Browse FSHB

Summary
SymbolFSHB
Namefollicle stimulating hormone, beta polypeptide
Aliases follitropin, beta chain; follicle-stimulating hormone beta subunit; HH24; FSH-B; FSH-beta; follitropin beta ......
Chromosomal Location11p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted.
Domain PF00007 Cystine-knot domain
Function

Stimulates development of follicle and spermatogenesis in the reproductive organs.

> Gene Ontology
 
Biological Process GO:0001541 ovarian follicle development
GO:0001894 tissue homeostasis
GO:0002521 leukocyte differentiation
GO:0002573 myeloid leukocyte differentiation
GO:0002761 regulation of myeloid leukocyte differentiation
GO:0006694 steroid biosynthetic process
GO:0006700 C21-steroid hormone biosynthetic process
GO:0006701 progesterone biosynthetic process
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007292 female gamete generation
GO:0007548 sex differentiation
GO:0007565 female pregnancy
GO:0008202 steroid metabolic process
GO:0008207 C21-steroid hormone metabolic process
GO:0008406 gonad development
GO:0008584 male gonad development
GO:0008585 female gonad development
GO:0010817 regulation of hormone levels
GO:0016485 protein processing
GO:0016486 peptide hormone processing
GO:0022602 ovulation cycle process
GO:0030099 myeloid cell differentiation
GO:0030316 osteoclast differentiation
GO:0030335 positive regulation of cell migration
GO:0032844 regulation of homeostatic process
GO:0032846 positive regulation of homeostatic process
GO:0034103 regulation of tissue remodeling
GO:0034105 positive regulation of tissue remodeling
GO:0034754 cellular hormone metabolic process
GO:0040017 positive regulation of locomotion
GO:0042180 cellular ketone metabolic process
GO:0042181 ketone biosynthetic process
GO:0042445 hormone metabolic process
GO:0042446 hormone biosynthetic process
GO:0042448 progesterone metabolic process
GO:0042698 ovulation cycle
GO:0042699 follicle-stimulating hormone signaling pathway
GO:0044283 small molecule biosynthetic process
GO:0044706 multi-multicellular organism process
GO:0045124 regulation of bone resorption
GO:0045137 development of primary sexual characteristics
GO:0045453 bone resorption
GO:0045637 regulation of myeloid cell differentiation
GO:0045670 regulation of osteoclast differentiation
GO:0045780 positive regulation of bone resorption
GO:0046545 development of primary female sexual characteristics
GO:0046546 development of primary male sexual characteristics
GO:0046660 female sex differentiation
GO:0046661 male sex differentiation
GO:0046849 bone remodeling
GO:0046850 regulation of bone remodeling
GO:0046852 positive regulation of bone remodeling
GO:0048511 rhythmic process
GO:0048608 reproductive structure development
GO:0048771 tissue remodeling
GO:0048871 multicellular organismal homeostasis
GO:0050673 epithelial cell proliferation
GO:0051272 positive regulation of cellular component movement
GO:0051604 protein maturation
GO:0060011 Sertoli cell proliferation
GO:0060249 anatomical structure homeostasis
GO:0061458 reproductive system development
GO:0071559 response to transforming growth factor beta
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:1902105 regulation of leukocyte differentiation
GO:1903706 regulation of hemopoiesis
GO:2000147 positive regulation of cell motility
Molecular Function GO:0005179 hormone activity
GO:0016913 follicle-stimulating hormone activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04024 cAMP signaling pathway
hsa04080 Neuroactive ligand-receptor interaction
hsa04912 GnRH signaling pathway
hsa04913 Ovarian steroidogenesis
Reactome R-HSA-373076: Class A/1 (Rhodopsin-like receptors)
R-HSA-418555: G alpha (s) signalling events
R-HSA-388396: GPCR downstream signaling
R-HSA-500792: GPCR ligand binding
R-HSA-209822: Glycoprotein hormones
R-HSA-375281: Hormone ligand-binding receptors
R-HSA-392499: Metabolism of proteins
R-HSA-209952: Peptide hormone biosynthesis
R-HSA-2980736: Peptide hormone metabolism
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
Summary
SymbolFSHB
Namefollicle stimulating hormone, beta polypeptide
Aliases follitropin, beta chain; follicle-stimulating hormone beta subunit; HH24; FSH-B; FSH-beta; follitropin beta ......
Chromosomal Location11p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between FSHB and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolFSHB
Namefollicle stimulating hormone, beta polypeptide
Aliases follitropin, beta chain; follicle-stimulating hormone beta subunit; HH24; FSH-B; FSH-beta; follitropin beta ......
Chromosomal Location11p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of FSHB in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.79 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolFSHB
Namefollicle stimulating hormone, beta polypeptide
Aliases follitropin, beta chain; follicle-stimulating hormone beta subunit; HH24; FSH-B; FSH-beta; follitropin beta ......
Chromosomal Location11p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of FSHB in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-1.9930.0233
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-2.460.143
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.3930.45
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 4801
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 2801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0470.522
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of FSHB in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.72.711
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.73.40.31
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382703.7-3.70.415
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolFSHB
Namefollicle stimulating hormone, beta polypeptide
Aliases follitropin, beta chain; follicle-stimulating hormone beta subunit; HH24; FSH-B; FSH-beta; follitropin beta ......
Chromosomal Location11p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FSHB. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolFSHB
Namefollicle stimulating hormone, beta polypeptide
Aliases follitropin, beta chain; follicle-stimulating hormone beta subunit; HH24; FSH-B; FSH-beta; follitropin beta ......
Chromosomal Location11p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FSHB. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FSHB.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolFSHB
Namefollicle stimulating hormone, beta polypeptide
Aliases follitropin, beta chain; follicle-stimulating hormone beta subunit; HH24; FSH-B; FSH-beta; follitropin beta ......
Chromosomal Location11p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FSHB. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolFSHB
Namefollicle stimulating hormone, beta polypeptide
Aliases follitropin, beta chain; follicle-stimulating hormone beta subunit; HH24; FSH-B; FSH-beta; follitropin beta ......
Chromosomal Location11p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of FSHB expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolFSHB
Namefollicle stimulating hormone, beta polypeptide
Aliases follitropin, beta chain; follicle-stimulating hormone beta subunit; HH24; FSH-B; FSH-beta; follitropin beta ......
Chromosomal Location11p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between FSHB and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolFSHB
Namefollicle stimulating hormone, beta polypeptide
Aliases follitropin, beta chain; follicle-stimulating hormone beta subunit; HH24; FSH-B; FSH-beta; follitropin beta ......
Chromosomal Location11p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting FSHB collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.