Browse FIS1

Summary
SymbolFIS1
Namefission, mitochondrial 1
Aliases CGI-135; H_NH0132A01.6; CGI-135 protein; mitochondrial fission molecule; TTC11; tetratricopeptide repeat dom ......
Chromosomal Location7q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein.
Domain PF14853 Fis1 C-terminal tetratricopeptide repeat
PF14852 Fis1 N-terminal tetratricopeptide repeat
Function

Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.

> Gene Ontology
 
Biological Process GO:0000266 mitochondrial fission
GO:0000422 mitophagy
GO:0001836 release of cytochrome c from mitochondria
GO:0006612 protein targeting to membrane
GO:0006626 protein targeting to mitochondrion
GO:0006839 mitochondrial transport
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0006914 autophagy
GO:0007031 peroxisome organization
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008053 mitochondrial fusion
GO:0008637 apoptotic mitochondrial changes
GO:0010821 regulation of mitochondrion organization
GO:0010822 positive regulation of mitochondrion organization
GO:0010950 positive regulation of endopeptidase activity
GO:0010952 positive regulation of peptidase activity
GO:0016559 peroxisome fission
GO:0019722 calcium-mediated signaling
GO:0019932 second-messenger-mediated signaling
GO:0032386 regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration
GO:0033157 regulation of intracellular protein transport
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043653 mitochondrial fragmentation involved in apoptotic process
GO:0044801 single-organism membrane fusion
GO:0045862 positive regulation of proteolysis
GO:0048284 organelle fusion
GO:0051222 positive regulation of protein transport
GO:0051259 protein oligomerization
GO:0051260 protein homooligomerization
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051560 mitochondrial calcium ion homeostasis
GO:0051561 positive regulation of mitochondrial calcium ion concentration
GO:0052547 regulation of peptidase activity
GO:0052548 regulation of endopeptidase activity
GO:0055074 calcium ion homeostasis
GO:0061025 membrane fusion
GO:0061726 mitochondrion disassembly
GO:0070584 mitochondrion morphogenesis
GO:0070585 protein localization to mitochondrion
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072655 establishment of protein localization to mitochondrion
GO:0072657 protein localization to membrane
GO:0090140 regulation of mitochondrial fission
GO:0090141 positive regulation of mitochondrial fission
GO:0090150 establishment of protein localization to membrane
GO:0090313 regulation of protein targeting to membrane
GO:0090314 positive regulation of protein targeting to membrane
GO:0090316 positive regulation of intracellular protein transport
GO:0097193 intrinsic apoptotic signaling pathway
GO:1903008 organelle disassembly
GO:1903533 regulation of protein targeting
GO:1903829 positive regulation of cellular protein localization
GO:1904951 positive regulation of establishment of protein localization
GO:2000116 regulation of cysteine-type endopeptidase activity
GO:2001056 positive regulation of cysteine-type endopeptidase activity
GO:2001233 regulation of apoptotic signaling pathway
GO:2001235 positive regulation of apoptotic signaling pathway
GO:2001242 regulation of intrinsic apoptotic signaling pathway
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Molecular Function -
Cellular Component GO:0005741 mitochondrial outer membrane
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005779 integral component of peroxisomal membrane
GO:0019867 outer membrane
GO:0031231 intrinsic component of peroxisomal membrane
GO:0031300 intrinsic component of organelle membrane
GO:0031301 integral component of organelle membrane
GO:0031306 intrinsic component of mitochondrial outer membrane
GO:0031307 integral component of mitochondrial outer membrane
GO:0031903 microbody membrane
GO:0031968 organelle outer membrane
GO:0032592 integral component of mitochondrial membrane
GO:0042579 microbody
GO:0044438 microbody part
GO:0044439 peroxisomal part
GO:0044455 mitochondrial membrane part
GO:0098573 intrinsic component of mitochondrial membrane
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolFIS1
Namefission, mitochondrial 1
Aliases CGI-135; H_NH0132A01.6; CGI-135 protein; mitochondrial fission molecule; TTC11; tetratricopeptide repeat dom ......
Chromosomal Location7q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between FIS1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolFIS1
Namefission, mitochondrial 1
Aliases CGI-135; H_NH0132A01.6; CGI-135 protein; mitochondrial fission molecule; TTC11; tetratricopeptide repeat dom ......
Chromosomal Location7q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of FIS1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -2.98; FDR: 0.03680 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolFIS1
Namefission, mitochondrial 1
Aliases CGI-135; H_NH0132A01.6; CGI-135 protein; mitochondrial fission molecule; TTC11; tetratricopeptide repeat dom ......
Chromosomal Location7q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of FIS1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0590.862
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.2750.938
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0960.971
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2270.508
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.2770.882
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1660.945
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.20.618
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.4670.789
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0410.984
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.2260.926
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.5340.89
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0680.271
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolFIS1
Namefission, mitochondrial 1
Aliases CGI-135; H_NH0132A01.6; CGI-135 protein; mitochondrial fission molecule; TTC11; tetratricopeptide repeat dom ......
Chromosomal Location7q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FIS1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolFIS1
Namefission, mitochondrial 1
Aliases CGI-135; H_NH0132A01.6; CGI-135 protein; mitochondrial fission molecule; TTC11; tetratricopeptide repeat dom ......
Chromosomal Location7q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FIS1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FIS1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolFIS1
Namefission, mitochondrial 1
Aliases CGI-135; H_NH0132A01.6; CGI-135 protein; mitochondrial fission molecule; TTC11; tetratricopeptide repeat dom ......
Chromosomal Location7q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FIS1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolFIS1
Namefission, mitochondrial 1
Aliases CGI-135; H_NH0132A01.6; CGI-135 protein; mitochondrial fission molecule; TTC11; tetratricopeptide repeat dom ......
Chromosomal Location7q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of FIS1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolFIS1
Namefission, mitochondrial 1
Aliases CGI-135; H_NH0132A01.6; CGI-135 protein; mitochondrial fission molecule; TTC11; tetratricopeptide repeat dom ......
Chromosomal Location7q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between FIS1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolFIS1
Namefission, mitochondrial 1
Aliases CGI-135; H_NH0132A01.6; CGI-135 protein; mitochondrial fission molecule; TTC11; tetratricopeptide repeat dom ......
Chromosomal Location7q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting FIS1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.