Browse FOXP1

Summary
SymbolFOXP1
Nameforkhead box P1
Aliases QRF1; 12CC4; HSPC215; hFKH1B; fork head-related protein like B; glutamine-rich factor 1; PAX5/FOXP1 fusion p ......
Chromosomal Location3p14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Note=Not found in the nucleolus.
Domain PF00250 Forkhead domain
PF16159 FOXP coiled-coil domain
Function

Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18799727, PubMed:18347093). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). ; FUNCTION: Isoform 8: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity).

> Gene Ontology
 
Biological Process GO:0001501 skeletal system development
GO:0001667 ameboidal-type cell migration
GO:0001783 B cell apoptotic process
GO:0002237 response to molecule of bacterial origin
GO:0002263 cell activation involved in immune response
GO:0002274 myeloid leukocyte activation
GO:0002285 lymphocyte activation involved in immune response
GO:0002286 T cell activation involved in immune response
GO:0002287 alpha-beta T cell activation involved in immune response
GO:0002292 T cell differentiation involved in immune response
GO:0002293 alpha-beta T cell differentiation involved in immune response
GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response
GO:0002366 leukocyte activation involved in immune response
GO:0002521 leukocyte differentiation
GO:0002573 myeloid leukocyte differentiation
GO:0002761 regulation of myeloid leukocyte differentiation
GO:0002831 regulation of response to biotic stimulus
GO:0002902 regulation of B cell apoptotic process
GO:0002903 negative regulation of B cell apoptotic process
GO:0003158 endothelium development
GO:0003159 morphogenesis of an endothelium
GO:0007159 leukocyte cell-cell adhesion
GO:0009306 protein secretion
GO:0009755 hormone-mediated signaling pathway
GO:0010594 regulation of endothelial cell migration
GO:0010595 positive regulation of endothelial cell migration
GO:0010631 epithelial cell migration
GO:0010632 regulation of epithelial cell migration
GO:0010634 positive regulation of epithelial cell migration
GO:0030098 lymphocyte differentiation
GO:0030099 myeloid cell differentiation
GO:0030217 T cell differentiation
GO:0030224 monocyte differentiation
GO:0030316 osteoclast differentiation
GO:0030335 positive regulation of cell migration
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030521 androgen receptor signaling pathway
GO:0030522 intracellular receptor signaling pathway
GO:0032496 response to lipopolysaccharide
GO:0032602 chemokine production
GO:0032611 interleukin-1 beta production
GO:0032612 interleukin-1 production
GO:0032615 interleukin-12 production
GO:0032625 interleukin-21 production
GO:0032640 tumor necrosis factor production
GO:0032651 regulation of interleukin-1 beta production
GO:0032652 regulation of interleukin-1 production
GO:0032655 regulation of interleukin-12 production
GO:0032680 regulation of tumor necrosis factor production
GO:0033002 muscle cell proliferation
GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway
GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway
GO:0035239 tube morphogenesis
GO:0035710 CD4-positive, alpha-beta T cell activation
GO:0035926 chemokine (C-C motif) ligand 2 secretion
GO:0036035 osteoclast development
GO:0036301 macrophage colony-stimulating factor production
GO:0040017 positive regulation of locomotion
GO:0042093 T-helper cell differentiation
GO:0042110 T cell activation
GO:0042116 macrophage activation
GO:0042117 monocyte activation
GO:0042118 endothelial cell activation
GO:0042742 defense response to bacterium
GO:0043367 CD4-positive, alpha-beta T cell differentiation
GO:0043401 steroid hormone mediated signaling pathway
GO:0043542 endothelial cell migration
GO:0043900 regulation of multi-organism process
GO:0045637 regulation of myeloid cell differentiation
GO:0045655 regulation of monocyte differentiation
GO:0046631 alpha-beta T cell activation
GO:0046632 alpha-beta T cell differentiation
GO:0048545 response to steroid hormone
GO:0048659 smooth muscle cell proliferation
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050663 cytokine secretion
GO:0050701 interleukin-1 secretion
GO:0050702 interleukin-1 beta secretion
GO:0050704 regulation of interleukin-1 secretion
GO:0050706 regulation of interleukin-1 beta secretion
GO:0050707 regulation of cytokine secretion
GO:0050708 regulation of protein secretion
GO:0050727 regulation of inflammatory response
GO:0051272 positive regulation of cellular component movement
GO:0060348 bone development
GO:0060562 epithelial tube morphogenesis
GO:0060765 regulation of androgen receptor signaling pathway
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0061154 endothelial tube morphogenesis
GO:0061470 T follicular helper cell differentiation
GO:0061515 myeloid cell development
GO:0070227 lymphocyte apoptotic process
GO:0070228 regulation of lymphocyte apoptotic process
GO:0070229 negative regulation of lymphocyte apoptotic process
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0071383 cellular response to steroid hormone stimulus
GO:0071396 cellular response to lipid
GO:0071407 cellular response to organic cyclic compound
GO:0071593 lymphocyte aggregation
GO:0071706 tumor necrosis factor superfamily cytokine production
GO:0071887 leukocyte apoptotic process
GO:0072567 chemokine (C-X-C motif) ligand 2 production
GO:0072610 interleukin-12 secretion
GO:0072619 interleukin-21 secretion
GO:0090130 tissue migration
GO:0090132 epithelium migration
GO:0090195 chemokine secretion
GO:0098542 defense response to other organism
GO:0098751 bone cell development
