotein complex export from nucleus GO:0071427 mRNA-containing ribonucleoprotein complex export from nucleus
Molecular Function	-
Cellular Component	GO:0005847 mRNA cleavage and polyadenylation specificity factor complex GO:0005849 mRNA cleavage factor complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa03015 mRNA surveillance pathway
Reactome	R-HSA-109688: Cleavage of Growing Transcript in the Termination Region R-HSA-74160: Gene Expression R-HSA-112296: Post-Elongation Processing of Intron-Containing pre-mRNA R-HSA-112297: Post-Elongation Processing of Intronless pre-mRNA R-HSA-76044: Post-Elongation Processing of the Transcript R-HSA-72203: Processing of Capped Intron-Containing Pre-mRNA R-HSA-75067: Processing of Capped Intronless Pre-mRNA R-HSA-77595: Processing of Intronless Pre-mRNAs R-HSA-73857: RNA Polymerase II Transcription R-HSA-73856: RNA Polymerase II Transcription Termination R-HSA-72202: Transport of Mature Transcript to Cytoplasm R-HSA-159231: Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159234: Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-72187: mRNA 3'-end processing R-HSA-72172: mRNA Splicing R-HSA-72163: mRNA Splicing - Major Pathway

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa03015 mRNA surveillance pathway

Reactome

R-HSA-109688: Cleavage of Growing Transcript in the Termination Region
R-HSA-74160: Gene Expression
R-HSA-112296: Post-Elongation Processing of Intron-Containing pre-mRNA
R-HSA-112297: Post-Elongation Processing of Intronless pre-mRNA
R-HSA-76044: Post-Elongation Processing of the Transcript
R-HSA-72203: Processing of Capped Intron-Containing Pre-mRNA
R-HSA-75067: Processing of Capped Intronless Pre-mRNA
R-HSA-77595: Processing of Intronless Pre-mRNAs
R-HSA-73857: RNA Polymerase II Transcription
R-HSA-73856: RNA Polymerase II Transcription Termination
R-HSA-72202: Transport of Mature Transcript to Cytoplasm
R-HSA-159231: Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159234: Transport of Mature mRNAs Derived from Intronless Transcripts
R-HSA-72187: mRNA 3'-end processing
R-HSA-72172: mRNA Splicing
R-HSA-72163: mRNA Splicing - Major Pathway

Summary
Symbol	FIP1L1
Name	factor interacting with PAPOLA and CPSF1
Aliases	DKFZp586K0717; FIP1 like 1 (S. cerevisiae); FIP1L1 cleavage and polyadenylation specific factor subunit; hFi ......
Chromosomal Location	4q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between FIP1L1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	FIP1L1
Name	factor interacting with PAPOLA and CPSF1
Aliases	DKFZp586K0717; FIP1 like 1 (S. cerevisiae); FIP1L1 cleavage and polyadenylation specific factor subunit; hFi ......
Chromosomal Location	4q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of FIP1L1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	Second most enriched score: 0.6	Sensitive to T cell-mediated killing
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	FIP1L1
Name	factor interacting with PAPOLA and CPSF1
Aliases	DKFZp586K0717; FIP1 like 1 (S. cerevisiae); FIP1L1 cleavage and polyadenylation specific factor subunit; hFi ......
Chromosomal Location	4q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of FIP1L1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.163	0.433
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.015	0.994
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.295	0.838
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.089	0.707
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.168	0.936
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.012	0.996
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.142	0.634
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.101	0.939
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.181	0.9
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.439	0.755
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.964	0.645
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.075	0.144

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of FIP1L1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	7.1	0	7.1	0.452
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	10	0	10	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	0	0	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	0	0	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	0	4.8	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	0	7.7	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	22.2	12.5	9.7	0.602
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	40	11.1	28.9	0.505
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	14.3	-14.3	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	FIP1L1
Name	factor interacting with PAPOLA and CPSF1
Aliases	DKFZp586K0717; FIP1 like 1 (S. cerevisiae); FIP1L1 cleavage and polyadenylation specific factor subunit; hFi ......
Chromosomal Location	4q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FIP1L1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	FIP1L1
Name	factor interacting with PAPOLA and CPSF1
Aliases	DKFZp586K0717; FIP1 like 1 (S. cerevisiae); FIP1L1 cleavage and polyadenylation specific factor subunit; hFi ......
Chromosomal Location	4q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FIP1L1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FIP1L1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	FIP1L1
Name	factor interacting with PAPOLA and CPSF1
Aliases	DKFZp586K0717; FIP1 like 1 (S. cerevisiae); FIP1L1 cleavage and polyadenylation specific factor subunit; hFi ......
Chromosomal Location	4q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FIP1L1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	FIP1L1
Name	factor interacting with PAPOLA and CPSF1
Aliases	DKFZp586K0717; FIP1 like 1 (S. cerevisiae); FIP1L1 cleavage and polyadenylation specific factor subunit; hFi ......
Chromosomal Location	4q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of FIP1L1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	FIP1L1
Name	factor interacting with PAPOLA and CPSF1
Aliases	DKFZp586K0717; FIP1 like 1 (S. cerevisiae); FIP1L1 cleavage and polyadenylation specific factor subunit; hFi ......
Chromosomal Location	4q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between FIP1L1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	FIP1L1
Name	factor interacting with PAPOLA and CPSF1
Aliases	DKFZp586K0717; FIP1 like 1 (S. cerevisiae); FIP1L1 cleavage and polyadenylation specific factor subunit; hFi ......
Chromosomal Location	4q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting FIP1L1 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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