Browse FSCN1

Summary
SymbolFSCN1
Namefascin actin-bundling protein 1
Aliases FLJ38511; Singed, drosophila, homolog-like; actin bundling protein; SNL; singed (Drosophila)-like (sea urchi ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm, cytosol Cytoplasm, cytoskeleton Cell projection, filopodium Cell projection, invadopodium Cell projection, microvillus Cell junction Note=In glioma cells, partially colocalizes with F-actin stress fibers in the cytosol (PubMed:21706053). Colocalized with RUFY3 and F-actin at filipodia of the axonal growth cone. Colocalized with DBN1 and F-actin at the transitional domain of the axonal growth cone (By similarity).
Domain PF06268 Fascin domain
Function

Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.

> Gene Ontology
 
Biological Process GO:0007015 actin filament organization
GO:0007043 cell-cell junction assembly
GO:0007163 establishment or maintenance of cell polarity
GO:0010591 regulation of lamellipodium assembly
GO:0010592 positive regulation of lamellipodium assembly
GO:0010715 regulation of extracellular matrix disassembly
GO:0022617 extracellular matrix disassembly
GO:0030010 establishment of cell polarity
GO:0030031 cell projection assembly
GO:0030032 lamellipodium assembly
GO:0030033 microvillus assembly
GO:0030035 microspike assembly
GO:0030198 extracellular matrix organization
GO:0031334 positive regulation of protein complex assembly
GO:0031346 positive regulation of cell projection organization
GO:0032528 microvillus organization
GO:0032530 regulation of microvillus organization
GO:0032534 regulation of microvillus assembly
GO:0032956 regulation of actin cytoskeleton organization
GO:0032970 regulation of actin filament-based process
GO:0034329 cell junction assembly
GO:0034330 cell junction organization
GO:0035088 establishment or maintenance of apical/basal cell polarity
GO:0035089 establishment of apical/basal cell polarity
GO:0043062 extracellular structure organization
GO:0043254 regulation of protein complex assembly
GO:0044089 positive regulation of cellular component biogenesis
GO:0045216 cell-cell junction organization
GO:0046847 filopodium assembly
GO:0051017 actin filament bundle assembly
GO:0051489 regulation of filopodium assembly
GO:0051491 positive regulation of filopodium assembly
GO:0051493 regulation of cytoskeleton organization
GO:0060491 regulation of cell projection assembly
GO:0061162 establishment of monopolar cell polarity
GO:0061245 establishment or maintenance of bipolar cell polarity
GO:0061339 establishment or maintenance of monopolar cell polarity
GO:0061572 actin filament bundle organization
GO:0071800 podosome assembly
GO:0071801 regulation of podosome assembly
GO:0071803 positive regulation of podosome assembly
GO:0090091 positive regulation of extracellular matrix disassembly
GO:0097581 lamellipodium organization
GO:1902115 regulation of organelle assembly
GO:1902117 positive regulation of organelle assembly
GO:1902743 regulation of lamellipodium organization
GO:1902745 positive regulation of lamellipodium organization
GO:1903053 regulation of extracellular matrix organization
GO:1903055 positive regulation of extracellular matrix organization
Molecular Function GO:0003779 actin binding
GO:0008144 drug binding
GO:0030674 protein binding, bridging
GO:0045296 cadherin binding
GO:0050839 cell adhesion molecule binding
GO:0051015 actin filament binding
GO:0060090 binding, bridging
GO:0098631 protein binding involved in cell adhesion
GO:0098632 protein binding involved in cell-cell adhesion
GO:0098641 cadherin binding involved in cell-cell adhesion
Cellular Component GO:0001725 stress fiber
GO:0001726 ruffle
GO:0002102 podosome
GO:0005884 actin filament
GO:0005902 microvillus
GO:0005913 cell-cell adherens junction
GO:0015629 actin cytoskeleton
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0030426 growth cone
GO:0030427 site of polarized growth
GO:0031252 cell leading edge
GO:0031253 cell projection membrane
GO:0031941 filamentous actin
GO:0032432 actin filament bundle
GO:0042641 actomyosin
GO:0043209 myelin sheath
GO:0044393 microspike
GO:0071437 invadopodium
GO:0097517 contractile actin filament bundle
GO:0098858 actin-based cell projection
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-168256: Immune System
R-HSA-6785807: Interleukin-4 and 13 signaling
R-HSA-449147: Signaling by Interleukins
Summary
SymbolFSCN1
Namefascin actin-bundling protein 1
Aliases FLJ38511; Singed, drosophila, homolog-like; actin bundling protein; SNL; singed (Drosophila)-like (sea urchi ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between FSCN1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolFSCN1
Namefascin actin-bundling protein 1
Aliases FLJ38511; Singed, drosophila, homolog-like; actin bundling protein; SNL; singed (Drosophila)-like (sea urchi ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of FSCN1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolFSCN1
Namefascin actin-bundling protein 1
Aliases FLJ38511; Singed, drosophila, homolog-like; actin bundling protein; SNL; singed (Drosophila)-like (sea urchi ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of FSCN1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.6770.0206
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-2.0070.503
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-1.4420.535
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1440.779
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0510.982
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.260.927
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0040.993
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.4680.797
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.6130.749
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2660.883
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.1980.638
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.310.064
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of FSCN1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolFSCN1
Namefascin actin-bundling protein 1
Aliases FLJ38511; Singed, drosophila, homolog-like; actin bundling protein; SNL; singed (Drosophila)-like (sea urchi ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FSCN1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolFSCN1
Namefascin actin-bundling protein 1
Aliases FLJ38511; Singed, drosophila, homolog-like; actin bundling protein; SNL; singed (Drosophila)-like (sea urchi ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FSCN1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FSCN1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolFSCN1
Namefascin actin-bundling protein 1
Aliases FLJ38511; Singed, drosophila, homolog-like; actin bundling protein; SNL; singed (Drosophila)-like (sea urchi ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FSCN1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolFSCN1
Namefascin actin-bundling protein 1
Aliases FLJ38511; Singed, drosophila, homolog-like; actin bundling protein; SNL; singed (Drosophila)-like (sea urchi ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of FSCN1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolFSCN1
Namefascin actin-bundling protein 1
Aliases FLJ38511; Singed, drosophila, homolog-like; actin bundling protein; SNL; singed (Drosophila)-like (sea urchi ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between FSCN1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolFSCN1
Namefascin actin-bundling protein 1
Aliases FLJ38511; Singed, drosophila, homolog-like; actin bundling protein; SNL; singed (Drosophila)-like (sea urchi ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting FSCN1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.