GO:1900424 regulation of defense response to bacterium
GO:1901256 regulation of macrophage colony-stimulating factor production
GO:1901509 regulation of endothelial tube morphogenesis
GO:1902105 regulation of leukocyte differentiation
GO:1903131 mononuclear cell differentiation
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production
GO:1903706 regulation of hemopoiesis
GO:1905330 regulation of morphogenesis of an epithelium
GO:2000106 regulation of leukocyte apoptotic process
GO:2000107 negative regulation of leukocyte apoptotic process
GO:2000147 positive regulation of cell motility
GO:2001182 regulation of interleukin-12 secretion
Molecular Function GO:0035257 nuclear hormone receptor binding
GO:0035258 steroid hormone receptor binding
GO:0043621 protein self-association
GO:0050681 androgen receptor binding
GO:0051427 hormone receptor binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1266738: Developmental Biology
R-HSA-452723: Transcriptional regulation of pluripotent stem cells
Summary
SymbolFOXP1
Nameforkhead box P1
Aliases QRF1; 12CC4; HSPC215; hFKH1B; fork head-related protein like B; glutamine-rich factor 1; PAX5/FOXP1 fusion p ......
Chromosomal Location3p14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between FOXP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between FOXP1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
26500140Diffuse Large B-Cell LymphomaInhibit immunityFOXP1 knockdown in ABC-DLBCL cells led to increased cell-surface expression of HLA-DRA and CD74. We propose that FOXP1 represents a novel regulator of genes targeted by the class II MHC transactivator CIITA (MHC II and CD74) and therapeutically targeting the FOXP1 pathway may improve antigen presentation and immune surveillance in high-risk DLBCL patients.
25238097ovarian carcinomaInhibit immunity (T cell function)Here we have characterized a common mechanism of T cell unresponsiveness in cancer driven by the upregulation of the transcription factor Forkhead box protein P1 (Foxp1), which prevents CD8(+) T cells from proliferating and upregulating Granzyme-B and interferon-gamma in response to tumor antigens.
Summary
SymbolFOXP1
Nameforkhead box P1
Aliases QRF1; 12CC4; HSPC215; hFKH1B; fork head-related protein like B; glutamine-rich factor 1; PAX5/FOXP1 fusion p ......
Chromosomal Location3p14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of FOXP1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolFOXP1
Nameforkhead box P1
Aliases QRF1; 12CC4; HSPC215; hFKH1B; fork head-related protein like B; glutamine-rich factor 1; PAX5/FOXP1 fusion p ......
Chromosomal Location3p14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of FOXP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.3060.441
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.230.863
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.6920.458
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2340.461
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0860.975
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.4260.901
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3820.416
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.7250.589
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0150.992
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.4050.714
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.140.444
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2160.015
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of FOXP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.75.5-1.81
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.75.1-1.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.63.7-1.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolFOXP1
Nameforkhead box P1
Aliases QRF1; 12CC4; HSPC215; hFKH1B; fork head-related protein like B; glutamine-rich factor 1; PAX5/FOXP1 fusion p ......
Chromosomal Location3p14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FOXP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolFOXP1
Nameforkhead box P1
Aliases QRF1; 12CC4; HSPC215; hFKH1B; fork head-related protein like B; glutamine-rich factor 1; PAX5/FOXP1 fusion p ......
Chromosomal Location3p14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FOXP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FOXP1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolFOXP1
Nameforkhead box P1
Aliases QRF1; 12CC4; HSPC215; hFKH1B; fork head-related protein like B; glutamine-rich factor 1; PAX5/FOXP1 fusion p ......
Chromosomal Location3p14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FOXP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolFOXP1
Nameforkhead box P1
Aliases QRF1; 12CC4; HSPC215; hFKH1B; fork head-related protein like B; glutamine-rich factor 1; PAX5/FOXP1 fusion p ......
Chromosomal Location3p14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of FOXP1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolFOXP1
Nameforkhead box P1
Aliases QRF1; 12CC4; HSPC215; hFKH1B; fork head-related protein like B; glutamine-rich factor 1; PAX5/FOXP1 fusion p ......
Chromosomal Location3p14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between FOXP1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolFOXP1
Nameforkhead box P1
Aliases QRF1; 12CC4; HSPC215; hFKH1B; fork head-related protein like B; glutamine-rich factor 1; PAX5/FOXP1 fusion p ......
Chromosomal Location3p14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting FOXP1 collected from DrugBank database.
> Drugs from DrugBank database
 

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