TISIDB

Summary
Symbol	FUT4
Name	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
Aliases	FUC-TIV; ELAM ligand fucosyltransferase; CD15; ELFT; FUTIV; LeX; SSEA-1; ELAM-1 ligand fucosyltransferase; L ......
Chromosomal Location	11q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
Domain	PF17039 Fucosyltransferase PF00852 Glycosyltransferase family 10 (fucosyltransferase) C-term
Function	May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.

> Gene Ontology [ TOP ]
Biological Process	GO:0005996 monosaccharide metabolic process GO:0006004 fucose metabolic process GO:0006486 protein glycosylation GO:0006487 protein N-linked glycosylation GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0016052 carbohydrate catabolic process GO:0019317 fucose catabolic process GO:0019318 hexose metabolic process GO:0019320 hexose catabolic process GO:0036065 fucosylation GO:0042354 L-fucose metabolic process GO:0042355 L-fucose catabolic process GO:0043413 macromolecule glycosylation GO:0044282 small molecule catabolic process GO:0044723 single-organism carbohydrate metabolic process GO:0044724 single-organism carbohydrate catabolic process GO:0046365 monosaccharide catabolic process GO:0070085 glycosylation
Molecular Function	GO:0008417 fucosyltransferase activity GO:0016757 transferase activity, transferring glycosyl groups GO:0016758 transferase activity, transferring hexosyl groups GO:0046920 alpha-(1->3)-fucosyltransferase activity
Cellular Component	GO:0005795 Golgi stack GO:0031984 organelle subcompartment GO:0031985 Golgi cisterna GO:0032580 Golgi cisterna membrane GO:0098791 Golgi subcompartment

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series hsa01100 Metabolic pathways
Reactome	-

Summary
Symbol	FUT4
Name	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
Aliases	FUC-TIV; ELAM ligand fucosyltransferase; CD15; ELFT; FUTIV; LeX; SSEA-1; ELAM-1 ligand fucosyltransferase; L ......
Chromosomal Location	11q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between FUT4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between FUT4 and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
25024303	lymphoma	Inhibit immunity (infiltration)	The serum absolute lymphocyte count, the presence of tumor-infiltrating dendritic cells, CD15 expression on the malignant cells, and tumor morphology were biomarkers of outcome in MGZL.
21480223	Bladder Carcinoma	Inhibit immunity	Our results demonstrate that PBMC from bladder cancer patients contain two major CD11b myeloid cell subsets: granulocyte-type CD15(high) CD33(low) cells and monocyte-type CD15(low) CD33(high) cells. Granulocytic myeloid cells were able to inhibit in vitro T cell proliferation through induction of CD4(+) Foxp3(+) T regulatory cells.

Summary
Symbol	FUT4
Name	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
Aliases	FUC-TIV; ELAM ligand fucosyltransferase; CD15; ELFT; FUTIV; LeX; SSEA-1; ELAM-1 ligand fucosyltransferase; L ......
Chromosomal Location	11q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of FUT4 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	FUT4
Name	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
Aliases	FUC-TIV; ELAM ligand fucosyltransferase; CD15; ELFT; FUTIV; LeX; SSEA-1; ELAM-1 ligand fucosyltransferase; L ......
Chromosomal Location	11q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of FUT4 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.806	0.00804
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.829	0.232
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.797	0.204
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.187	0.696
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.197	0.893
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.672	0.71
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.199	0.526
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.255	0.801
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.12	0.916
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.129	0.842
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.23	0.818
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.05	0.732

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of FUT4 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	0	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	0	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	6.2	-6.2	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	1

Summary
Symbol	FUT4
Name	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
Aliases	FUC-TIV; ELAM ligand fucosyltransferase; CD15; ELFT; FUTIV; LeX; SSEA-1; ELAM-1 ligand fucosyltransferase; L ......
Chromosomal Location	11q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FUT4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	FUT4
Name	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
Aliases	FUC-TIV; ELAM ligand fucosyltransferase; CD15; ELFT; FUTIV; LeX; SSEA-1; ELAM-1 ligand fucosyltransferase; L ......
Chromosomal Location	11q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FUT4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FUT4. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	FUT4
Name	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
Aliases	FUC-TIV; ELAM ligand fucosyltransferase; CD15; ELFT; FUTIV; LeX; SSEA-1; ELAM-1 ligand fucosyltransferase; L ......
Chromosomal Location	11q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FUT4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	FUT4
Name	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
Aliases	FUC-TIV; ELAM ligand fucosyltransferase; CD15; ELFT; FUTIV; LeX; SSEA-1; ELAM-1 ligand fucosyltransferase; L ......
Chromosomal Location	11q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of FUT4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	FUT4
Name	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
Aliases	FUC-TIV; ELAM ligand fucosyltransferase; CD15; ELFT; FUTIV; LeX; SSEA-1; ELAM-1 ligand fucosyltransferase; L ......
Chromosomal Location	11q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between FUT4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	FUT4
Name	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
Aliases	FUC-TIV; ELAM ligand fucosyltransferase; CD15; ELFT; FUTIV; LeX; SSEA-1; ELAM-1 ligand fucosyltransferase; L ......
Chromosomal Location	11q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting FUT4 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse FUT4