Browse FNDC4

Summary
SymbolFNDC4
Namefibronectin type III domain containing 4
Aliases FLJ22362; FRCP1; fibronectin type III repeat-containing protein 1; Fibronectin type III domain-containing pr ......
Chromosomal Location2p23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane Single-pass type I membrane protein Secreted Note=The N-terminus is probably cleaved to release a secreted extracellular portion of the protein.
Domain PF00041 Fibronectin type III domain
Function

Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro-inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis.

> Gene Ontology
 
Biological Process -
Molecular Function -
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolFNDC4
Namefibronectin type III domain containing 4
Aliases FLJ22362; FRCP1; fibronectin type III repeat-containing protein 1; Fibronectin type III domain-containing pr ......
Chromosomal Location2p23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between FNDC4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolFNDC4
Namefibronectin type III domain containing 4
Aliases FLJ22362; FRCP1; fibronectin type III repeat-containing protein 1; Fibronectin type III domain-containing pr ......
Chromosomal Location2p23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of FNDC4 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolFNDC4
Namefibronectin type III domain containing 4
Aliases FLJ22362; FRCP1; fibronectin type III repeat-containing protein 1; Fibronectin type III domain-containing pr ......
Chromosomal Location2p23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of FNDC4 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.6310.217
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.4230.325
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0330.97
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0680.89
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.5960.566
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.6110.677
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3080.577
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.2360.796
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.3490.729
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.6370.627
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6630.716
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2260.176
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of FNDC4 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolFNDC4
Namefibronectin type III domain containing 4
Aliases FLJ22362; FRCP1; fibronectin type III repeat-containing protein 1; Fibronectin type III domain-containing pr ......
Chromosomal Location2p23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FNDC4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolFNDC4
Namefibronectin type III domain containing 4
Aliases FLJ22362; FRCP1; fibronectin type III repeat-containing protein 1; Fibronectin type III domain-containing pr ......
Chromosomal Location2p23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FNDC4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FNDC4.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolFNDC4
Namefibronectin type III domain containing 4
Aliases FLJ22362; FRCP1; fibronectin type III repeat-containing protein 1; Fibronectin type III domain-containing pr ......
Chromosomal Location2p23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FNDC4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolFNDC4
Namefibronectin type III domain containing 4
Aliases FLJ22362; FRCP1; fibronectin type III repeat-containing protein 1; Fibronectin type III domain-containing pr ......
Chromosomal Location2p23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of FNDC4 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolFNDC4
Namefibronectin type III domain containing 4
Aliases FLJ22362; FRCP1; fibronectin type III repeat-containing protein 1; Fibronectin type III domain-containing pr ......
Chromosomal Location2p23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between FNDC4 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolFNDC4
Namefibronectin type III domain containing 4
Aliases FLJ22362; FRCP1; fibronectin type III repeat-containing protein 1; Fibronectin type III domain-containing pr ......
Chromosomal Location2p23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting FNDC4 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.